Tracheal Glomus Tumor: A Multidisciplinary Approach to Management

Sakr, Lama; Palaniappan, Ramanathan; Payan, Marie-José; Doddoli, Christophe; Dutau, Hervé

doi:10.4187/respcare.00761

Cited by 20 publications

(30 citation statements)

References 28 publications

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“…Endoscopic intervention alone is also applied in a limited number of cases, which has rigorous indications if: The lesion is strictly confined without extension; histology confirms the tumor is benign; as a temporary measure for surgery preparation; or the patient is not fit or willing to undergo surgical resection. In addition, interventional bronchoscopy is a first-line treatment to immediately restore the airway patency in urgent situations ( 14 , 16 , 17 , 25 – 27 , 30 ).…”

Section: Discussionmentioning

confidence: 99%

Glomangioma of the trachea: A case report and literature review

et al. 2015

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Abstract.A 44-year-old male presented with progressing cough, dyspnea and hemoptysis due to a tracheal tumor involving the posterior wall of the lower trachea, with severe airway obstruction and coagulopathy. Consequently the patient underwent segmental resection of the trachea with an end-to-end anastomosis. Twenty months after treatment there remained no evidence of endobronchial recurrence at bronchoscopy or imaging studies. The diagnosis was benign tracheal glomus tumor (GT) which is an exceedingly rare mass lesion in the trachea. There are three subtypes: GT proper, glomangioma and glomangiomyoma. The present study describes the clinical and pathological features of glomangioma through a case report and literature review. To the best of our knowledge, this is the fifth report of glomangioma subtype arising from the trachea. IntroductionGlomus tumors (GTs) are neoplasms arising from the modified smooth muscle cells surrounding arteriovenous anastomosis (1,2). GT is an uncommon soft tissue tumor with an incidence of 1.6%, which is usually located in the dermis and subcutaneous tissue, with ≤65% occurring in the subungual area. Due to sparse or absent glomus bodies in the visceral organs, extracutaneous presentation of GT is rarely observed (3-8). Previously reported atypical sites of origin include the stomach, mediastinum, vagina, penis, lung, patella and trachea. Histologically, GTs have been divided into three subtypes: Classic glomus tumors, glomangiomas, and glomangiomyomas. Glomangiomas are an uncommon type, accounting for <20% of GTs (1,2,9-11). Until now, only 27 cases of GTs, and five reports of glomangioma subtype arising from the trachea, including the present case, have been reported (8-32). GTs are usually benign and recurrence rates are variable, ranging from 10 to 30% (1,2). The present study reported a primary GT of the trachea, which is a possible differential diagnostic alternative when a tracheal tumor is detected by radiographic or endoscopic examination. Written informed consent was obtained from the patient and the patient's family. Case reportA 44-year-old male, exhibiting a defined tracheal tumor that was diagnosed by the local hospital (Bazhou People's Hospital, Bazhou, China) two months earlier, was admitted to our hospital (The Third People's Hospital of Chengdu, Chengdu, China) due to acute respiratory distress. The patient had suffered from cough, expectoration and dyspnea without any evident incentive for >1 year. Six days before admission, the symptoms were aggravated with hemoptysis. A chest X-ray scan was found to be normal. However, a computed tomographic (CT) scan revealed a demarcated homogenous intratracheal mass at the layer of the superior border of the manubrium (Fig. 1). Flexible bronchoscopy revealed a sessile tumor with a smooth surface arising from the posterior wall of the trachea, which occluded ~90% of the trachea lumen, at 3 cm proximal to the carina. A biopsy was performed to elucidate the nature of the tumor. At 3 h after referral, the patient exhibited no res...

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Section: Discussionmentioning

confidence: 99%

Glomangioma of the trachea: A case report and literature review

et al. 2015

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“…Multiple GTs are rare and account for approximately 10-25% of GT cases (13). Typical GTs are classified as solid GTs, glomangiomas and glomangiomyomas, depending on their dominant component (19). The classification…”

Section: Microscopic Featuresmentioning

confidence: 99%

Glomus tumors of the trachea: 2 case reports and a review of the literature

Wang

Zhao

et al. 2017

J. Thorac. Dis.

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Glomus tumors (GTs) of the trachea are very rare neoplasms that usually arise from the distal portion of the respiratory tree. The origin of these tumors is modified smooth muscle cells of glomus bodies. In this study, we describe two cases of GT of the trachea, as well as the histologic features of these tumors and their treatments. One tumor was diagnosed via bronchoscopic biopsy, and the other tumor was diagnosed via surgery. Clinical follow-up showed that the two patients are alive and well after 8 and 15 months post-treatment, respectively. We also review the literature regarding GTs and discuss the clinical presentation, histologic features, differential diagnosis, treatment and prognosis of these tumors.

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“…Furthermore, there is no epidemiological data due to the lack of large prospective or retrospective clinical studies. Through individual review of most up-to-date case reports and reviews of each individual tumor, we present the prevalence of each tumor as percentage of primary pulmonary tumors (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) or as number of reported cases as well as gender predominance, age predominance and associated risk factors, Table 2 (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28).…”

Section: Epidemiologymentioning

confidence: 99%

“…There are subtle differences in the diagnostic work-up for these tumors depending on the extent of the disease. General summary of the diagnostic tool and associated findings of each tumor is presented below ( Table 3) (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(30)(31)(32)(33)36,38,48,58,59) .…”

Section: Diagnostic Radiology and Bronchoscopymentioning

confidence: 99%

“…Endoscopic approach is preferred over surgical approach in patients with multiple co-morbidities and high surgical risk. Other treatment such as chemotherapy, radiotherapy and anti-inflammatory drugs may be used in conjunction with surgical or endoscopic management or as palliation for patient who have tumors that are candidates for endoscopic or surgical management (3,4,6,7,9,(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). A summary of most employed treatment modalities for rare airway tumors is provided in Table 4 (26,32,36,47,49,(58)(59)(60)(62)(63)(64)(65)(66)(67).…”

Section: Treatmentmentioning

confidence: 99%

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