Tardive dyskinesia syndromes: current concepts

Aquino, Camila C.; Lang, Anthony E.

doi:10.1016/s1353-8020(13)70028-2

Cited by 90 publications

(89 citation statements)

References 30 publications

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“…It has a short half-life and moreover, most of the adverse effects such as parkinsonism, depression, drowsiness related to TBZ are dose limiting. So TBZ may emerge as a safe drug for different phenotypes of TD in future [38] .…”

Section: Tardive Dyskinesiamentioning

confidence: 99%

Tetrabenazine: Spotlight on Drug Review

Kaur¹,

Kumar²,

Jamwal³

et al. 2016

Ann Neurosci

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Background: Tetrabenazine (TBZ) is the only US Food and Drug Administration-approved drug for the treatment of chorea related to Huntington's disease and other hyperkinetic disorders. TBZ was first synthesized in 1950, and was then used for the treatment of psychosis. But later its potential in treating hyperkinetic disorders was proved by its ability to block vesicular monoamine transporters 2 and deplete monoamine stores. There is still lack of awareness about the therapeutic potential of this drug. Summary: TBZ had been approved only for the treatment of chorea, but several clinical studies have been conducted by different research groups and it was concluded that TBZ is effective in various other conditions such as tardive dyskinesia, dystonia, tics, and Tourette's syndrome, thus, highlighting the need for further clinical trials in these conditions. Key Message: The intention of this review is to sum up the information regarding chemistry, mechanism of action, pharmacokinetics, interactions, contraindications, adverse effects, and clinical efficacy of TBZ in diseases other than Huntington's chorea.

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Section: Tardive Dyskinesiamentioning

confidence: 99%

Tetrabenazine: Spotlight on Drug Review

Kaur¹,

Kumar²,

Jamwal³

et al. 2016

Ann Neurosci

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show abstract

“…Hipertiroidi, hiperparatiroidi ve hiperglisemi seyrek olarak atetoid hareketlere sebep olabilirler. 16,22,23 Mekanizması tam olarak bilinmemektedir. Nigrositriatal dopamin reseptör sisteminde aşırı duyarlılık, dopaminerjik ve kolinerjik sistemler arasındaki dengenin bozulması, sitriatonigral GABA'erjik nöronlarda işlev bozukluğu ve eksitotoksisite üzerinde durulmaktadır.…”

Section: Geç Di̇ski̇nezi̇unclassified

Antipsychotic-Induced Tardive Syndromes: Clinical Features and Treatment Approaches

Uzun¹,

Aylak²

2017

Turkiye Klinikleri J Med Sci

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“…In jüngerer Zeit besteht die Tendenz, den Begriff "klassische TD" für orobuccolinguale Dyskinesien zu reservieren und eine spezifischere Terminologie, die auf der Phänomeno-logie der einzelnen Subtypen des tardiven Syndroms (TS) basiert, zu verwenden [6]. Dazu zählen TD, tar-dive Dystonie, tardiver Tremor, tardive Akathisie, tardiver Myoklonus sowie tardiver Tourettismus.…”

Section: Phänomenologieunclassified

“…So sind sich viele Patienten, insbesondere jene mit klassischer, buccolinguomastikatorischer (BLM) Trias, ihrer Symptome nicht bewusst. Die Bewegungsstörung kann über die Zeit fluktuierend und die Symptomatik kann durch die Medikation maskiert sein [6]. Die klassische TD ist die häufigste persistierende Nebenwirkung nach langem Antipsychotikagebrauch.…”

Section: Epidemiologieunclassified