(−)-Tarchonanthuslactone Exerts a Blood Glucose-Increasing Effect in Experimental Type 2 Diabetes Mellitus

Souza, Gabriela Freitas Pereira de; Novaes, Luiz F. T.; Avila, Carolina M.; Nascimento, Lucas F.; Velloso, Lı́cio A.; Pilli, Ronaldo Aloise

doi:10.3390/molecules20035038

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…Type 1 DM (T1DM) is a metabolic disease characterized by an insulin secretory defect due to the autoimmune destruction of the beta cells in the pancreas [ 4 ] and type 2 DM (T2DM) is a long term metabolic disorder characterized by high blood sugar (hyperglycemia), insulin resistance, and relative lack of insulin [ 5 ]. T2DM is the most common form and it accounts for 90–95% of all DM cases [ 6 , 7 , 8 ]. A national survey conducted in 2010 showed that the weighted prevalence of T2DM among Chinese adults aged 18 years and above was 9.7% [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic Effects of Tea

Liu

et al. 2017

Molecules

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Diabetes mellitus (DM) is a chronic endocrine disease resulted from insulin secretory defect or insulin resistance and it is a leading cause of death around the world. The care of DM patients consumes a huge budget due to the high frequency of consultations and long hospitalizations, making DM a serious threat to both human health and global economies. Tea contains abundant polyphenols and caffeine which showed antidiabetic activity, so the development of antidiabetic medications from tea and its extracts is increasingly receiving attention. However, the results claiming an association between tea consumption and reduced DM risk are inconsistent. The advances in the epidemiologic evidence and the underlying antidiabetic mechanisms of tea are reviewed in this paper. The inconsistent results and the possible causes behind them are also discussed.

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Section: Introductionmentioning

confidence: 99%

Antidiabetic Effects of Tea

Liu

et al. 2017

Molecules

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“…Hence, the product was confirmed as 3,4-di-tert-butyldimethylsiloxycinnamic (OTBS-caff) acid 198. Comparison with reported values in the literature 122 also confirmed its structure. With protected caffeic acids, the synthesis of 4CaI 201 and 4CaS 202 was attempted next.…”

Section: Scheme 28: Synthesis Of 34-di-tert-butyldimethylsiloxycinnamic Acid 198supporting

confidence: 86%

“…Analytical data for OTBS-caff acid 198: Comparison of 1 H NMR with reported values in literature 122 confirmed the formation of OTBS-caff acid 198.…”

Section: The Synthesis Of 34-di-tert-butyldimethylsiloxycinnamic Acid 198supporting

confidence: 66%

Development of phenylpropanoid sucrose esters as antidiabetic lead compounds

Ong¹

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coum' for coumaroyl, 'feru' for feruloyl, 'caff' for caffeoyl, 'diOMe' for dimethoxycinnamoyl, 'triOMe' for trimethoxycinnamoyl and 'sinap' for sinapoyl. For mixed PSEsThe naming of the mixed PSEs will follow the naming style of mono-substituted PSEs• The first field is a number representing the position at which the substituent is attached, for instance 3 for O-3, 3' for O-3', 4' for O-4' and 6' for O-6'• The second field represents the type of substituent groups, for instance 'cinn' for cinnamoyl 'coum' for coumaroyl, 'feru' for feruloyl, 'caff' for caffeoyl, 'diOMe' for dimethoxycinnamoyl, 'triOMe' for trimethoxycinnamoyl and 'sinap' for sinapoyl.

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(−)‐Tarchonanthuslactone: Design of New Analogues, Evaluation of their Antiproliferative Activity on Cancer Cell Lines, and Preliminary Mechanistic Studies

et al. 2015

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Natural products containing the α,β-unsaturated δ-lactone skeleton have been shown to possess a variety of biological activities. The natural product (-)-tarchonanthuslactone (1) possessing this privileged scaffold is a popular synthetic target, but its biological activity remains underexplored. Herein, the total syntheses of dihydropyran-2-ones modeled on the structure of 1 were undertaken. These compounds were obtained in overall yields of 17-21 % based on the Keck asymmetric allylation reaction and were evaluated in vitro against eight different cultured human tumor cell lines. We further conducted initial investigation into the mechanism of action of selected analogues. Dihydropyran-2-one 8 [(S,E)-(6-oxo-3,6-dihydro-2H-pyran-2-yl)methyl 3-(3,4-dihydroxyphenyl)acrylate], a simplified analogue of (-)-tarchonanthuslactone (1) bearing an additional electrophilic site and a catechol system, was the most cytotoxic and selective compound against six of the eight cancer cell lines analyzed, including the pancreatic cancer cell line. Preliminary studies on the mechanism of action of compound 8 on pancreatic cancer demonstrated that apoptotic cell death takes place mediated by an increase in the level of reactive oxygen species. It appears as though compound 8, possessing two Michael acceptors and a catechol system, may be a promising scaffold for the selective killing of cancer cells, and thus, it deserves further investigation to determine its potential for cancer therapy.

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(−)-Tarchonanthuslactone Exerts a Blood Glucose-Increasing Effect in Experimental Type 2 Diabetes Mellitus

Cited by 3 publications

References 29 publications

Antidiabetic Effects of Tea

Antidiabetic Effects of Tea

Development of phenylpropanoid sucrose esters as antidiabetic lead compounds

(−)‐Tarchonanthuslactone: Design of New Analogues, Evaluation of their Antiproliferative Activity on Cancer Cell Lines, and Preliminary Mechanistic Studies

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