Antidiabetic Effects of Tea

Fu, Qiu-Yue; Li, Qingsheng; Liu, Xiaoming; Qiao, Ru-Ying; Yang, Rui; Li, Xu-Min; Dong, Zhan-Bo; Xiang, Liping; Zheng, Xin-Qiang; Lu, Jian-Liang; Yuan, Cong-Bo; Ye, Jian-Hui; Liang, Yue-Rong

doi:10.3390/molecules22050849

Cited by 95 publications

(64 citation statements)

References 143 publications

(164 reference statements)

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“…It has been seen that treatment with GTE powder brought down FBGL from a higher value on the 14 th day. The results are in agreement with the other worker 18 .…”

Section: Discussionsupporting

confidence: 93%

Untitled

2019

IJPSR

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Diabetes mellitus is a lasting metabolic disability regarding enhance etiology and permanent degenerating complications. Sexual abnormalities (Hypogonadism, infertility, etc.) are outfit a two of the discombobulate ingenious stringency of diabetes mellitus. Different hypoglycemic agents are used to control diabetes mellitus, but very few formulations are available to treat secondary complications. Results of the present study establish the anti-diabetic properties of Camellia sinensis and its impact on the male reproductive systems of the streptozotocin-induced diabetic male rat. INTRODUCTION: Diabetes mellitus (DM) is a disease that deals with a chronic metabolic disorder involving carbohydrate, lipid, and protein by the occurrence of insulin scarce or disorder. Other conditions like arteriosclerosis (hardening and loss of elasticity of the wall of arteries), nephropathy (kidney damage), neuropathy (peripheral nerve dysfunction), and micro-angiopathy (thickening and weakening of capillary walls) can also be devoted through DM 1. It is also associated with an increased incidence of cardiovascular disease, reduced life expectancy, giant morbidity due to specific diabetes-associated microvascular complications and dwindled high-quality lifestyles 2 .

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“…It has been seen that treatment with GTE powder brought down FBGL from a higher value on the 14 th day. The results are in agreement with the other worker 18 .…”

Section: Discussionsupporting

confidence: 93%

Untitled

2019

IJPSR

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“…Furthermore, experimental studies have discovered that several bioactive components, including catechins, gallic acid, polysaccharides and epigallocatechin-3-gallate, within tea show antioxidant activity (28,29) and improve insulin sensitivity (30) . The polysaccharides extracted from fully fermented black tea and dark tea contain a higher percentage of low molecular weight portions (antioxidants) than those extracted from green tea and oolong tea, resulting in more benefits to T2DM (9) . According to Bhupathiraju et al, the effect of tea on diabetes might be attributed to caffeine.…”

Section: Discussionmentioning

confidence: 99%

“…The predominant bioactive substance contained in tea, for example, catechin, caffeine, thearubigins and polyphenols, has been suggested to have anti-diabetic effects in diabetic mice (9) . In addition, researches (10,11) reported that tea consumption could prevent the development of obesity, T2DM and cancer.…”

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confidence: 99%

Tea consumption and risk of diabetes in the Chinese population: a multi-centre, cross-sectional study

Chen

Qiu

et al. 2019

Br J Nutr

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The aim of the present study was to explore the influence of tea consumption on diabetes mellitus in the Chinese population. This multi-centre, cross-sectional study was conducted in eight sites from south, east, north, west and middle regions in China by enrolling 12 017 subjects aged 20–70 years. Socio-demographic and general information was collected by a standardised questionnaire. A standard procedure was used to measure anthropometric characteristics and to obtain blood samples. The diagnosis of diabetes was determined using a standard 75-g oral glucose tolerance test. In the final analysis, 10 825 participants were included and multiple logistic models and interaction effect analysis were applied for assessing the association between tea drinking with diabetes. Compared with non-tea drinkers, the multivariable-adjusted OR for newly diagnosed diabetes were 0·80 (95 % CI 0·67, 0·97), 0·88 (95 % CI 0·71, 1·09) and 0·86 (95 % CI 0·67, 1·11) for daily tea drinkers, occasional tea drinkers and seldom tea drinkers, respectively. Furthermore, drinking tea daily was related to decreased risk of diabetes in females by 32 %, elderly (>45 years) by 24 % and obese (BMI > 30 kg/m2) by 34 %. Moreover, drinking dark tea was associated with reduced risk of diabetes by 45 % (OR 0·55; 95 % CI 0·42, 0·72; P < 0·01). The results imply that drinking tea daily was negatively related to risk of diabetes in female, elderly and obese people. In addition, drinking dark tea was associated with decreased risk of type 2 diabetes mellitus.

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“…It was reported that there were nearly 4000 bioactive compounds in tea and one third was contributed by polyphenols [2,3]. Studies have shown that drinking teas can prevent cancer [4], alleviate oxidative stress, and suppress hyperglycemia and antidiabetic effect [5].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Ultraviolet A/B Treatments on Anthocyanin Accumulation and Gene Expression in Dark-Purple Tea Cultivar ‘Ziyan’ (Camellia sinensis)

et al. 2020

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‘Ziyan’ is a novel anthocyanin-rich tea cultivar with dark purple young shoots. However, how its anthocyanin accumulation is affected by environmental factors, such as ultraviolet (UV), remains unclear. In this study, we observed that UV light treatments stimulated anthocyanin accumulation in ‘Ziyan’ leaves, and we further analyzed the underlying mechanisms at gene expression and enzyme activity levels. In addition, the catechins and chlorophyll contents of young shoots under different light treatments were also changed. The results showed that the contents of total anthocyanins and three major anthocyanin molecules, i.e., delphinidin, cyanidin, and pelargonidin, were significantly higher in leaves under UV-A, UV-B, and UV-AB treatments than those under white light treatment alone. However, the total catechins and chlorophyll contents in these purple tea plant leaves displayed the opposite trends. The anthocyanin content was the highest under UV-A treatment, which was higher by about 66% than control. Compared with the white light treatment alone, the enzyme activities of chalcone synthase (CHS), flavonoid 3′,5′-hydroxylase (F3′5′H), and anthocyanidin synthase (ANS) under UV treatments increased significantly, whereas the leucoanthocyanidin reductase (LAR) and anthocyanidin reductase (ANR) activities reduced. There was no significant difference in dihydroflavonol 4-reductase (DFR) activity under all treatments. Comparative transcriptome analyses unveiled that there were 565 differentially expressed genes (DEGs) of 29,648 genes in three pair-wise comparisons (white light versus UV-A, W vs. UV-A; white light versus UV-B, W vs. UV-A; white light versus UV-AB, W vs. UV-AB). The structural genes in anthocyanin pathway such as flavanone 3-hydroxylase (F3H), F3′5′H, DFR, and ANS, and regulatory gene TT8 were upregulated under UV-A treatment; F3′5′H, DFR, ANS, and UFGT and regulatory genes EGL1 and TT2 were upregulated under UV-AB treatment. However, most structural genes involved in phenylpropanoid and flavonoid pathways were downregulated under UV-B treatment compared with control. The expression of LAR and ANR were repressed in all UV treatments. Our results indicated that UV-A and UV-B radiations can induce anthocyanin accumulation in tea plant ‘Ziyan’ by upregulating the structural and regulatory genes involved in anthocyanin biosynthesis. In addition, UV radiation repressed the expression levels of LAR, ANR, and FLS, resulting in reduced ANR activity and a metabolic flux shift toward anthocyanin biosynthesis.

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Antidiabetic Effects of Tea

Cited by 95 publications

References 143 publications

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Tea consumption and risk of diabetes in the Chinese population: a multi-centre, cross-sectional study

The Effects of Ultraviolet A/B Treatments on Anthocyanin Accumulation and Gene Expression in Dark-Purple Tea Cultivar ‘Ziyan’ (Camellia sinensis)

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