Tape’n roll inertial microfluidics

Asghari, Mohammad Hossein; Serhatlıoğlu, Murat; Saritas, Resul; Güler, Mustafa Tahsin; Elbüken, Çağlar

doi:10.1016/j.sna.2019.111630

Cited by 15 publications

(6 citation statements)

References 52 publications

(65 reference statements)

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“…These tubes can also be used as force sensors due to the high sensitivity of the flexible structure. The second technique for fabricating 3D flexible spiral microchannels is making planar 2D microchannels and then coiling them around a rod into 3D structures (Figure 9a) [172]. Also, Jung et al [90] have proposed an interesting method in producing 3D microchannels by simply bending a flexible planer microfluidic channel (Figure 9b).…”

Section: Effect Of Flexibility On Separationmentioning

confidence: 99%

Flexible Microfluidics: Fundamentals, Recent Developments, and Applications

et al. 2019

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Miniaturization has been the driving force of scientific and technological advances over recent decades. Recently, flexibility has gained significant interest, particularly in miniaturization approaches for biomedical devices, wearable sensing technologies, and drug delivery. Flexible microfluidics is an emerging area that impacts upon a range of research areas including chemistry, electronics, biology, and medicine. Various materials with flexibility and stretchability have been used in flexible microfluidics. Flexible microchannels allow for strong fluid-structure interactions. Thus, they behave in a different way from rigid microchannels with fluid passing through them. This unique behaviour introduces new characteristics that can be deployed in microfluidic applications and functions such as valving, pumping, mixing, and separation. To date, a specialised review of flexible microfluidics that considers both the fundamentals and applications is missing in the literature. This review aims to provide a comprehensive summary including: (i) Materials used for fabrication of flexible microfluidics, (ii) basics and roles of flexibility on microfluidic functions, (iii) applications of flexible microfluidics in wearable electronics and biology, and (iv) future perspectives of flexible microfluidics. The review provides researchers and engineers with an extensive and updated understanding of the principles and applications of flexible microfluidics.

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Section: Effect Of Flexibility On Separationmentioning

confidence: 99%

Flexible Microfluidics: Fundamentals, Recent Developments, and Applications

et al. 2019

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“…A circular spiral channel may further evolve into a rectangle and even into a 3D structure. Asghari et al fabricated a 3D spiral structure by applying a “tape’n roll” method 132 . This method overcomes the fabrication difficulty of conventional 3D structures.…”

Section: Different Biological Micro-object Separation Microfluidic Sc...mentioning

confidence: 99%

Geometric structure design of passive label-free microfluidic systems for biological micro-object separation

et al. 2022

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Passive and label-free microfluidic devices have no complex external accessories or detection-interfering label particles. These devices are now widely used in medical and bioresearch applications, including cell focusing and cell separation. Geometric structure plays the most essential role when designing a passive and label-free microfluidic chip. An exquisitely designed geometric structure can change particle trajectories and improve chip performance. However, the geometric design principles of passive and label-free microfluidics have not been comprehensively acknowledged. Here, we review the geometric innovations of several microfluidic schemes, including deterministic lateral displacement (DLD), inertial microfluidics (IMF), and viscoelastic microfluidics (VEM), and summarize the most creative innovations and design principles of passive and label-free microfluidics. We aim to provide a guideline for researchers who have an interest in geometric innovations of passive label-free microfluidics.

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“…The capability of separating smaller particles in a larger channel makes the channels less prone to clogging and reduces the pressure drop through the channel, thus reducing the pumping requirements. Asghari et al 33 used flexible PDMS wrapped around a rod to demonstrate streamlines for 6 μm particles in rectangular cross section helical channels (50 μm wide and 200 μm deep) with an inner channel diameter of 6 mm and helical pitches of 4 mm and 8 mm. Focusing was not achieved with a helical pitch of 4 mm, and particles were only focused at the center of the 8 mm pitch channel at flow rates between 0.33 and 0.67 ml/ min.…”

Section: Introductionmentioning

confidence: 99%

Lab on a rod: Size-based particle separation and sorting in a helical channel

et al. 2020

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Size-based particle separation using inertial microfluidics in spiral channels has been well studied over the past decade. Though these devices can effectively separate particles, they require a relatively large device footprint with a typical outer channel radius of approximately 15 mm. In this paper, we describe a microfluidic device with a footprint diameter of 5.5 mm, containing a helical channel capable of inertial particle separation fabricated using abrasive jet micromachining. The separation of particles in several channel geometries was studied using wide-field fluorescence microscopy. A maximum separation efficiency of approximately 90% was achieved at a flow rate of 1.5 ml/min with a purity of approximately 95% at the outlet, where large particles were collected. An accompanying computational fluid dynamics model was developed to allow researchers to quickly assess the separation capability of their helical or spiral devices.

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Tape’n roll inertial microfluidics

Cited by 15 publications

References 52 publications

Flexible Microfluidics: Fundamentals, Recent Developments, and Applications

Flexible Microfluidics: Fundamentals, Recent Developments, and Applications

Geometric structure design of passive label-free microfluidic systems for biological micro-object separation

Lab on a rod: Size-based particle separation and sorting in a helical channel

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