Tantalum – Poly (L-lactic acid) nerve conduit for peripheral nerve regeneration

Almansoori, Akram Abdo; Hwang, Changha; Lee, Sungho; Kim, Bongju; Kim, Hyoun‐Ee; Lee, Jong-Ho

doi:10.1016/j.neulet.2020.135049

Cited by 10 publications

(6 citation statements)

References 16 publications

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“…203 In a recent study, electrospun PLLA was coated with tantalum (Ta) to develop an NGC, which was found to stimulate the proliferation of SCs and enable the restoration of peripheral nerves without the generation of scar tissue (Figure 15). 204 Several notable research efforts to fabricate NGCs from piezoelectric polymers are summarized in Table 3.…”

Section: Poly-l-lactic Acidmentioning

confidence: 99%

Review on electrically conductive smart nerve guide conduit for peripheral nerve regeneration

Rahman

Dip

Padhye

et al. 2023

J Biomedical Materials Res

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At present, peripheral nerve injuries (PNIs) are one of the leading causes of substantial impairment around the globe. Complete recovery of nerve function after an injury is challenging. Currently, autologous nerve grafts are being used as a treatment; however, this has several downsides, for example, donor site morbidity, shortage of donor sites, loss of sensation, inflammation, and neuroma development. The most promising alternative is the development of a nerve guide conduit (NGC) to direct the restoration and renewal of neuronal axons from the proximal to the distal end to facilitate nerve regeneration and maximize sensory and functional recovery. Alternatively, the response of nerve cells to electrical stimulation (ES) has a substantial regenerative effect. The incorporation of electrically conductive biomaterials in the fabrication of smart NGCs facilitates the function of ES throughout the active proliferation state. This article overviews the potency of the various categories of electroactive smart biomaterials, including conductive and piezoelectric nanomaterials, piezoelectric polymers, and organic conductive polymers that researchers have employed latterly to fabricate smart NGCs and their potentiality in future clinical application. It also summarizes a comprehensive analysis of the recent research and advancements in the application of ES in the field of NGC.

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Section: Poly-l-lactic Acidmentioning

confidence: 99%

Review on electrically conductive smart nerve guide conduit for peripheral nerve regeneration

Rahman

Dip

Padhye

et al. 2023

J Biomedical Materials Res

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“…7 In contrast to anatomical limitations in the upper limb, the distal part of the injured Nerve connectors are evolving. 8 There have been debates over advantages and disadvantage of nerve grafting compared to connector-assisted nerve repair, and there certainly have been evidences showing benefits of connector-assisted nerve repair techniques recently. 9,10 On the other side, when the nerve can be directly repaired with minimal tension of less than 25 grams, it is still believed advantageous to perform direct nerve repair.…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting Functional Sensory Recovery After Inferior Alveolar Nerve Repair Using the Nerve Sliding Technique

Kang

Almansoori

Chae

et al. 2021

Journal of Oral and Maxillofacial Surgery

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Tantalum (Ta) has recently been recognized as another promising metal in managing soft tissue lesions [ 151 ]. In this regard, Mendonca et al [ 140 ] synthesized Ta-containing MBGs ((80 − x)SiO 2 –15CaO–5P 2 O 5 –xTa 2 O 5 (mol.%) by the EISA method.…”

Section: Mbgs For Skin Cancer Therapymentioning

confidence: 99%

Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy

et al. 2021

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Exploring new therapies for managing skin wounds is under progress and, in this regard, mesoporous silica nanoparticles (MSNs) and mesoporous bioactive glasses (MBGs) offer great opportunities in treating acute, chronic, and malignant wounds. In general, therapeutic effectiveness of both MSNs and MBGs in different formulations (fine powder, fibers, composites etc.) has been proved over all the four stages of normal wound healing including hemostasis, inflammation, proliferation, and remodeling. The main merits of these porous substances can be summarized as their excellent biocompatibility and the ability of loading and delivering a wide range of both hydrophobic and hydrophilic bioactive molecules and chemicals. In addition, doping with inorganic elements (e.g., Cu, Ga, and Ta) into MSNs and MBGs structure is a feasible and practical approach to prepare customized materials for improved skin regeneration. Nowadays, MSNs and MBGs could be utilized in the concept of targeted therapy of skin malignancies (e.g., melanoma) by grafting of specific ligands. Since potential effects of various parameters including the chemical composition, particle size/morphology, textural properties, and surface chemistry should be comprehensively determined via cellular in vitro and in vivo assays, it seems still too early to draw a conclusion on ultimate efficacy of MSNs and MBGs in skin regeneration. In this regard, there are some concerns over the final fate of MSNs and MBGs in the wound site plus optimal dosages for achieving the best outcomes that deserve careful investigation in the future.

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Tantalum – Poly (L-lactic acid) nerve conduit for peripheral nerve regeneration

Cited by 10 publications

References 16 publications

Review on electrically conductive smart nerve guide conduit for peripheral nerve regeneration

Review on electrically conductive smart nerve guide conduit for peripheral nerve regeneration

Factors Affecting Functional Sensory Recovery After Inferior Alveolar Nerve Repair Using the Nerve Sliding Technique

Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy

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