Tannins from <i>Terminalia chebula</i> fruits attenuates GABA antagonist-induced anxiety-like behaviour <i>via</i> modulation of neurotransmitters

Yadavalli, Chandra Sekhar; Kumar, G. Phani; Navya, K.; Ramya, E. M.

doi:10.1111/jphp.13007

Cited by 25 publications

(11 citation statements)

References 44 publications

(75 reference statements)

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“…Additionally, the treatment of the same extract showed the significant anxiolytic activity against picrotoxin-induced anxiety model. 47 The present study indicated elevation of monoamine neurotransmitters by inhibition of brain MAO-A levels at the dose level of 200 mg/kg of the T.chebula extract treatment. This beneficial activity might be correlated with the presence of tannin rich compounds in T.chebula fruits.…”

Section: Discussionsupporting

confidence: 56%

Anxiolytic-like and antidepressant-like effects of ethanol extract of Terminalia chebula in mice

Mani

Sajid

Rabbani

et al. 2021

Journal of Traditional and Complementary Medicine

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Terminalia chebula (T.chebula) fruit is referred as “King of Medicines” in Tibet and is listed as a key plant in “Ayurvedic Materia Medica” due to its diverse pharmacological activity. The present study was aimed to investigate the comorbid antidepressant-like and anxiolytic-like effects of ethanol extract from T.chebula fruit using experimental behavioral tests in mice. In addition, the study explored the effects of extract on monoamine oxidase –A (MAO-A) levels in mouse brain. Two doses of the T.chebula extract (100 or 200 mg/kg, p.o.) were treated continuously for fifteen days to mice. Regarding antidepressant-like effects, the treatment of T.chebula extract at both dose (100 or 200 mg/kg, p.o.) levels resulted with significant (p < 0.001) reduction in duration of immobility time and increase in swimming time as compared to control group in forced swimming test. Moreover, both doses declined the duration of immobility time in the tail suspension test and increased the number of crossing in the center area using open-field test. Additionally, the dose 200 mg/kg treatment showed a significant reduction (p < 0.05) in MAO-A activity in mouse brain. For anxiolytic activity, both doses significantly (p < 0.001) improved the time spent in open arm and the number of head dips in elevated plus maze test. The higher duration of time spent in light chamber and higher number of crossing between the light and dark chambers by extract treatment in light-dark box test also supported the anxiolytic behavior. The obtained results supported the antidepressant-like and anxiolytic-like effects of ethanol extract of T.chebula in mice.

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Section: Discussionsupporting

confidence: 56%

Anxiolytic-like and antidepressant-like effects of ethanol extract of Terminalia chebula in mice

Mani

Sajid

Rabbani

et al. 2021

Journal of Traditional and Complementary Medicine

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“…In an animal study, Gupta et al reported that the hydroalcoholic extract of black myrobalan has anticonvulsant effects, enhances the effects of antiepileptic drugs, improves cognitive symptoms, and shows antioxidant effects (Kumar, Arora, Agarwal, & Gupta, 2018). In another animal study, Kumar et al demonstrated that the tannin‐rich extract of black myrobalan could neutralize picrotoxin's stressful effects by activating the GABAergic (gamma‐aminobutyric acid) pathway and could be used in the treatment of neurodegenerative diseases (Chandrasekhar, Phani Kumar, Navya, Ramya, & Anilakumar, 2018). These effects (related to Gupta et al and Kumar et al's studies) could aid in the negative and behavioral symptoms (excitement/ activity) of patients with schizophrenia by activating GABAergic mediated neurons (Shaw et al, 2020) and could also help explain the confusion observed in one of the patients due to possible interaction with the GABAergic or antiepileptic drugs that were being taken by the patient.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the effect of black myrobalan on cognitive, positive, and negative symptoms in patients with chronic schizophrenia: A randomized, double‐blind, placebo‐controlled trial

Banazadeh

Mehrabani

Banazadeh

et al. 2021

Phytotherapy Research

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Schizophrenia, as a chronic and disabling mental disorder, causes a wide range of symptoms, including cognitive impairments, positive, negative, and mood symptoms. There are no effective treatments for cognitive symptoms. Black myrobalan (Terminalia chebula Retz.), a medicinal plant of the Combretaceae family, exerts antioxidant, antiacetylcholinesterase, and anti‐inflammatory effects. These effects can lessen the symptoms of schizophrenia. So, this study was conducted to evaluate black myrobalan's impact on cognitive impairments and negative/positive symptoms in patients with chronic schizophrenia. This was a randomized, double‐blind, placebo‐controlled clinical trial in which participants were divided into treatment and placebo groups. They received six 500 mg capsules of black myrobalan or placebo in two divided doses for 4 weeks. Patients' cognitive impairments, positive, negative, depression/anxiety, and excitement/activity symptoms were assessed using the Screen for Cognitive Impairments in Psychiatry (SCIP) and the relevant subscales of the Positive and Negative Syndrome Scale (PANSS) pretreatment and 4 weeks after treatment. Cognitive impairments (SCIP) (p value .004), negative symptoms (PANSS subscale) (p value .017), and excitement/activity (PANSS subscale) (p value .003) were significantly improved in the black myrobalan group compared with the control group after 4 weeks. No serious adverse effects were reported. Black myrobalan could improve cognitive impairments, negative and excitement/activity symptoms in chronic schizophrenic patients.

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“…[26,28] Aqueous extract of Haritaki is found to have a good anxiolytic and antidepressant activity when evaluated against standard drug diazepam and imipramine respectively [29][30]. Tanin rich extract of Haritaki resulted in downregulation of serum cortisol level and maintained the level of 5HT and dopamine in the blood presenting anxiolytic activity [31]. Phytoconstituents found in Haritaki have a good therapeutic effect with no toxicity [32].…”

Section: Recent Researches and Evidence On Research Drugsmentioning

confidence: 99%

Evaluation of Comparative Efficacy of Brahmi vs. Haritaki Extract in the Management of Academic Stress in Adolescent Students- A Prakriti based Double-blind Randomized Controlled Trial

Pandey

Rathi

et al. 2021

JPRI

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Introduction: Prevalence of mental illnesses among adolescents was found 7.3% (N=1191) by NMHS survey 2015-16 whereas the national crime record bureau in 2014 stated 1.8% of students committed suicide due to failure in their exams. The root cause, that is academic stress is often ignored which occurred due to various stressors like physical, mental, family, school, relationship, and social factors of which School factor (56.7%) and academic tests (45.6%) hold maximum association. Proper management can be provided with Ayurveda by Prakriti wise (exploring one physical, physiological and psychological factors) analysis of stress and their coping up strength and effect, when assisted with oral intakes of Ayurveda drugs like Brahmi and Haritaki along with Sattvavajaya Chikitsa having Achar Rasayana, Surya Namaskar, Dharna, and Dhyana practices. Aim and Objectives: The aim is to evaluate the comparative efficacy of Brahmi extract with Sattvavajaya Chikitsa over the effect of Haritaki extract with Sattvavajaya Chikitsa in the management of Academic Stress among adolescent students of different Prakriti. Material and Methods: A double-blind reference standard controlled stratified randomized superiority clinical trial is planned. The sample size of 198 participants with 13% dropout consideration will be enrolled after analysis of their Prakriti and stress level between 5-25 according to the SAAS scale. Total 6 subgroups (3 each for trial drug group and 3 for standard control) will have Vata, Pitta, and Kapha Doshic (V, P & K) dominant Prakriti participants of 10 to 17years of age. Total 33 participants in each subgroup will have the interventions for 90 days. Observation and Results: Participants will be assessed for changes in salivary cortisol, level of academic stress, IQ, and memory before and after the trial. The standard descriptive and inferential statistical measures will be used to assess the effect of interventions. Conclusion: Prakriti analysis will help stressed adolescents to know their strengths and interventions provided will be expected to help a stressed one to minimize stress level and also assist in developing their stress-coping mechanism.

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Tannins from Terminalia chebula fruits attenuates GABA antagonist-induced anxiety-like behaviour via modulation of neurotransmitters

Abstract: Terminalia chebula tannin-rich extract showed significant anxiolytic activity against picrotoxin and could be used as natural therapy in neurodegenerative disorders.

Cited by 25 publications

References 44 publications

Anxiolytic-like and antidepressant-like effects of ethanol extract of Terminalia chebula in mice

Anxiolytic-like and antidepressant-like effects of ethanol extract of Terminalia chebula in mice

Evaluating the effect of black myrobalan on cognitive, positive, and negative symptoms in patients with chronic schizophrenia: A randomized, double‐blind, placebo‐controlled trial

Evaluation of Comparative Efficacy of Brahmi vs. Haritaki Extract in the Management of Academic Stress in Adolescent Students- A Prakriti based Double-blind Randomized Controlled Trial

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