Tannic acid suppresses ultraviolet B-induced inflammatory signaling and complement factor B on human retinal pigment epithelial cells

Chou, Wen Wen; Wang, Yung Song; Chen, Ku Chung; Wu, Jing; Liang, Chung Ling; Juo, Suh Hang Hank

doi:10.1016/j.cellimm.2011.11.003

Cited by 31 publications

(24 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…And the effects of HIF-1α, EPO and VEGF on cell survival likely involve the expression of JAK2/STAT3 signal pathway, which plays a crucial role in regulation of inflammatory reaction [13], the growth and differentiation of cells [14], and cells apoptosis [15]. IL-6 is a member of the neuropoietin family of cytokines which includes leukemia inhibitory factor, ciliary neurotrophic factor, cardiotrophin oncostatin M, and IL-11 [16,17].…”

Section: Introductionmentioning

confidence: 99%

Midazolam Inhibits the Apoptosis of Astrocytes Induced by Oxygen Glucose Deprivation via Targeting JAK2-STAT3 Signaling Pathway

Liu

You²,

Tu³

et al. 2015

Cell Physiol Biochem

View full text Add to dashboard Cite

Background: There is an increasing interest in the role of astrocytes contributing to the intrinsic bioremediation of ischemic brain injury. The purpose of this study was to disclose the effects and mechanism of midazolam (MDZ) on the proliferation and apoptosis of astrocytes under oxygen glucose deprivation (OGD) condition. Methods: The astrocytes were assigned randomly into four groups: control group, OGD group, OGD+MDZ group, and OGD+MDZ+IL-6 group. The astrocytes were treated with MDZ at dose of 10 μmol/L in OGD+MDZ group. And in OGD+MDZ+IL-6 group, the astrocytes were treated with MDZ at dose of 10μmol/L and IL-6 at dose of 50 ng/mL. MTT assay was used to assess cell proliferation, and cell apoptosis was analyzed by TUNEL apoptosis assay kit and flow cytometry. Furthermore, the expression of JAK2, p-JAK2, STAT3, p-STAT3, Bcl-2, Bax and Caspase-3 proteins were determined by western blotting assay. Results: Astrocytes proliferation was decreased obviously in OGD group, while MDZ could increase astrocytes proliferation under OGD condition. Moreover, OGD could induce apoptosis in astrocytes and MDZ could play an anti-apoptotic role. However, IL-6, a JAK2 activator, could attenuate cell proliferation and anti-apoptotic effects of MDZ in astrocytes. In addition, the expression of Bcl-2 protein in MDZ group increased markedly, while the JAK2/STAT3 signal proteins, Bax and Caspase-3 proteins decreased relative to OGD group. But IL-6 could counteract the anti-apoptotic effects of MDZ. Conclusion: Midazolam has protective effects on the proliferation and apoptosis of astrocytes via JAK2/STAT3 signal pathway in vitro. We firstly disclose the beneficial roles of midazolam in astrocytes under ischemic condition, which may be a rational treatment selection for ischemic cerebral protection.

show abstract

Section: Introductionmentioning

confidence: 99%

Midazolam Inhibits the Apoptosis of Astrocytes Induced by Oxygen Glucose Deprivation via Targeting JAK2-STAT3 Signaling Pathway

Liu

You²,

Tu³

et al. 2015

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…Furthermore, CFB is implicated in an ultraviolet B-induced inflammatory response in human retinal pigment epithelium cells. 45 Recent descriptions of associations between AMD and a number of complement-associated gene variants strongly support this inflammatory model of AMD pathogenesis. 46 Findings related to the genotype-phenotype correlation of CFB and CFH variants with drusen characteristics in AMD fit this model well, thus creating a link between genetic, histological and clinical findings.…”

Section: Discussionmentioning

confidence: 92%

Complement Factor B Polymorphism and the Phenotype of Early Age-related Macular Degeneration

Mantel

Ambresin

Moetteli

et al. 2013

Ophthalmic Genetics

View full text Add to dashboard Cite

The CFB (R32Q) polymorphism was associated with AMD characterized by small drusen only, and appeared to be protective of large drusen (OR 0.48/0.45) and of larger drusen covered area (OR 0.34). Furthermore, peripheral drusen were more frequently found (OR 2.27). This result supports the role of complement components and their polymorphisms in drusen formation and may enable a better understanding of AMD pathogenesis.

show abstract

“…These findings imply that STAT3 is indeed a novel potential target to prevent UVB radiation-induced inflammatory skin damages. Previous report has demonstrated that tannic acid prevents UVB-induced STAT3 expression in human retinal pigment epithelium cells (Chou et al 2012). It was also reported topical or dietary silibinin can strongly protect against UVB exposure by down-regulating inflammatory and angiogenic responses through inhibition of STAT3 phosphorylation (Gu et al 2007).…”

Section: Discussionmentioning

confidence: 98%

Inhibitory effect of Carnosol on UVB-induced inflammation via inhibition of STAT3

et al. 2018

View full text Add to dashboard Cite

Ultraviolet B (UVB) irradiation causes sunburn, inflammatory responses, dysregulation of immune function, oxidative stress, DNA damage and photocarcinogenesis on skin. Rosemary (Rosmarinus officinalis L.) has been reported to inhibit inflammation. Carnosol, a major component of Rosemary, has prominent anti-inflammatory effects. However, its protective effect on UVB-induced inflammatory skin responses has not yet been reported. Here, we investigated the effectiveness of carnosol on UVB-induced inflammation. We examined the anti-inflammation effect of topical application of carnosol (0.05 µg/cm2) on UVB (540 mJ/cm2, for 3 successive days)-induced skin inflammation in HR1 mice. Topical application of carnosol inhibited UVB-induced erythema, epidermal thickness, inflammatory responses in HR1 mice. Carnosol reduced the level of Immunoglobulin-E and IL-1β in blood serum of UVB-induced mice. Carnosol also significantly inhibited the UVB-induced expression of inflammatory marker protein (iNOS and COX-2) in back skin of mice. In addition, carnosol treated skin decreased activation of STAT3, a transcriptional factor regulating inflammatory genes. Our study suggested that carnosol has protective effects on skin inflammatory skin damages by UVB.

show abstract

Tannic acid suppresses ultraviolet B-induced inflammatory signaling and complement factor B on human retinal pigment epithelial cells

Cited by 31 publications

References 38 publications

Midazolam Inhibits the Apoptosis of Astrocytes Induced by Oxygen Glucose Deprivation via Targeting JAK2-STAT3 Signaling Pathway

Midazolam Inhibits the Apoptosis of Astrocytes Induced by Oxygen Glucose Deprivation via Targeting JAK2-STAT3 Signaling Pathway

Complement Factor B Polymorphism and the Phenotype of Early Age-related Macular Degeneration

Inhibitory effect of Carnosol on UVB-induced inflammation via inhibition of STAT3

Contact Info

Product

Resources

About