Inhibitory effect of Carnosol on UVB-induced inflammation via inhibition of STAT3

Yeo, In Jun; Park, Ju Ho; Jang, Jun Sung; Lee, Doyeon; Park, Jung Eun; Choi, Ye Eun; Joo, Jung Hun; Song, Joo Kyung; Jeon, Hyung Ok; Hong, Jin Tae

doi:10.1007/s12272-018-1088-1

Cited by 26 publications

(17 citation statements)

References 46 publications

(48 reference statements)

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“…This UVB-induced photodamage results from acute inflammatory responses, such as an increase in proinflammatory cytokines (e.g., IL-6 and IL-1 β ) [ 4 , 12 , 13 ], and the blood and lymphatic vasculature play an important role in the progression of inflammation. UVB irradiation induces vascular hyperpermeability and blood vessel dilation via production of prostaglandin E2 (PGE2) [ 14 ], resulting in increased extravasated fluid including excess water, macromolecules, and inflammatory cells.…”

Section: Introductionmentioning

confidence: 99%

Saireito Improves Lymphatic Function and Prevents UVB-Induced Acute Inflammation and Photodamage in HR-1 Hairless Mice

Oyama¹,

Murata²,

Ogata³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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A single high-dose ultraviolet B (UVB) exposure on the skin induces acute inflammatory responses, such as an increase in proinflammatory cytokines (e.g., IL-6 and IL-1β), hyperpermeability and dilation of blood and lymphatic vessels, and infiltration of inflammatory cells. These responses result in different cutaneous disorders characterized by erythema, epidermal hyperplasia, edema formation, and extracellular matrix degradation. Saireito extract (SRT), a traditional Chinese medicine, has been used to treat various inflammatory diseases in Japan, and SRT and its major active components (e.g., saikosaponins and baicalin) were reported to downregulate proinflammatory cytokines. Moreover, SRT has a protective effect against UV irradiation in vitro. Based on these findings, we aimed to investigate the effect of SRT on UVB-induced photodamage and structural change in the vasculature. We pretreated male HR-1 hairless mice with SRT (625 or 1250 mg/kg) for 3 weeks before a single UVB (250 mJ/cm2) irradiation. SRT treatment attenuated UVB-induced increases in erythema, transepidermal water loss, and edema formation at 72 h after irradiation. SRT treatment also suppressed UVB-induced inflammatory cell infiltration and collagen degradation. Furthermore, at 24 h after irradiation, SRT treatment inhibited UVB-induced upregulation of proinflammatory cytokines and reduction in lymphatic vessel density associated with upregulation of VEGF-C expression. These results suggest that SRT could attenuate UVB-induced photodamage. This protective effect of SRT involves suppression of upregulation of proinflammatory cytokines and improvement of lymphatic function in the early stage of inflammation.

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Section: Introductionmentioning

confidence: 99%

Saireito Improves Lymphatic Function and Prevents UVB-Induced Acute Inflammation and Photodamage in HR-1 Hairless Mice

Oyama¹,

Murata²,

Ogata³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…It has been demonstrated that carnosic acid and, which are the most abundant compounds in R. officinalis leaves, considerably reduce the expression of IL-1β, TNF-α, and COX-2 [10]. In one study, it was shown that carnosol extracted from R. officinalis had anti-inflammatory and anti-fibrotic effects against ultraviolet B irradiation-induced skin inflammation, fibrosis, erythema, and epidermal thickness in HR1 mice through decreased activation of STAT3, a transcriptional factor regulating inflammatory genes [11].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effects of Peritoneal Lavage with Rosmarinus officinalis Extract against the Prevention of Postsurgical-Induced Peritoneal Adhesion

et al. 2020

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Postoperative adhesions are regarded as the major complication following abdominal surgery. Rosmarinus officinalis has shown antioxidative and anti-inflammatory effects. Therefore, we aimed to assess the influence of 70% v/v hydro-ethanolic extract of the aerial parts of R. officinalis against postoperative abdominal adhesions in a rat model. Forty-eight male Wistar rats (190 ± 20 g) were divided into six groups of eight: group 1 = normal group, without any surgical procedures, group 2 = control group, group 3 = vehicle group, and groups 3, 4, and 5 = experimental groups receiving 2 mL of 4, 2, or 1% w/v R. officinalis treatment. Adhesion levels were macroscopically examined. Additionally, the levels of inflammatory cytokines (interleukin-6, interleukin-1β, and TNF-α), growth factors (transforming growth factor-β1, and vascular endothelial growth factor), oxidative (NO, nitric oxide and MDA, malondialdehyde), and antioxidative (GSH, glutathione) factors were evaluated. Our results revealed that the adhesion score, interleukin-6, interleukin-1β, TNF-α, transforming growth factor-β1, vascular endothelial growth factor, NO, and MDA levels were significantly increased in the vehicle group, while the GSH level was diminished. R. officinalis treatment notably ameliorated the adhesion score following postoperative abdominal adhesions compared with the vehicle group. Our results also revealed that R. officinalis markedly reduced inflammatory cytokines, oxidative factors, fibrosis, and angiogenesis biomarkers, whereas it increased the antioxidative factor. Therefore, R. officinalis may be a potential candidate for the management of postoperative peritoneal adhesion.

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“…The anti-allergic effect of carnosol has also been observed in other Th2 cell-related diseases. In skin pharmacology, topical application of carnosol has been reported in PMA-induced ear edema, phthalic anhydride-induced atopic dermatitis, and UVB-induced inflammation ( Mengoni et al ., 2011 ; Lee et al ., 2017 ; Yeo et al ., 2019 ). Carnosol reduced the expression of IL-1β and TNF-α and inhibited COX-2 in PMA-induced ear inflammation in vivo ( Mengoni et al ., 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Suppressive Effect of Carnosol on Ovalbumin-Induced Allergic Asthma

Jung-Eun

2021

Biomolecules & Therapeutics

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Asthma is a chronic obstructive lung disease characterized by recurrent episodes of bronchoconstriction and wheezing. Conventional asthma treatment involves the suppression of airway inflammation or improving airway flow. Rosmarinus officialis , also known as rosemary, is a Mediterranean plant that is used for the treatment of inflammatory diseases. Carnosol, a diterpenoid found in rosemary extracts, has been known to exhibit anti-inflammatory, anti-tumor, and anti-oxidant effects. The effect of carnosol on allergic responses has not been tested yet. The effect of carnosol on a murine allergic asthma model were investigated. Carnosol inhibited the degranulation of RBL-2H3 mast cells. Carnosol treatment inhibited the increase in the number of eosinophils in the bronchoalveolar lavage fluids (BALF) of mice treated with ovalbumin. Carnosol treatment also inhibited inflammatory responses and mucin production in histologic studies. Carnosol treatment inhibited the increases of IL-4 and IL-13 cytokines expression in both BALF and the lungs. These results suggest that carnosol may have a potential for allergic asthma therapy.

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Inhibitory effect of Carnosol on UVB-induced inflammation via inhibition of STAT3

Cited by 26 publications

References 46 publications

Saireito Improves Lymphatic Function and Prevents UVB-Induced Acute Inflammation and Photodamage in HR-1 Hairless Mice

Saireito Improves Lymphatic Function and Prevents UVB-Induced Acute Inflammation and Photodamage in HR-1 Hairless Mice

Evaluation of the Effects of Peritoneal Lavage with Rosmarinus officinalis Extract against the Prevention of Postsurgical-Induced Peritoneal Adhesion

Suppressive Effect of Carnosol on Ovalbumin-Induced Allergic Asthma

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