Tannic acid mitigates the DMBA/croton oil-induced skin cancer progression in mice

Majed, Ferial; Rashid, Summya; Khan, Abdul Quaiyoom; Nafees, Sana; Ali, Nemat; Rashid, Asif; Khan, Rehan; Hasan, Syed Kazim; Mehdi, Syed Jafar; Sultana, Sarwat

doi:10.1007/s11010-014-2248-3

Cited by 23 publications

(25 citation statements)

References 55 publications

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“…Among which tannic acid, is a well-known polyphenol compound present in most of the fruits, vegetables, and plants, is reported to have potent anti-inflammatory, antioxidant, antimicrobial, antimutagenic and anticarcinogenic activities. Previous studies reported that tannic acid has promising clinical results against skin cancer [23], myocardial infarction [24], renal failure [25], hepatotoxicity/genotoxicity [26], diabetes [27] and Alzheimer disease [28]. Furthermore, tannic acid inhibited inflammatory cytokines and proinflammatory factors such as iNOS and COX2 [25].…”

Section: Discussionmentioning

confidence: 99%

Tannic acid modulates NFκB signaling pathway and skin inflammation in NC/Nga mice through PPARγ expression

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Tannic acid modulates NFκB signaling pathway and skin inflammation in NC/Nga mice through PPARγ expression

et al. 2015

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“…More recently, anti-promotional activity of TA in the mouse skin through the reduction of oxidative stress as well as COX-2, iNOS, PCNA (proliferating cell nuclear antigen) protein, and proinflammatory cytokine such as IL-6 release was confirmed [23]. Anti-inflammatory activity of TA was also shown in the context of house dust mite-induced atopic dermatitis.…”

Section: Chemosenstization and Impact On Multidrug Resistancementioning

confidence: 87%

Tannic Acid: Specific Form of Tannins in Cancer Chemoprevention and Therapy-Old and New Applications

et al. 2020

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Purpose of Review This short review is aimed at providing an updated and comprehensive report on tannic acid biological activities and molecular mechanisms of action most important for cancer prevention and adjuvant therapy. Recent Findings Tannic acid (TA), a mixture of digallic acid esters of glucose, is a common ingredient of many foods. The early studies of its anti-mutagenic and anti-tumorigenic activity were mostly demonstrated in the mouse skin model. This activity has been explained by its ability to inhibit carcinogens activation, as well as antioxidant and anti-inflammatory properties. Recently, the cell cycle arrest, apoptosis induction, reduced rate of proliferation, and cell migration and adhesion of several cancer cell lines as a result of TA treatment were described. The underlining mechanisms include modulation of signaling pathways such as EGFR/Jak2/STATs, or inhibition of PKM2 glycolytic enzyme. Moreover, epithelial-to-mesenchymal transition prevention and decrease of cancer stem cells formation by TAwere also reported. Besides, TAwas found to be potent chemosensitizer overcoming multidrug resistance. Eventually, its specific physicochemical features were found useful for generation of drug-loaded nanoparticles. Summary TA was shown to be a very versatile molecule with possible application not only in cancer prophylaxis, as was initially thought, but also in adjuvant cancer therapy. The latter may refer to chemosensitization and its application as a part of drug delivery systems. More studies are required to better explore this subject. In addition, the effect of TA on normal cells and its bioavailability have to better characterized.

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“…The anticarcinogenic potential of the crude venom extract obtained from L. quinquestriatus was evaluated using the classic DMBA/12- O -tetradecanoylphorbol-13-acetate or croton oil-induced two-stage mouse skin carcinogenesis model. 25 , 26 Animals were divided into five groups of 13 animals each. The dorsal skin of each animal was shaved with an electric clipper 2 days prior to initiation of the experiment.…”

Section: Methodsmentioning

confidence: 99%

Investigation of in vivo potential of scorpion venom against skin tumorigenesis in mice via targeting markers associated with cancer development

Asmari¹,

Khan²

2016

DDDT

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Cancer is the leading cause of morbidity and mortality all over the world in spite of the advances made in its management. In this study, we investigated the in vivo anti-tumorigenic potential of the venom obtained from a medically important scorpion species Leiurus quinquestriatus on chemically induced skin cancer in mice. Animals were divided into five groups, with 13 animals in each group. All the treatments were given topically on the shaved dorsal surface of the skin. Animals in Group 1 received vehicle only (0.2 mL acetone). Moreover, 7,12-dimethylbenz[a]anthracene (DMBA, 400 nmol per mouse) was applied to all the animals in the remaining four groups. After 1 week, different concentrations of venom (17.5 μg, 35 μg, and 52.5 μg per animal) were applied to each animal in the Groups III–V. Thirty minutes after the application of venom, croton oil was applied on the same position where venom was administered to the animals of Groups III–V. Animals in Group II were treated as the positive control (without venom) and received croton oil as in Groups III–V. The findings of this study revealed that venom extract of L. quinquestriatus inhibits DMBA + croton oil-induced mouse skin tumor incidence and tumor multiplicity. Venom treatment also decreased the expression of proinflammatory cytokines. Immunohistochemistry results showed a downregulation of the expression of molecular markers such as Ki-67, nuclear factor kappa-B, cyclooxygenase-2, B-cell lymphoma-2, and vascular endothelial growth factor, in venom-treated animals. Our findings suggest that the venom of L. quinquestriatus possesses in vivo anticancer potential and may be used in the development of anticancer molecules.

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Tannic acid mitigates the DMBA/croton oil-induced skin cancer progression in mice

Cited by 23 publications

References 55 publications

Tannic acid modulates NFκB signaling pathway and skin inflammation in NC/Nga mice through PPARγ expression

Tannic acid modulates NFκB signaling pathway and skin inflammation in NC/Nga mice through PPARγ expression

Tannic Acid: Specific Form of Tannins in Cancer Chemoprevention and Therapy-Old and New Applications

Investigation of in vivo potential of scorpion venom against skin tumorigenesis in mice via targeting markers associated with cancer development

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