Tannic acid induces dentin biomineralization by crosslinking and surface modification

Kong, Wei; Du, Qiaolin; Qu, Yinan; Shao, Changyu; Chen, Chaoqun; Sun, Jian; Mao, Caiyun; Tang, Ruikang; Xiao, Gu

doi:10.1039/d1ra07887a

Cited by 19 publications

(11 citation statements)

References 47 publications

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“…7 and 8). TS promoted biological apatite formation onto enamel, which could be attributed to the TA and SF released from the TS (Tian et al 2011; Kong et al 2022). TS@NaF-6/4 demonstrated significantly higher CaF 2 formation onto enamel compared with varnish, TS, and H 2 O.…”

Section: Discussionmentioning

confidence: 99%

Mussel-Inspired Hydrogels for Fluoride Delivery and Caries Prevention

Liang

Luo

et al. 2022

J Dent Res

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Fluoride agents hold promise for the repair and prevention of caries lesions, but their interaction with enamel is often hampered and diminished because of the dynamic wet environment in the oral cavity, which affects the efficacy of fluoride delivery and limits treatment success. We herein developed a mussel-inspired wet adhesive fluoride system (denoted TS@NaF) fabricated by the self-assembly of tannic acid (TA), silk fibroin (SF), and sodium fluoride (NaF). TS@NaF demonstrated remarkable biological stability and biocompatibility, showed reliable wet adhesion, released fluoride ions (F−) topically, and induced significant deposition of calcium fluoride (CaF2) onto enamel in vitro. Furthermore, TS@NaF provided an anticaries effect in vitro and induced a detectable increase in enamel mineral density. Advanced fluoride-releasing bioadhesives are therefore promising candidates for caries prevention and highlight the great potential of mussel-inspired dental materials in clinical applications.

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Section: Discussionmentioning

confidence: 99%

Mussel-Inspired Hydrogels for Fluoride Delivery and Caries Prevention

Liang

Luo

et al. 2022

J Dent Res

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“…Other factors, such as the collagen fibrils, play an essential role, and substances like tannic acid for crosslinking collagen fibrils also interact chemically with dentinal tissues to improve remineralisation. 19 , 20 Additionally, restorative materials, such as those releasing calcium hydroxide, can induce the formation of tertiary dentin. 21 , 22 …”

Section: Target Tissues and Aimsmentioning

confidence: 99%

Bioactivity of Dental Restorative Materials: FDI Policy Statement

Schmalz

Hickel

Price

et al. 2023

International Dental Journal

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“…To study the remineralization ability of dental materials, Fourier Transform Infrared Spectroscopy (FTIR), among other methods, can be used. This spectroscopic analysis method allows determining the nature of the mineral component of samples and provides quantitative information on the changes in mineral and matrix composition as mineralization takes place [ 13 , 14 ]. Energy Dispersive Spectroscopy (EDX), on the other hand, is used to analyze the chemical elements found on the surface of dentin once it has been treated with different remineralizing agents [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Remineralization Potential of Three Restorative Glass Ionomer Cements: An In Vitro Study

Ghilotti

Fernández

Sanz

et al. 2023

JCM

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The aim of this in vitro study was to evaluate the remineralizing ability of three glass ionomers on demineralized dentin with different thicknesses and time periods. Fifty third molars were obtained and were sectioned into 1-, 2-, and 3-mm thick slices (n = 36 for each thickness). The specimens were demineralized with 18% EDTA for 2 h. From the glass ionomer cements (GICs) under study (Ketac Molar Aplicap, Equia Forte, or Riva Light Cure), 1 mm was placed over each slice, set, and preserved in PBS until observation after 1, 7, 14, and 28 days after placement. For each material, thickness, and time, three samples were prepared. Using Fourier Transform Infrared Spectrometry (FTIR), apatite formation was determined on the side opposite to that on which the material had been placed. By means of Energy Dispersive Spectroscopy (EDX), the changes in the Calcium/Phosphate (Ca/P) ratio were evaluated. These changes were compared between the different materials by means of a two-way ANOVA test, considering time and dentin thickness, for a significance level of p < 0.05. Results: FTIR showed a peak at 1420 cm−1, evidencing the presence of carbonated hydroxyapatite in all the materials after 14 days, which indicates that a remineralization process occurred. Riva Light Cure showed the most homogeneous results at all depths at 28 days. The Ca/P ratio was maximum at 7 days in 2 mm of dentin for Riva Light Cure and Equia Forte HT (3.16 and 3.07; respectively) and for Ketac Molar at 14 days in 1 mm (3.67). All materials induced remineralization. Equia Forte achieved the greatest effect at 2 mm and Ketac Molar at 1 mm, whereas Riva Light Cure showed similar results at all depths. In terms of Ca/P ratio, Equia Forte and Riva Light Cure remineralized best at 2 mm, whereas for Ketac Molar, it was 1 mm. Carbonate apatite formation was higher at 24 h and 7 days for Ketac Molar, whereas it decreased at 14 days for Ketac Molar and peaked in Riva Light Cure and Equia Forte.

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Tannic acid induces dentin biomineralization by crosslinking and surface modification

Abstract: Tannic acid acts as a cross-linker to promote the biomineralization of dentin and adjusts the mineralization interface through the wetting effect.

Cited by 19 publications

References 47 publications

Mussel-Inspired Hydrogels for Fluoride Delivery and Caries Prevention

Mussel-Inspired Hydrogels for Fluoride Delivery and Caries Prevention

Bioactivity of Dental Restorative Materials: FDI Policy Statement

Remineralization Potential of Three Restorative Glass Ionomer Cements: An In Vitro Study

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