Tangeretin exerts anti-neuroinflammatory effects via NF-κB modulation in lipopolysaccharide-stimulated microglial cells

<i>Citrus</i> Flavonoids and Human Cancers

“…In addition, hesperidin and tangeretin extracted from tangerine peel (Citrus reticulatae pericarpium) were reported to have potent anti-neuroinflammatory capacity by suppressing LPS-induced proinflammatory NO, TNF-α, IL-1β and IL-6 secretion [56]. Moreover, tangeretin was reported to have markedly reduced LPS-stimulated phosphorylation of IκB-α and IKK-β, as well as the nuclear translocation of the p65 subunit of proinflammatory transcription factor NF-κβ [57]. Furthermore, auraptene (AUR) was reported to suppress the LPS-induced inflammation in the brain of model mice possibly through inhibiting the expression of (COX)-2 [58].…”

Stimulation effect of wide type CFTR chloride channel by the naturally occurring flavonoid tangeretin

“…Here, we found that a new flavonoid compound, tangeretin, as CFTR activator, further confirmed the role of flavonoids as leading compounds in activation of CFTR chloride channel activity. Tangeretin exists abundantly in Pericarpium Citri Reticulatae Viride and has been reported to have anti-neuroinflammatory [21], anti-tumor [22], antibacterial [23] and human basophil histamine release inhibition [24] activities. In the present study, we found that tangeretin could significantly activate CFTR chloride channel activity which added CFTR as a new molecular target to this compound.…”

Neuroinflammatory processes in cognitive disorders: Is there a role for flavonoids and n-3 polyunsaturated fatty acids in counteracting their detrimental effects?

“…(Suk et al, 2003;Yeh et al, 2014). In addition, orientin (10-40 µM; extracted from Trollius chinensis), tangeretin (80 µM; a flavonoid from citrus fruit peels) and quercetin (20-30 µM) all reduced LPS-induced NF-κB expression in BV-2 microglial cells (Kang et al, 2013;Shu et al, 2014;Zhou et al, 2014). Of particular interest, it has recently been demonstrated that EGCG (10 µM) attenuates LPS-induced inflammatory and oxidative stress responses by modulating Nrf2 and decreasing Snitrosylation levels of proteins involved in free radical scavenging such as superoxide dismutase (SOD) in BV-2 microglial cells (Qu et al, 2014).…”