<i>Citrus</i> Flavonoids and Human Cancers

Abstract

Nowadays cancers pose a great threat to the health of human beings. Based on studies on the flavonoids and other bioactive compounds of Citrus fruits in current literature, it was widely suggested that the consumption of Citrus fruits is beneficial to the prevention and treatment of human chronic diseases including cancers. In the past decades, the study concerning Citrus flavonoids has covered various areas including the type, content and distribution of flavonoids in fruits; their variation between wild and cultivated genotypes; their antioxidant, antiinflammation, anti-aging, antimicrobial and anticarcinogenic activities. To enlighten future Citrus germplasm study, this review introduces briefly the functions of main types of Citrus flavonoids, including antioxidant, antiinflammation and anti-aging activities, and their relationships to human cancers. Most importantly, the mechanisms of action by which Citrus flavonoids play their roles in human cancer prevention and treatment were summarized.

Peels of Lemon and Orange as Value-Added Ingredients: Chemical and Antioxidant Properties

“…Antioxidant capacity of food can use as an indicator of the beneficial effects on human health (Prior and Wu 2013). Antioxidants e.g., flavonoids, phenolic acids, vitamin C, vitamin E and tannins have different biological properties, such as anti-carcinogenic, antiatherosclerotic effects, reduce coronary diseases and contribute to the maintenance of the gut health by modulation of microbial balance and these properties improve the quality and value of food & anti-aging (Lucia et al, 2008;Kondo et al, 2002;Tuberoso et al, 2013;Liu 2004;Cai et al, 2004;Ke et al, 2015).…”

Phytochemistry and Pharmacology of Phyllanthus niruri L.: A Review

“…Kaempferol, quercetin and ellagic acid in P. niruri also act by downregulating different pathways. Kaempferol attenuates mitogen‐activated protein kinase signalling pathways that are mediated through ERK, c‐Jun N‐terminal kinase and p38 (Ke et al , ). Quercetin induces apoptosis via AMP‐activated protein kinase activation and p53.…”

Preparation and characterizations of new biomaterials by anthocyanins adsorption on hydroxyapatite-based materials

“…Antioxidant activity denotes the ability of a bioactive compound to maintain cell structure and function by effectively clearing free radicals, inhibiting lipid peroxidation reactions and preventing other oxidative damage [13]. It is also a foundation of many other biological functions, such as anti-cancers, antiinflammation and anti-aging [14,15]. On the other hand, the prevention of many chronic diseases, such as cancer, diabetes and cardiovascular disease, has been suggested to be associated with the antioxidant activity [16,17].…”