Tandem electrocatalytic aziridination – ring expansion of simple aromatic olefins using ammonia and carbon dioxide

Abstract

N-heterocycles are prominent structural motifs frequently occurring in organic synthesis and applications. Therefore, straightforward and green synthesis methods using common starting materials like alkenes are highly desired. Here, the metal-free...

Recent developments on microwave-assisted organic synthesis of nitrogen- and oxygen-containing preferred heterocyclic scaffolds

“…Nitrogen-containing heterocyclic motifs are abundant in natural products and natural product-derived drug molecules. 43,44 Therefore, chemical synthesis of these scaffolds has been of interest among organic synthesis and medicinal-chemistry research groups. Oxygen-containing molecules such as coumarins are also present in nature and display various biological functions.…”

A comparative overview of the electrochemical valorization and incorporation of CO2 in industrially relevant compounds

“…[24][25][26] Additionally, developing new materials and chemicals that have a lower carbon footprint, as well as recycling and reusing materials to reduce waste and emissions are important aspects towards closing the carbon loop. [27][28][29][30][31] A most viable strategy for CO 2 valorization is to use it as a building block towards value-added chemicals, [32][33][34][35][36] fuels 37,38 and construction materials. 39,40 This way, a sustainable source of chemicals and materials is provided by introducing generated CO 2 back in the production processes as an elementary building block, gradually transforming the typical linear production chain to a more sustainable production loop.…”

Electrochemical intramolecular N(sp2)–H/N(sp3)–H coupling for the synthesis of 1H-indazoles

“…13 In addition, commercially available NH 3 serving as a kind of the most attractive nitrogen donor has rarely been applied in organic transformations. 14,15,19 In particular, in 2017, Xu's group first realized the electrochemical synthesis of phenanthridines by employing molecular NH 3 as the nitrogen donor, in which anodic oxidation of the in situ generated aryl imine by condensation of biaryl aldehydes and NH 3 facilitated the subsequent radical C–H/N–H cyclization process. 15 a In fact, Stahl et al recently disclosed three complementary methods to furnish electrochemical N–N coupling of ketone imines and made a deep investigation into the reaction process, including the phosphate base-promoted proton-coupled electron-transfer (PCET) process, the molecular iodine-mediated N–H/N–H coupling reaction via N–I formation and the Cu-catalysed radical N–N coupling reaction.…”