Recent developments on microwave-assisted organic synthesis of nitrogen- and oxygen-containing preferred heterocyclic scaffolds

Abstract

This review highlights recent developments in the microwave-assisted organic synthesis of N- and O-containing heterocycles with specific examples of pyrazolopyrimidines-, coumarin-, quinoline-, and isatin-based scaffolds and their associated biological activities.

Unveiling the Untapped Potential of Bertagnini’s Salts in Microwave-Assisted Synthesis of Quinazolinones

“…This technology's significance lies in its ability to accelerate reaction times and improve yields, enhance levels of selectivity, and synthesize complex molecules with unprecedented ease [38,39]. Adopting microwave-assisted techniques for synthesizing nitrogen-and oxygen-containing frameworks has become a cornerstone strategy in organic chemistry [40][41][42][43][44][45], offering unparalleled advantages in reaction efficiency [46] and sustainability [47]. Microwave irradiation facilitates the rapid and uniform heating of reaction mixtures, leading to accelerated reaction rates and higher yields than conventional heating methods [48].…”

Recent advances in microwave-assisted multicomponent synthesis of spiro heterocycles

“…In particular, microwave-assisted synthesis also shows great promise for the rapid and selective synthesis of spiro heterocycles, as demonstrated by several recent studies. [24][25][26][27][28][29][30][31][32][33][34] Due to their diverse biological activities and pharmaceutical relevance, spiro heterocycles have received considerable attention in recent years. Because of their diverse structural features, unique properties, and wide range of applications, spiro heterocycles are a fascinating class of organic compounds.…”

Microwave‐Assisted Synthesis of Fluorinated 5‐Membered Nitrogen Heterocycles

“…[44] There are several books, journal reviews, and monographs dedicated to MW-assisted synthesis [45][46][47][48][49][50] giving in-depth coverage of the subject matter. There have recently been a few reviews published in the literature on the use of microwaves in the synthesis of N-heterocyclic compounds; [51][52][53][54][55] however, there is a lack of publications on the use of microwaves in the synthesis of fluorinated 5-membered N-heterocycles. This article highlights the microwave-assisted fluorination of 5-membered N-heterocyclic compounds along with the synthesis of fluorinated 5-membered N-heterocyclic compounds using fluorinated starting materials.…”