Tamoxifen Effects on the lipid profile in premenopausal women with Breast cancer: A follow up study

Abstract

Background: Breast cancer composed of several biologic subtypes that have response to hormonal therapy. Tamoxifen is hormonal therapy with tissue-pecific antagonistic or agonist effects, the latter being responsible for multiple effects on lipid metabolism in women. Objective: This study was designed to determine the impact of Tamoxifen on the serum lipid profile in breast cancer women. Patients and methods: Prospective observation cohort study conducted at Oncology Teaching Hospital, Medical city complx.starting from October 2015 to October 2016. A total number of 40 premenopausal women with breast cancer were enrolled in this study according to inclusion criteria. Patients were followed for three months by the measurements TC, TG, HDLcholesterol and BMI. Results: At the end of third months of hormonal therapy, Tamoxifen showed a significant decrease in TG, VLDL (p< 0.001 for both). On the other side HDL and BMI showed significant increase over three months duration , (p = 0.001 and 0.006, respectively). Conclusion: Beneficial alterations of lipid profiles were seen in pre-menopausal breast cancer patients treated with Tamoxifen.