Tamilial Occurrence of Congenital Hypertrophic Pyloric Stenosis

Cameron, Angus L.

doi:10.1001/archsurg.1955.01270120085011

AMA Arch Surg

1955

DOI: 10.1001/archsurg.1955.01270120085011

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Tamilial Occurrence of Congenital Hypertrophic Pyloric Stenosis

Angus L. Cameron¹

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1955

1981

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Cited by 8 publications

(2 citation statements)

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“…For each family, recurrence risk is given for an individual of unknown sex, together with the risks when sex is male or female respectively. Sources-1:Gailey (1948), as reported inCameron (1955); 2: Carter and Evans (1969), family No. 352; 3: Carter and Evans (1969), family No.…”

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confidence: 99%

Recurrence risks in complex inheritance with special regard to pyloric stenosis.

Lalouel¹,

Morton²,

Maclean³

et al. 1977

Journal of Medical Genetics

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SUMMARY A large body of data on segregating families is used to generate specific recurrence risks conditional on sex and birth order for the best-fitting model of polygenes plus maternal effect. The method is general for diseases of complex inheritance, and lies within the competence of any serious genetic clinic. The question of whether consultees demand as much specificity should be subordinate to the question of whether counsellors are justified in providing less.Genetic counselling is a transaction which includes specification of a recurrence risk for a particular disease in a particular family, using parameters from segregation analysis of a larger body of data. This problem has been solved for simple cases (Murphy and Mutalik, 1969), and the utility of computer programmes to determine specific risks has been *demonstrated (Heuch and Li, 1972). It remains to generalise these prototypes to more complex pedi-*grees and modes ofinheritance.As a first step we here apply the mixed model of Morton and MacLean (1974) to a large body of data on pyloric stenosis, a disease of obscure and presumably complex aetiology whose incidence varies widely with sex, birth order, and ethnic group. The mixed model subsumes polygenes, major loci, and common environment. Application of the mixed model illustrates the power and specificity which complex segregation analysis brings to prediction of recurrence risks. Pyloric stenosisDiagnosis of a hypertrophic muscular tumour of the pylorus presents several problems. The tumour may be present without causing symptoms at any time (Carter and Powell, 1954). Distinction from pylorospasm is not clear.

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confidence: 99%

Recurrence risks in complex inheritance with special regard to pyloric stenosis.

Lalouel¹,

Morton²,

Maclean³

et al. 1977

Journal of Medical Genetics

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“…[1][2][3][4] Up to a generation ago, the risk among siblings of affected children could be estimated, but not among their offspring, because of high infant mortality from the disease. [1][2][3][4] Up to a generation ago, the risk among siblings of affected children could be estimated, but not among their offspring, because of high infant mortality from the disease.…”

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confidence: 99%

Infantile Hypertrophic Pyloric Stenosis In Four Siblings

Burmeister¹,

Hamilton²

1964

Arch Pediatr Adolesc Med

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Adult Hypertrophic Pyloric Stenosis

Mack¹

1959

AMA Arch Intern Med

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Tamilial Occurrence of Congenital Hypertrophic Pyloric Stenosis

Cited by 8 publications

References 37 publications

Recurrence risks in complex inheritance with special regard to pyloric stenosis.

Recurrence risks in complex inheritance with special regard to pyloric stenosis.

Infantile Hypertrophic Pyloric Stenosis In Four Siblings

Adult Hypertrophic Pyloric Stenosis

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