Talassemias alfa

Cançado, Rodolfo Delfini

doi:10.1590/s1516-84842006000200005

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…That is why the correct diagnosis requires search for mutations in the alpha globin genes by molecular biology methods (11) . The prevalence of silent carriers in the Brazilian population is estimated to be 10%-20%; the prevalence of the alpha thalassemia trait, 1%-3%, with the one-gene deletion (-α 3.7 ) being the most commonly reported (12) . Another common mutation is the 4.2 Kb deletion (-α 4.2 ) (13,14) .…”

Section: Introductionmentioning

confidence: 99%

RDW as differential parameter between microcytic anemias in “pure” and concomitant forms

Matos¹,

Borges²,

Fernandes³

et al. 2015

Jornal Brasileiro De Patologia E Medicina Laboratorial

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Introduction: Iron deficiency anemia and thalassemia minor are microcytic and hypochromic types of anemia commonly found in our environment. The correct differentiation between them is of great clinical importance, although it is often hampered by the coexistence of diseases that may alter the results of standard tests for their discrimination, in addition to the significant costs of such tests. Objective:The objective of this study was to investigate the discriminatory power of red cell distribution width (RDW) between iron deficiency anemia and thalassemia minor. Method: Blood parameters were compared in 227 patients with iron deficiency anemia and/or thalassemia minor after diagnosis confirmed by molecular biology and HbA2 measurement for alpha thalassemia and beta thalassemia trait respectively. The frequency of alpha thalassemia trait in a population from two public hospitals of Minas Gerais was also determined. Result and conclusion: RDW was able to differentiate iron deficiency anemia from thalassemia trait, what indicates that this blood count parameter is a useful tool since concomitant disorders are excluded. In addition, a high frequency of the -α 3.7 mutation was observed in the study population (20.3%), justifying its investigation when another cause for microcytic anemia is absent.

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Section: Introductionmentioning

confidence: 99%

RDW as differential parameter between microcytic anemias in “pure” and concomitant forms

Matos¹,

Borges²,

Fernandes³

et al. 2015

Jornal Brasileiro De Patologia E Medicina Laboratorial

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“…Outra questão preocupante é em relação ao número de gestantes anêmicas e com história prévia de anemia -13% (n=10) -ressaltando-se que essa carência pode ser relacionada com a alimentação pobre em ferro consumida por essas mulheres antes mesmo da gestação, e também devido a fatores genéticos, como o traço talassêmico, que segundo Cançado (2006), pode ser denominado de portador silencioso, e resulta em uma forma de talassemia praticamente assintomática e com alterações laboratoriais mínimas ou ausentes, o que dificulta o seu diagnóstico por técnicas laboratoriais convencionais. Diante deste caso, é notório que a prevenção das anemias hereditárias deva começar o mais precocemente possível e ser feita por meio de ações educadoras, de um diagnóstico laboratorial realizado por profissionais capacitados e por estudo familiar (SAKAMOTO et al, 2008).…”

Section: Discussionunclassified

Prevalência De Anemia E Seus Fatores Determinantes Em Gestantes De Município Do Estado Do Rs

Frick

Frizzo

2018

Rev. Cont. Saúde

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A anemia afeta em todo mundo aproximadamente dois bilhões de pessoas, sendo as gestantes e crianças alguns dos grupos de populações mais acometidos. Este estudo propõe determinar a prevalência de anemia e seus fatores determinantes em gestantes. Foram analisados os dados de Hemoglobina (Hb), Hematócrito (Ht) e Volume Corpuscular Médio (VCM) de 107 gestantes, sendo que apenas 77 delas foram entrevistadas, para definir as características e os fatores determinantes no desenvolvimento de anemia. Encontrou-se 15 (14,02%) gestantes com Hb inferior a 11g/dL, dentre elas, 3 (2,83%) com Ht inferior a 33%. Ainda, 15 (14,02%) gestantes possuíam VCM inferiores a 80 fL. Dentre as gestantes entrevistadas, 12 (15,58%) apresentaram anemia, destas 8 (66,67%) possuíam renda inferior a dois salários mínimos, 9 (75%) relataram ter como grau de instrução o ensino fundamental e 3 (25%) consumiam poucos alimentos contendo ferro e não utilizavam sulfato ferroso como suplementação. Esses resultados mostram um grupo carente, e com fatores determinantes que aumentam a probabilidade de desenvolver anemia na gestante e no feto, necessitando, portanto, de medidas que possibilitem identificar, prevenir, orientar essas gestantes.

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“…Nonetheless, from a worldwide perspective (and besides iron deficiency), the alpha-or beta-thalassemia traits should be considered as a common cause of low Hb, MCV, and HCM values among apparently healthy people [24]. Among Brazilians, thalassemia trait is a possible cause of a considerable proportion of mild microcytic-hypochromic anemia cases, most of which may be mistreated with iron supplementation in the clinical setting (if the nutritional iron deficiency is not a coincident complicating factor) [34][35][36].…”

Section: Discussionmentioning

confidence: 99%

Anemia among pregnant women attending primary healthcare units in the municipality of São Paulo, Brazil: evaluations after the mandatory fortification of wheat and maize flours with iron

Machado¹,

Carli²,

Szarfarc³

et al. 2016

Nutrire

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Background: Improvements in the iron status of a population as result of food fortification are expected at the long term. In Brazil, the effectiveness of mandatory flour fortification with iron has been evidenced mostly from surveys on gestational anemia after 1 or 2 years from its implementation, in 2004. Our aim was to assess hemoglobin (Hb) concentrations and the prevalences of anemia and linked erythrocyte morphology patterns among pregnant women in 2006 and 2008. Methods: The study design was retrospective and cross-sectional. The analysis was based on secondary data in 546 medical records from women at the times of their first prenatal attendance in 13 public primary healthcare units of the Butantan Administrative Region from São Paulo (SP), Brazil. Anemia was evaluated from Hb concentration (cut-off <11.0 g/dL) and erythrocyte morphology patterns from mean corpuscular volume (MCV), mean corpuscular Hb concentration (MHC), and red cell distribution widths (RDW). Recorded sociodemographic and obstetric data included maternal age, gestational age, ethnoracial self-classification, and residence type. Student's t tests, analysis of variance, Chi-squared tests, and multiple linear and logistic regressions were employed in the statistical analysis using a significance level of 5 %. Results: The prevalence of anemia was 9.7 % in 2006 and 9.4 % in 2008 (P = 0.922), with no significant difference in mean Hb concentrations (P = 0.159). Normocytosis (normal MVC), normochromia (normal MHC), and anisocytosis (high RDW) were found in most anemia cases, suggesting that the low Hb concentrations resulted from mixed causes. In multiple regression analysis, gestational age at the first prenatal attendance was an independent predictor of low Hb and of having anemia. Moreover, black ethnoracial self-classification was associated with lower Hb.

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Talassemias alfa

Cited by 6 publications

References 6 publications

RDW as differential parameter between microcytic anemias in “pure” and concomitant forms

RDW as differential parameter between microcytic anemias in “pure” and concomitant forms

Prevalência De Anemia E Seus Fatores Determinantes Em Gestantes De Município Do Estado Do Rs

Anemia among pregnant women attending primary healthcare units in the municipality of São Paulo, Brazil: evaluations after the mandatory fortification of wheat and maize flours with iron

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