Talaromycosis (Penicilliosis) Due to Talaromyces (Penicillium) marneffei: Insights into the Clinical Trends of a Major Fungal Disease 60 Years After the Discovery of the Pathogen

Cao, Cunwei; Xi, Liyan; Chaturvedi, Sudha

doi:10.1007/s11046-019-00410-2

Cited by 110 publications

(142 citation statements)

References 104 publications

Supporting

Mentioning

130

Contrasting

Unclassified

Order By: Relevance

“…Infections with Talaromyces marneffei are geographically restricted to southeast Asia and are seen predominantly in people living with HIV [ 27 ]. Six decades ago, Penicillium marneffei was described as a novel pathogen, but since several years it is grouped as the sole pathogenic and dimorphic species within the genus Talaromyces [ 28 , 29 ].…”

mentioning

confidence: 99%

“…Six decades ago, Penicillium marneffei was described as a novel pathogen, but since several years it is grouped as the sole pathogenic and dimorphic species within the genus Talaromyces [ 28 , 29 ]. The history of T. marneffei was recently extensively reviewed [ 27 ], but it deserves attention in this special issue as Sethuraman and co-workers reported five apparent autochthonous cases among patients with different underlying disorders that lived outside the endemic region [ 30 ]. This highlights that the current map of endemic mycoses needs to be redrawn, not only for T. marneffei but also for Blastomyces , Coccidioides , Histoplasma , and Paracoccidioides as their incidence and geographic range has changed [ 31 ].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Detection and Control of Fungal Outbreaks

et al. 2020

View full text Add to dashboard Cite

mentioning

confidence: 99%

mentioning

confidence: 99%

Detection and Control of Fungal Outbreaks

et al. 2020

View full text Add to dashboard Cite

“…We chose voriconazole for the treatment because the literature review showed it is an effective and convenient drug for intravenous and oral sequential therapy. 15 Later treatment process confirmed that our treatment options are effective and feasible. Bone destruction, subcutaneous mass and lung changes were completely absorbed in the third month after discharge.…”

Section: Discussionmentioning

confidence: 66%

A Talaromyces marneffei infection with osteolytic lesions in an HIV-negative patient at non-endemic areas: A case report

Youfei

2020

SAGE Open Medical Case Reports

View full text Add to dashboard Cite

Talaromyces marneffei infection is an endemic opportunistic infection for immunodepression patients, especially HIV-positive patients. Our case describes an unendemic and HIV-negative patient who presented with fever, subcutaneous mass, osteolytic destruction of the skull and subcutaneous abscess penetrating the diseased skull. The growth of Talaromyces marneffei was identified by the culture of the frontal pus, sputum, blood and bone marrow. Due to severe nausea and vomiting during the use of amphotericin B, voriconazole was finally selected for treatment. Two weeks after intravenous infusion of voriconazole injection, the patient was given oral voriconazole tablets for 5 months. After the initial intravenous treatment of voriconazole, the patient developed increased dyspnea and required ventilator support with endotracheal intubation, and methylprednisolone was given intravenously for 5 days. All lesions absorbed and no obvious discomfort was found during the follow-up at the third month after discharge. At present, the patient has been followed up for more than 3 years without recurrence. The case aims to raise doctors’ awareness of this rare disease in non-endemic areas and HIV-negative patients.

show abstract

“…1 This disease rarely occurs in healthy person, and it is more common in immunocompromised person. 2 People who have not HIV infection and underlying disease with talaromycosis are rare in clinic. 3 At present, methamphetamine has become the second-most widely abused drug class after cannabis, and it has become a serious public health problem, with an estimated 24 million users worldwide.…”

Section: Introductionmentioning

confidence: 99%

Drug-related talaromycosis: A case report

Shi

2020

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

Talaromycosis is a rare deep fungal infection caused by Talaromyces marneffei. Currently, methamphetamine has become the second-largest drug abuse category in the world after cannabis and has become a serious public health problem. Methamphetamine can inhibit human immune system and increase the probability of pathogenic microorganism infection. On 8 October 2016, a 20-year-old man with a fever history of 2 months was admitted to our hospital. He had bloody stools and abdominal pain during hospitalization. There was no significant abnormality in physical examination. Because of the misdiagnosis, he underwent improper treatment. Periodic acid-Schiff stain (PAS) staining showed that the mucosa of distal ileum, ascending colon, transverse colon, and sigmoid colon were infiltrated by a large number of tissue cells, which contained a large number of blue purple particles. In addition, a large number of histiocytes and multinucleated giant cells can be seen in the lamina propria of ileum mucosa, and fungal spores can be seen in histiocytes. Finally, he was diagnosed as talaromycosis and took itraconazole 0.2 g twice a day. After 5 days, the temperature dropped to normal and the inflammation disappeared, and he continued to take itraconazole for 6 months. Due to the neglect of the history of drug abuse and the concealment, drug-related talaromycosis is often misdiagnosed. Pathological examination is warranted for diagnosis talaromycosis. This condition requires a long-term anti-fungal therapy.

show abstract

Talaromycosis (Penicilliosis) Due to Talaromyces (Penicillium) marneffei: Insights into the Clinical Trends of a Major Fungal Disease 60 Years After the Discovery of the Pathogen

Cited by 110 publications

References 104 publications

Detection and Control of Fungal Outbreaks

Detection and Control of Fungal Outbreaks

A Talaromyces marneffei infection with osteolytic lesions in an HIV-negative patient at non-endemic areas: A case report

Drug-related talaromycosis: A case report

Contact Info

Product

Resources

About