Takotsubo-shaped cardiomyopathy with type I CD36 deficiency

Abstract

A transient left ventricular apical ballooning (so-called "ampulla" or "Takotsubo-shaped" cardiomyopathy) with type I CD36 deficiency is described in a 71-year-old woman. The patient was referred because of chest pain and worsening of dyspnea. Electrocardiogram showed T-wave inversions on the precordal leads, and acute coronary syndrome was suspected. Left ventricular apical ballooning was observed by echocardiogram and left ventriculography, and coronary arteriography did not reveal any significant stenosis. Left ventricular motion normalized at the follow-up period and there were no increases in specific markers for myocardial damage, such as myocardial band fraction of creatine kinase and troponin T, through out the admission. 123I-metaiodobengylguanidine myocardial single photon emission computed tomography (SPECT) revealed decreased accumulation areas at the apex, while 201Tl SPECT showed normal accumulation. An abnormal metabolism of cardiac free fatty acid was suggested by lack of accumulation of 123I beta-methyliodophenyl pentadecanoic acid (BMIPP) SPECT. No CD36 expression in either platelets or monocytes/macrophages was shown using flow cytometer analysis and type I CD36 deficiency was diagnosed. DNA sequencing showed that the patient had compound heterozygosity of the CD36 gene (a nucleotide change in C478T and an adenine insertion at nucleotide 1159 in exon 10). Although CD36 deficiency is thought to be involved with many cardiovascular disease and metabolic abnormalities, Takotsubo-shaped cardiomyopathy with CD36 deficiency had not been reported. Further studies of Takotsubo-shaped cardiomyopathy and CD36 deficiency may reveal an association between this cardiomyopathy and specific genetic profiles.

Recurrent Stress-Induced Cardiomyopathy: A Case Report and Review Article

“…One may speculate a genetic predisposition towards developing such a recurrent syndrome. Japanese investigators have detected CD36 deficiency in patients who developed ABS, suggesting that certain genetic profiles are more susceptible [15]. …”

Recurrence of Stress-Induced (Takotsubo) Cardiomyopathy

“…In cases of recurrence, one may cautiously speculate that perhaps there is a genetic predisposition towards developing such a reversible syndrome. Of note, Japanese investigators have detected CD 36 deficiency in a patient who developed stress-induced cardiomyopathy, suggesting that certain genetic profiles may be more susceptible [15]. …”

Can takotsubo cardiomyopathy be familial?

“…A review of literature notes the recent observation by Japanese investigators of CD 36 deficiency in a patient with stress-induced cardiomyopathy; suggesting an association between this entity and certain genetic profiles [4]. The older patient we described had two episodes with features that satisfy proposed current diagnostic criteria for takotsubo cardiomyopathy [5].…”