Can takotsubo cardiomyopathy be familial?

Cherian, John; Angelis, Dimitrios; Filiberti, Allen; Saperia, Gordon M.

doi:10.1016/j.ijcard.2006.08.018

Cited by 32 publications

(27 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…16 Both emotional stress and physical stress cause recurrent ampulla cardiomyopathy and the time-to-recurrence ranges from 3 months to 13 years after initial presentation. 2,8,17,18 In the present cases, typical ampulla cardiomyopathy was documented at the initial admission and atypical ampulla cardiomyopathy, indicated by transient basal midventricular ballooning, was documented at the second admission. We thought that these 2 cases were very rare because of the unique feature of the recurrence.…”

Section: Discussionsupporting

confidence: 51%

Morphologically Unique Feature of Recurrent Ampulla (Takotsubo) Cardiomyopathy

Ikeda

Hisamatsu

Kijima

et al. 2009

Circ J

View full text Add to dashboard Cite

mpulla (takotsubo) cardiomyopathy is a novel heart syndrome characterized by transient left ventricular (LV) dysfunction, mimicking acute myocardial infarction. 1,2 Guidelines for the diagnosis of ampulla cardiomyopathy were recently established in Japan. 3 We report 2 rare cases of recurrent ampulla cardiomyopathy. Both patients experienced typical ampulla cardiomyopathy at the initial admission and atypical ampulla cardiomyopathy at the second admission. We diagnosed the transient LV apical ballooning as typical ampulla cardiomyopathy and the other types of transient LV ballooning as atypical ampulla cardiomyopathy in accordance with the guidelines. Case Reports Case 1A 55-year-old woman with a history of rhabdomyolysis was admitted to the Department of Internal Medicine because of severe general fatigue, vomiting and weakness of the extremities related to recurrent rhabdomyolysis. She did not have chest oppression or dyspnea at the initial admission. At that time, her pulse rate was 127 beats/min, blood pressure 130/79 mmHg, and temperature 36.4°C. The leukocyte count was elevated at 11,800/ μl. The serum levels of aspartate aminotransferase (AST) (208 IU/L), lactate dehydrogenase (LDH) (840 IU/L), creatine kinase (CK) (7,972 IU/L), CK-MB (68 IU/L) and C-reactive protein (CRP) (6.2 mg/dl) were also elevated. Electrocardiogram (ECG) revealed sinus rhythm and T-wave inversion in leads II, III, aVF and V3-6 with prolongation of the QT interval (QTc 0.52 ms) (Fig 1B). Transthoracic echocardiography on admission revealed akinesis of the left ventricle, except in the basal region (ejection fraction 41%) (Fig 2A). She recovered 4 weeks later and was discharged because her general condition had improved with treatment for rhabdomyolysis and repeat echocardiography showed normalization of LV wall motion. The T wave inversion and the QT interval also normalized before discharge.One month later, she again experienced general fatigue, vomiting, weakness of the extremities again because of recurrent rhabdomyolysis, but she also had chest oppression and dyspnea. The leukocyte count was elevated (21,600/ μl), as were the serum levels of AST (166 IU/L), LDH (709 IU/L), CK (2,713 IU/L), CK-MB (108 IU/L), CRP (5.9 mg/dl) and noradrenalin (NA) (1,492 pg/ml). ECG on admission revealed sinus rhythm and T-wave inversion in leads V1-3 with prolongation of the QT interval (QTc 0.50 ms) (Fig 1C). Transthoracic echocardiography on admission revealed a hypercontractile LV apex with an akinetic basal-to mid-LV (ejection fraction 43%) (Fig 2B). Urgent coronary angiography (CAG) did not reveal a significant stenotic lesion. Computed tomography of the abdomen and iodine-131-metaiodobenzylguanidine (MIBG) scintigraphy did not show pheochromocytoma. Her acute heart failure was medically treated, she recovered and was discharged. Case 2A 75-year-old man with a history of bronchial asthma was admitted to a nearby hospital because of worsening cough and dyspnea. He was treated with intravenous the- (Received December 2, 2007; revised manuscript...

show abstract

Section: Discussionsupporting

confidence: 51%

Morphologically Unique Feature of Recurrent Ampulla (Takotsubo) Cardiomyopathy

Ikeda

Hisamatsu

Kijima

et al. 2009

Circ J

View full text Add to dashboard Cite

show abstract

“…It is characterized by the finding of transient left ventricular wall motion abnormalities typically accompanied by chest pain, dynamic reversible ST-T segment abnormalities, and mild elevation of cardiac enzymes without significant coronary artery stenosis, which generally return normal within a few weeks. The majority of patients present with a recent history of emotional or physical stress [1][2][3][4].…”

Section: Discussionmentioning

confidence: 99%

“…Microvascular dysfunction in the absence of obstructive disease was demonstrated by invasive [1] and non-invasive [5] methods. Recent reports addressing TC in relatives [2] suggesting a possible genetic component to its etiology.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Broken heart syndrome in a 17-year-old girl

et al. 2009

View full text Add to dashboard Cite

Broken heart syndrome is characterized by transient left ventricular dysfunction with chest pain, electrocardiographic changes, and release of myocardial enzymes mimicking acute myocardial infarction. Physical and emotional stress usually precede the onset of symptoms. This dysfunction, known as takotsubo cardiomyopathy (TC), has been observed predominantly in women older than 60 years of age but very rarely reported in younger adults or children. Here we describe a 17-year-old girl with TC.

show abstract

“…Kushiro and colleagues reported CD36 deficiency in a patient with stress-induced cardiomyopathy (13), suggesting an association between this entity and certain genetic profiles. This observation has led to the speculation that TTC might have a genetic component as described in a report by Cherian and colleagues (14). …”

Section: Epidemiologymentioning

confidence: 97%