Takotsubo cardiomyopathy

Matta, Anthony; Delmas, Clément; Campelo-Parada, Francesco; Lhermusier, Thibault; Bouisset, Frédéric; Elbaz, Meyer; Nader, Vanessa; Blanco, Stéphane; Roncalli, Jérôme; Carrié, Didier

doi:10.31083/j.rcm2301038

Cited by 19 publications

(15 citation statements)

References 98 publications

(127 reference statements)

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“…Takotsubo cardiomyopathy, also known as "broken heart syndrome", or TTS, was first described by Hikaru Sato in 1990, and it is a stress-induced cardiomyopathy (apical ballooning syndrome), that is, a clinical condition characterized by a transient dysfunction of left ventricular wall motion, provoking the development of acute reversible heart failure (HF). TTS is not associated with an occlusion of coronary vessels [4].…”

Section: Introductionmentioning

confidence: 82%

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The relevance of Takotsubo cardiomyopathy as a stress-induced disease

Ganych¹,

Oflidi²,

Zaitseva³

et al. 2023

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Takotsubo cardiomyopathy, or Takotsubo syndrome, can be quite rare found, but however the frequency of diagnosing with this disease among patients of cardiology departments is constantly growing. On the one hand, this may be due to improved diagnostics of this pathology, and on the other hand, to an increasing frequency of mental disorders in the human population and the spread of other risk factors, including drug-induced variants. The pathogenesis of the development of Takotsubo cardiomyopathy is associated with an increase in the level of catecholamines, which may be the result of a reactive sympathetic enhancement in response to external factors or be the result of taking antidepressants that can produce a similar effect. Although the diagnostics of this pathology has made significant progress, but however there is still no consensus on the strategy of treatment. This is due to the lack of large-scale randomized prospective studies that could justify one or another therapeutic approach. Basically, the efforts of medical doctors are aimed at maintaining cardiac activity, eliminating the trigger of the disease and at treating complications. The purpose of this review was to summarize the accumulated information related to the problems of etiology, pathogenesis, diagnosis and treatment of Takotsubo cardiomyopathy with an emphasis on the variants associated with the use of antidepressants.

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Section: Introductionmentioning

confidence: 82%

“…TTS is divided into 4 types: apical, basal, midventricular and focal TTS types [4]. In a clinical study using magnetic resonance imaging, 4 different types of regional ventricular ballooning were distinguished: apical (82%), biventricular (34%), median (17%) and basal (1%) variants.…”

Section: Clinical Manifestations and Classificationmentioning

confidence: 99%

The relevance of Takotsubo cardiomyopathy as a stress-induced disease

Ganych¹,

Oflidi²,

Zaitseva³

et al. 2023

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“…[19] [7] Antagoniści aldosteronu mogą mieć dodatkowe korzyści z działania kardioprotekcyjnego u pacjentów z TTS, biorąc pod uwagę synergistyczne działanie aldosteronu i katecholamin na układ sercowo-naczyniowy. [17] Wstrząs kardiogenny jest ważnym i zagrażającym życiu powikłaniem TTS. Pacjentów z tym powikłaniem możemy podzielić na dwie główne kategorie: z niedrożnością drogi odpływu lewej komory (LVOTO-Left ventricular outlet tract obstruction) oraz bez przeszkód w drodze odpływu lewej komory.…”

Section: Leczenieunclassified

“…Do niekorzystnych predyktorów należą także migotanie przedsionków, obecność stresorów fizycznych, wydłużony odstęp Qt, obniżona frakcja wyrzutowa lewej komory poniżej 35% oraz ostre powikłania, takie jak wstrząs kardiogenny czy zwężenie drogi odpływu lewej komory. [17]…”

Section: Rokowanieunclassified

Takotsubo cardiomyopathy – review of current literature

JAROSZ

GRUDZIŃSKA

DUDZIŃSKA

et al. 2022

J Educ Health Sport

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Takotsubo syndrome (TTS) also known as broken heart syndrome is acute cardiac disease, which is characterized by reversible ventricular motion abnormalities, in the absence of justifying coronary artery disease. The clinical entity was first described in Japan in 1991. The word “Takotsubo” is a container used by the Japanese to catch octopus, which has a narrow neck and a relatively wide base, which resembles the heart's shape in TTS. The cardiomiopathy predominantly affects postmenopausal women and is often preceded by emotional (death of close family member, domestic abuse) or physical (external injury, severe pain) stress. The exact pathophysiological mechanism has not yet been fully clarified. Inordinate amount of catecholamines released into bloodstream after stress attack plays a crucial role in the pathogenesis of TTS. Symptoms of Takotsubo cardiomyopathy such as chest pain and dyspnea are similar to acute myocardial infarction due to it TTS requires careful diagnosis. The main tools for making diagnosis are echocardiography, coronary angiography, ECG, cardiac biomarkers and cardiac magnetic resonance. The syndrome is usually reversible, nevertheless number of patients may develop complications such as cardiogenic shock, arrhythmias, heart failure. Treatment is mostly supportive including Angiotensin-converting enzyme (ACEi) inhibitors and angiotensin receptor blockers (ARBs), which may reduce the likelihood of recurrent episodes. Generally patients with TSS have favourable prognosis, although some deaths are reported. This article is a review of current medical knowledge about Takotsubo syndrome based on available publications in Pubmed and Google Scholar databases.

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“…This syndrome is commonly preceded by prolonged physical or emotional stress and is most prevalent in post-menopausal women [ 2 ]. Clinically, TTC patients often present with chest pain, dyspnea, and in severe cases, cardiogenic shock [ 3 , 4 ]. Up to 96% of patients with TTC will make a full recovery within several months of presentation [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

A Case Report and 31-Case Study: Does Takotsubo Cardiomyopathy in Myasthenia Gravis Patients Have a High Mortality Rate?

Gayfield¹,

Busken²,

Mansur³

2022

Cureus

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Myasthenia gravis is an autoimmune disorder in which antibodies are formed against post-synaptic nicotinic acetylcholine receptors that lead to impeded muscle contraction and commonly affects the oculomotor muscles. Takotsubo cardiomyopathy (TTC) is a dilated cardiomyopathy that can mimic a myocardial infarction and causes reversible systolic dysfunction. This is a case of a 66-year-old Caucasian male with a known history of ocular myasthenia gravis that presented to the emergency room with worsening dyspnea secondary to a myasthenic crisis. One day, following admission, his shortness of breath failed to improve and was found to meet the diagnostic criteria for takotsubo cardiomyopathy. A brief review of 31 previous cases summarizes the current case reports, patterns, and mortality associated with the myasthenic crisis associated with TTC.

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Takotsubo cardiomyopathy

Cited by 19 publications

References 98 publications

The relevance of Takotsubo cardiomyopathy as a stress-induced disease

The relevance of Takotsubo cardiomyopathy as a stress-induced disease

Takotsubo cardiomyopathy – review of current literature

A Case Report and 31-Case Study: Does Takotsubo Cardiomyopathy in Myasthenia Gravis Patients Have a High Mortality Rate?

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