Takayasu Arteritis and Spondyloarthritis: Coincidence or Association? A Study of 14 Cases

Rivière, Élodie; Arnaud, Laurent; Ebbo, Mikaël; Allanore, Yannick; Claudepierre, Pascal; Dernis, Emmanuelle; Ziza, Jean-Marc; Miceli‐Richard, Corinne; Philippe, P.; Richez, Christophe; Soubrier, Martin; Belkhir, Rakiba; Seror, R.; Mariette, Xavier; Pavy, Stéphan

doi:10.3899/jrheum.160762

Cited by 19 publications

(12 citation statements)

References 14 publications

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“…In the present case, the patient experienced low back pain when he was relatively young (in his 20s); however, the onset of AS preceded that of TA, and the fact that HLA-B27 was not detected is partially consistent with the characteristics reported by Rivière et al. 19 Furthermore, in patients who develop TA during the course of AS, a sudden increase in the CRP level is observed; the present case also proceeded in a similar manner. In a study focused on serum cytokine levels, the IL-23 level was higher in patients with AS than in healthy individuals.…”

Section: Discussionsupporting

confidence: 90%

“…Based on the prevalence and male:female ratio, the concurrence of both diseases is considered extremely rare; however, although limited, there have been some reported cases of the coexistence of both diseases. 18 , 19 In a French study by Rivière et al., 19 of 14 patients with concurrent TA and SpA including AS and psoriatic arthritis, 11 patients with AS were Caucasians, 10 of whom were women. Moreover, SpA preceded TA in 13 patients and the age at onset was 43.5 years, which was older than the general age of onset.…”

Section: Discussionmentioning

confidence: 99%

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A case of ankylosing spondylitis with concurrent Takayasu arteritis

et al. 2018

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We herein report a case involving a 56-year-old man who had experienced neck and lower back pain since the age of 23 years. Ankylosing spondylitis (AS) was diagnosed at 41 years of age, and treatment with sulfasalazine was initiated. At 44 years of age, the patient developed respiratory distress on exertion and chest pain. Aortic regurgitation (AR) was diagnosed via echocardiography, and the patient presented to our hospital for close examination and treatment. Coronary computed tomography angiography revealed no lesions in the coronary artery; however, magnetic resonance angiography revealed stenotic lesions in the left common carotid artery and left subclavian artery. Based on the findings of a physical examination, fundus examination, and blood tests, the patient was diagnosed with AS with concurrent Takayasu arteritis (TA). Upon administration of steroids to alleviate inflammation caused by an autoimmune mechanism, the patient’s chest symptoms and inflammatory findings improved. AR was treated with aortic valve replacement and prosthetic blood vessel replacement, after which the patient progressed well. Intraoperative aortic biopsy revealed findings pathologically consistent with TA. Although AS with concurrent AR is well described, AS with concurrent TA, as in the present case, is rare.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

A case of ankylosing spondylitis with concurrent Takayasu arteritis

et al. 2018

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“…Although the vascular manifestations of TAK are well known, the extravascular manifestations of TAK remain unclear. Some recent studies have addressed spondyloarthritis (SpA) [ 14 , 15 ] and inflammatory bowel disease (IBD) [ 16 , 17 ] in TAK patients. However, only sporadic case reports regarding other extravascular manifestations such as erythema nodosum [ 18 – 20 ] and uveitis [ 21 , 22 ] have been reported.…”

Section: Introductionmentioning

confidence: 99%

Extravascular manifestations of Takayasu arteritis: focusing on the features shared with spondyloarthritis

et al. 2018

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BackgroundTakayasu arteritis (TAK) is a systemic disease characterized by large vessel involvement. Although the vascular characteristics of TAK are well characterized, there is no well-organized study demonstrating the extravascular manifestations of TAK. We aimed to evaluate the characteristics of extravascular manifestations of TAK, and to identify the association between vascular and extravascular manifestations of TAK.MethodsTAK patients from two independent cohorts between January 2012 and October 2017 were included in the study. Patient characteristics were retrospectively collected from the electronic dataset. The computed tomography scans of all subjects were reviewed to evaluate the pattern of vascular involvement and presence of sacroiliitis. Clinical findings including uveitis, skin lesions, oral ulcers, arthritis, and inflammatory bowel disease (IBD) were reviewed. Logistic regression analysis was performed to evaluate the association between vascular and extravascular manifestations.ResultsFor the 268 TAK patients, the mean age at diagnosis was 41.2 ± 14.2 years and 88.1% were female. The extravascular manifestation of TAK was observed in 19.0% of patients, the most common being arthritis including sacroiliitis (11.9%) followed by recurrent oral ulcers (8.6%) and IBD (2.6%). A multivariate logistic regression analysis revealed type IIB vascular involvement (adjusted odds ratio (OR) 2.956, 95% confidence interval (CI) 1.337–6.537, p = 0.007) and the erythrocyte sedimentation rate (ESR) (adjusted OR 1.014, 95% CI 1.003–1.025, p = 0.012) as significantly associated with the presence of axial and peripheral arthritis.ConclusionsExtravascular manifestations of TAK were observed in up to one-fifth of patients. The most common extravascular manifestation was arthritis, which was associated with a type IIB vascular involvement pattern and a high ESR.

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“…Заболевание развивается преимущественно в возрасте 25-35 лет, причем у мужчин в 2 раза чаще [6]. Исходя из распространенности и соотношения мужчин и женщин, совпадение АС и АТ -крайне редкое явление, но имеются зарегистрированные случаи сосуществования этих заболеваний [11].…”

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Ankylosing spondylitis with concurrent Takayasu arteritis: a clinical case report

Несмеянова¹,

Khusainova²,

Богданова³

et al. 2019

Sovremennaâ revmatologiâ

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The paper describes a rare clinical case of ankylosing spondylitis (AS) with concurrent with Takayasu arteritis (AT). It considers the common immunopathogenetic mechanisms that can link these two diseases. Taking into account that there may be common triggering factors for AS and AT, it is necessary to make an examination to diagnose AT when a patient with AS is found to have fever, an increase in the indicators of acute phase inflammation, and the objective signs of cardiovascular disease characteristic of large-vessel vasculitis.

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Takayasu Arteritis and Spondyloarthritis: Coincidence or Association? A Study of 14 Cases

Cited by 19 publications

References 14 publications

A case of ankylosing spondylitis with concurrent Takayasu arteritis

A case of ankylosing spondylitis with concurrent Takayasu arteritis

Extravascular manifestations of Takayasu arteritis: focusing on the features shared with spondyloarthritis

Ankylosing spondylitis with concurrent Takayasu arteritis: a clinical case report

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