Takayasu arteritis: a review

Johnston, Sarah; Lock, R J; Gompels, Mark

doi:10.1136/jcp.55.7.481

Cited by 646 publications

(570 citation statements)

References 32 publications

(44 reference statements)

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“…Most studies say there is a correlation between pictures of ACS and elevated inflammatory markers with C-reactive protein and/or erythrocyte sedimentation rate 1 . However, as in our case, some case reports refer no direct association between active inflammation and coronary symptom 5 .…”

Section: Discussioncontrasting

confidence: 42%

Arterite de Takayasu: estenose pós implante de stent convencional e farmacológico

Soeiro¹,

Pinto²,

Henares³

et al. 2013

Arq. Bras. Cardiol.

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Section: Discussioncontrasting

confidence: 42%

Arterite de Takayasu: estenose pós implante de stent convencional e farmacológico

Soeiro¹,

Pinto²,

Henares³

et al. 2013

Arq. Bras. Cardiol.

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“…Second-line immunosuppressants like methotrexate (MTX), azathioprine (AZA), mycophenolate mofetil (MMF) and cyclophosphamide (CYC) have been tried along with steroids. 49 Other than the conventional immunosuppressants, biologics have also been tried in management, with good results. 50 In a North American series, remission was reported in 60% of patients treated with steroids alone and it was achieved faster in children as compared to adult patients.…”

Section: Treatmentmentioning

confidence: 99%

Childhood‐onset Takayasu arteritis: an update

et al. 2015

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Childhood-onset Takayasu arteritis (c-TA) is a distinct subset affecting a wide age group, ranging from young infants to adolescents and it differs from adult TA in many aspects. There is scarcity of data on c-TA worldwide. The disease is classified using the European League Against Rheumatism/Pediatric Rheumatology International Trials Organization/Pediatric Rheumatology European Society criteria. The non-specific nature of presenting complaints and lack of appropriate biomarkers delay the early diagnosis of this illness and many children present with complications, which become irreversible once they set in. One of the largest cohorts of 40 children with c-TA from our center reports hypertension as the commonest presenting feature. Systemic symptoms like headache, fever and weight loss are also described. Assessment of disease in c-TA is done by correlating clinical features with raised inflammatory markers. Advanced imaging plays an important role in diagnosis. In c-TA, the role of magnetic resonance angiography is advocated, taking into consideration the enormous amount of radiation exposure with other modalities. Complications of c-TA include cardiovascular, pulmonary, neurological and those arising secondary to long-term steroid and immunosuppression therapy.

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“…In the latter "burnt out" phase of the disease process, fibrosis and disruption of elastin occurs, leading to stenosis and aneurysmal formation. Necrotizing granuloma formation may also be seen [10].…”

Section: Rheumatologic Discussionmentioning

confidence: 99%

Large-Vessel Granulomatous Vasculitis in Crohn’s Disease

et al. 2010

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A 28-year-old African-American female with a past medical history of Crohn's disease and associated arthritis was evaluated for chest pain of 5-month duration that had become worse over the previous week. Her past medical history was significant for Crohn's disease diagnosed 7 years earlier when she presented with nonbloody diarrhea after a trip to Kenya. She underwent a colonoscopy that confirmed the diagnosis, and she was treated with mesalamine and steroids for 1 year at an outside institution. She had one flare of her bowel disease 2 years later, which required hospitalization for 2 days and was treated briefly with oral steroids. She also underwent a liver biopsy because of abnormal liver enzymes. This revealed primary sclerosing cholangitis which was not specifically treated at that time.Ten months prior to this presentation, the patient was admitted with a threatened abortion at 13 weeks of gestation along with an asymmetric polyarthritis of the fingers, wrists, elbows, shoulders, and ankles. During her hospitalization, she was noted to have a rash, characterized as minute follicular pustules, on the right side of her face and right upper extremity. She did not have any bowel symptoms at this time. Diagnostic workup revealed antiproteinase 3 (anti-PR-3) antibody of 536 AU/ml (normal <19 IU), rheumatoid factor (RF) of 24 IU/ml (normal 0-20 IU), erythrocyte sedimentation rate (ESR) of 139 mm/h (normal 0-20 mm/h), and C-reactive protein of 11.9 mg/dl (normal 0.30-0.80 mg/dl). A skin biopsy of the rash demonstrated vesiculopustular pyoderma gangrenosum consistent with her underlying Crohn's disease. Antinuclear antibodies, anti-double-stranded DNA antibodies, anti-streptolysin O antibody, viral hepatitis serologies, anticyclic citrullinated peptide, and human immunodeficiency virus testing were negative. She was started on 100 mg intravenous (IV) hydrocortisone three times daily for 3 days followed by 60 mg oral prednisone which was tapered off over the next 4 weeks. She also received two doses of 5 mg/kg infliximab 2 weeks apart.Six weeks later (gestational week 19), the patient presented with chest pain, arthritis, temperature of 38.7°C, and pulse of 130 beats per minute. A workup to reveal a source of infection was performed and was found to be negative. Also, an electrocardiogram, echocardiogram, and HSSJ

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Takayasu arteritis: a review

Cited by 646 publications

References 32 publications

Arterite de Takayasu: estenose pós implante de stent convencional e farmacológico

Arterite de Takayasu: estenose pós implante de stent convencional e farmacológico

Childhood‐onset Takayasu arteritis: an update

Large-Vessel Granulomatous Vasculitis in Crohn’s Disease

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