Tailoring ZE21B Alloy with Nature-Inspired Extracellular Matrix Secreted by Micro-Patterned Smooth Muscle Cells and Endothelial Cells to Promote Surface Biocompatibility

Liu, Changsheng; Chen, Lan; Zhang, Kun; Li, Jingan; Guan, Shaokang

doi:10.3390/ijms23063180

Cited by 16 publications

(6 citation statements)

References 57 publications

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“…After coating modification, the NiTi alloy showed better cell proliferation than BN samples, with 1.5 times higher cell number on day 5, which might stem from the involvement of exosomes in information exchange between HUVECs, thereby promoting the proliferation of HUVECs, which was consistent with previous findings that exosomes promoted cell proliferation. [55,56] Several studies showed [5,16,57] that the speed of endothelial cell proliferation and migration was critical for stent endothelialization. A scratch assay was employed to assess endothelial cell migration.…”

Section: Discussionmentioning

confidence: 99%

Preparation of ROS‐Responsive Exosome Coating of Nitinol Material for Making the Neurointerventional Stent

Duan

et al. 2023

Adv Materials Inter

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Nitinol (NiTi) alloy is an ideal material for preparing neurointerventional stents due to its excellent mechanical properties and biocompatibility. However, NiTi stents without surface‐specific functionalization cause a high rate of stent thrombosis and in‐stent restenosis after implantation. In ischemic stroke, exosomes have a role in regulating nervous system development, regeneration, vascular remodeling, and neuroinflammation. In this work, the effect of exosome coating on the biocompatibility of NiTi alloy is evaluated. NiTi alloy is successively immersed in relevant solution (sodium alginate, 3‐aminophenylboronic acid, distearoylphosphatidylethanolamine, and exosomes) to form ROS‐responsive exosome coated surfaces. In vitro experiments (platelets, endothelial cells, smooth muscle cells, and macrophages) and in vivo subcutaneous implantation experiments are performed to test coatings for biocompatibility. The results show that the modified NiTi alloy surface has high hydrophilicity, which has the functions of inhibiting platelet aggregation, promoting endothelialization, inhibiting smooth muscle cell migration, anti‐inflammatory, and good tissue biocompatibility. This study develops exosome neurointerventional stent coating as a bioactive drug via reactive oxygen species accumulation in lesions, thus targeting drug release, inhibiting intimal hyperplasia, and reducing inflammation and thrombosis.

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Section: Discussionmentioning

confidence: 99%

Preparation of ROS‐Responsive Exosome Coating of Nitinol Material for Making the Neurointerventional Stent

Duan

et al. 2023

Adv Materials Inter

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“…Sulfonation is an effective chemical modification method of HA molecules, which can not only improve their stability in vivo but also greatly improve a variety of biological functions, such as antiinflammatory, promoting physiological cell proliferation, and so on (Yu et al, 2020). Data showed that HA with a higher sulfonation degree had stronger functions of inhibiting inflammatory macrophages, promoting the adhesion, proliferation, and migration of EC and regulating and maintaining the contractile phenotype of SMCs (Yu et al, 2020), which is a promising potential FIGURE 6 | Fabrication of the biomimetic vascular basement membrane with the ECM secreted from the SMC and EC controlled by HA micro-patterned on the non-biodegradable and biodegradable material surfaces (Liu et al, 2022).…”

Section: Hyaluronic Acid Hydrogelsmentioning

confidence: 99%

“…Inspired by another de-cellularized technology, the ECM secreted by the HA-patterned EC was deposited on the cardiovascular implanted material surface ( Figure 6 ), which enhanced their biocompatibility ( Zou et al, 2019 ). The structure and function of the vascular basement membrane provide more enlightenment, and the ECM secreted by the HA-patterned EC and SMCs endows the materials with stronger multi-functions than the single HA-patterned EC-ECM ( Liu et al, 2022 ).…”

Section: Biomaterials Prepared With Hyaluronic Acidmentioning

confidence: 99%

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Advances in Hyaluronic Acid for Biomedical Applications

Yasin

Ren

et al. 2022

Front. Bioeng. Biotechnol.

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Hyaluronic acid (HA) is a large non-sulfated glycosaminoglycan that is the main component of the extracellular matrix (ECM). Because of its strong and diversified functions applied in broad fields, HA has been widely studied and reported previously. The molecular properties of HA and its derivatives, including a wide range of molecular weights but distinct effects on cells, moisture retention and anti-aging, and CD44 targeting, promised its role as a popular participant in tissue engineering, wound healing, cancer treatment, ophthalmology, and cosmetics. In recent years, HA and its derivatives have played an increasingly important role in the aforementioned biomedical fields in the formulation of coatings, nanoparticles, and hydrogels. This article highlights recent efforts in converting HA to smart formulation, such as multifunctional coatings, targeted nanoparticles, or injectable hydrogels, which are used in advanced biomedical application.

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“…However, the application of this doublelayer ECM is limited because it is not easy to be directly prepared onto the biodegradable or uneven materials. To solve this problem, Liu et al dispersed the double layer ECM into normal saline using the ultrasonic vibration method, and then self-assembled it onto the surface of biodegradable Mg alloy (ZE21B) (Figure 4), thereby improving the corrosion resistance and biocompatibility of ZE21B [97]. It is unknown whether the process of preparing the ECM solution by ultrasonic vibration will cause losses to its components.…”

Section: Nature-inspired Ecm Coatingmentioning

confidence: 99%

Extracellular Matrix Coatings on Cardiovascular Materials—A Review

et al. 2022

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Vascular transplantation is an effective and common treatment for cardiovascular disease (CVD). However, the low biocompatibility of implants is a major problem that hinders its clinical application. Surface modification of implants with extracellular matrix (ECM) coatings is an effective approach to improve the biocompatibility of cardiovascular materials. The complete ECM seems to have better biocompatibility, which may give cardiovascular biomaterials a more functional surface. The use of one or several ECM proteins to construct a surface allows customization of coating composition and structure, possibly resulting in some unique functions. ECM is a complex three-dimensional structure composed of a variety of functional biological macromolecules, and changes in the composition will directly affect the function of the coating. Therefore, understanding the chemical composition of the ECM and its interaction with cells is beneficial to provide new approaches for coating surface modification. This article reviews novel ECM coatings, including coatings composed of intact ECM and biomimetic coatings tailored from several ECM proteins, and introduces new advances in coating fabrication. These ECM coatings are effective in improving the biocompatibility of vascular grafts.

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Tailoring ZE21B Alloy with Nature-Inspired Extracellular Matrix Secreted by Micro-Patterned Smooth Muscle Cells and Endothelial Cells to Promote Surface Biocompatibility

Cited by 16 publications

References 57 publications

Preparation of ROS‐Responsive Exosome Coating of Nitinol Material for Making the Neurointerventional Stent

Preparation of ROS‐Responsive Exosome Coating of Nitinol Material for Making the Neurointerventional Stent

Advances in Hyaluronic Acid for Biomedical Applications

Extracellular Matrix Coatings on Cardiovascular Materials—A Review

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