Extracellular Matrix Coatings on Cardiovascular Materials—A Review

Yao, Siyu; Cui, Jixiang; Chen, Shuyao; Zhou, Xiao; Li, Jingan; Zhang, Kun

doi:10.3390/coatings12081039

Cited by 12 publications

(15 citation statements)

References 113 publications

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“…Inadequate re-endothelialization can lead to complications such as restenosis, thrombosis, inflammation, and impaired vasomotor function, emphasizing the importance of supporting this regenerative process in medical interventions and treatments to avoid adverse vascular outcomes. One approach is the use of biomimetic coatings composed of an endothelial extracellular matrix (EC-ECM) and specific micropatterns [74]. These coatings have shown good blood compatibility, anti-inflammatory properties, and the ability to promote endothelialization while inhibiting smooth muscle cell proliferation and macrophage attachment.…”

Section: Biomimetic Coatingsmentioning

confidence: 99%

“…Researchers have successfully created biomimetic coatings by culturing endothelial cells (ECs) on micropatterned surfaces and then decellularizing the resulting ECM. By incorporating hyaluronic acid (HA) micropatterns, cell morphology is prolonged, leading to increased release of anticoagulant factors and limiting the contractile phenotype of smooth muscle cells (SMCs) [74]. This approach improves the biocompatibility of the EC-ECM coating, as demonstrated by its anticoagulation, endothelialization, and anti-inflammatory properties.…”

Section: Biomimetic Coatingsmentioning

confidence: 99%

“…To facilitate the application of ECM coatings on biodegradable or uneven materials, researchers have developed methods of dispersing the ECM into a solution and selfassembling it onto the material surface [74]. Heparin, a natural polysaccharide with antithrombotic properties, can be immobilized on the ECM coating to selectively promote EC proliferation while inhibiting SMC growth, further enhancing blood compatibility [40].…”

Section: Biomimetic Coatingsmentioning

confidence: 99%

“…The molecular weight (MW) of hyaluronic acid has an important role in the biocompatibility of the coatings. High MW HA inhibits the adhesion of platelets, SMC, and macrophages, providing anticoagulant, anti-proliferative, anti-inflammatory, and non-immunogenic properties [74]. Extremely high MW HA may hinder endothelialization.…”

Section: Biomimetic Coatingsmentioning

confidence: 99%

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Surface Engineering of Bioactive Coatings for Improved Stent Hemocompatibility: A Comprehensive Review

Raikar,

Priya,

Bhilegaonkar

et al. 2023

Materials

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Cardiovascular diseases continue to be a major contributor to illness and death on a global scale, and the implementation of stents has given rise to a revolutionary transformation in the field of interventional cardiology. The thrombotic and restenosis complications associated with stent implantation pose ongoing challenges. In recent years, bioactive coatings have emerged as a promising strategy to enhance stent hemocompatibility and reduce thrombogenicity. This review article provides an overview of the surface engineering techniques employed to improve the hemocompatibility of stents and reduce thrombus formation. It explores the mechanisms underlying thrombosis and discusses the factors influencing platelet activation and fibrin formation on stent surfaces. Various bioactive coatings, including anticoagulant agents, antiplatelet agents, and surface modifications, are discussed in detail, highlighting their potential in reducing thrombogenicity. This article also highlights a multitude of surface modification techniques which can be harnessed to enhance stent hemocompatibility including plasma treatment, physical vapor deposition (PVD), chemical vapor deposition (CVD), and electrodeposition. These techniques offer precise control over surface properties such as roughness, charge, and composition. The ultimate goal is to reduce platelet adhesion, tailor wettability, or facilitate the controlled release of bioactive agents. Evaluation methods for assessing hemocompatibility and thrombogenicity are also reviewed, ranging from in vitro assays to animal models. Recent advances in the field, such as nanotechnology-based coatings and bioactive coatings with controlled drug release systems, are highlighted. Surface engineering of bioactive coatings holds great promise for enhancing the long-term outcomes of stent implantation by enhancing hemocompatibility and reducing thrombogenicity. Future research directions and potential clinical applications are discussed, underscoring the need for continued advancements in this field.

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Section: Biomimetic Coatingsmentioning

confidence: 99%

Section: Biomimetic Coatingsmentioning

confidence: 99%

Section: Biomimetic Coatingsmentioning

confidence: 99%

Section: Biomimetic Coatingsmentioning

confidence: 99%

See 2 more Smart Citations

Surface Engineering of Bioactive Coatings for Improved Stent Hemocompatibility: A Comprehensive Review

Raikar,

Priya,

Bhilegaonkar

et al. 2023

Materials

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show abstract

“…All of the medical studies seem to be different from those with the tribological point of view that many various requirements must be met, such as antibacterial [49] properties. Another issue, the biocompatibility of implants [50,51], can be mentioned as a major problem that can hinder the clinical application of surfaces. Some actions, such as, e.g., chemical bonding [52], can improve the bioactivity of selected types of surfaces.…”

mentioning

confidence: 99%