Tailoring thermoresponsive microbeads in supercritical carbon dioxide for biomedical applications

Costa, Evaldo; de-Carvalho, Jorge; Casimiro, Teresa; Silva, Cláudia Lobato da; Cidade, M. T.; Aguiar‐Ricardo, Ana

doi:10.1016/j.supflu.2010.10.039

Cited by 14 publications

(17 citation statements)

References 34 publications

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“…A fine balance between hydrophobic and hydrophilic moieties in the molecular structure determined the LCST of this polymer (between 30 and 31 °C). 144 …”

Section: Synthesis Methods Of Thermosensitive Npsmentioning

confidence: 99%

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Karimi

Zangabad

Ghasemi

et al. 2016

ACS Appl. Mater. Interfaces

317

212

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Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as carriers that can be stimulated by changes in environmental parameters such as temperature, pH, light, electromagnetic fields, mechanical forces, etc. These smart nanocarriers can release their cargo on demand when their target is reached and the stimulus is applied. Using the techniques of nanotechnology, these nanocarriers can be tailored to be target-specific, and exhibit delayed or controlled release of drugs. Temperature-responsive nanocarriers are one of most important groups of smart nanoparticles (NPs) that have been investigated during the past decades. Temperature can either act as an external stimulus when heat is applied from the outside, or can be internal when pathological lesions have a naturally elevated termperature. A low critical solution temperature (LCST) is a special feature of some polymeric materials, and most of the temperature-responsive nanocarriers have been designed based on this feature. In this review, we attempt to summarize recent efforts to prepare innovative temperature-responsive nanocarriers and discuss their novel applications.

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“…A fine balance between hydrophobic and hydrophilic moieties in the molecular structure determined the LCST of this polymer (between 30 and 31 °C). 144 …”

Section: Synthesis Methods Of Thermosensitive Npsmentioning

confidence: 99%

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Karimi

Zangabad

Ghasemi

et al. 2016

ACS Appl. Mater. Interfaces

317

212

View full text Add to dashboard Cite

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“…26,34 Herein the monomers at a concentration of 5.2 wt % relative to CO 2 and Krytox 157 FSL at 10 wt % relative to the monomers amount were charged into a high-pressure cell at 28.0 MPa and 65 °C. At these experimental conditions, an initial homogeneous phase was obtained with all the reactants completely soluble in the supercritical medium.…”

Section: Methodsmentioning

confidence: 99%

Tuning Smart Microgel Swelling and Responsive Behavior through Strong and Weak Polyelectrolyte Pair Assembly

et al. 2012

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The layer-by-layer (LbL) assembly of polyelectrolyte pairs on temperature and pH-sensitive cross-linked poly(N-isopropylacrylamide)-co-(methacrylic acid), poly(NIPAAm-co-MAA), microgels enabled a fine tuning of the gel swelling and responsive behavior according to the mobility of the assembled polyelectrolyte (PE) pair and the composition of the outermost layer. Microbeads with well-defined morphology were initially prepared by synthesis in supercritical carbon dioxide. Upon LbL assembly of polyelectrolytes, interactions between the multilayers and the soft porous microgel led to differences in swelling and thermoresponsive behavior. For the weak PE pairs, namely poly(L-lysine) / poly(L-glutamic acid) and poly(allylamine hydrochloride) / poly(acrylic acid), polycation-terminated microgels were less swollen and more thermoresponsive than native microgel; while polyanion-terminated microgels were more swollen and not significantly responsive to temperature, in a quasi-reversible process with consecutive PE assembly. For the strong PE pair, poly(diallyldimethylammonium chloride) / poly(sodium styrene sulfonate), the differences among polycation and polyanion-terminated microgels are not sustained after the first PE bilayer due to extensive ionic cross-linking between the polyelectrolytes. The tendencies across the explored systems became less noteworthy in solutions with larger ionic strength due to overall charge shielding of the polyelectrolytes and microgel. ATR FT-IR studies correlated the swelling and responsive behavior after LbL assembly on the microgels with the extent of H-bonding and alternating charge distribution within the gel. Thus, the proposed LbL strategy may be a simple and flexible way to engineer smart microgels in terms of size, surface chemistry, overall charge and permeability.

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“…However, the use of MBA as an additional crosslinker was necessary due to the low DS obtained in the modification reaction of starch. MBA has been used in several devices aiming biomedical application and has been proven to be safe as crosslinker (Costa et al, 2011;Mandal, Kapoor, & Kundu, 2009). Therefore, the use of MBA in the preparation of starch-mod microspheres does not compromise its potential as a device for drug delivery system.…”

Section: Microspheres Preparationmentioning

confidence: 99%

Starch-based microspheres for sustained-release of curcumin: Preparation and cytotoxic effect on tumor cells

Pereira

Fajardo

Nocchi³

et al. 2013

Carbohydrate Polymers

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Tailoring thermoresponsive microbeads in supercritical carbon dioxide for biomedical applications

Cited by 14 publications

References 34 publications

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Tuning Smart Microgel Swelling and Responsive Behavior through Strong and Weak Polyelectrolyte Pair Assembly

Starch-based microspheres for sustained-release of curcumin: Preparation and cytotoxic effect on tumor cells

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