Starch-based microspheres for sustained-release of curcumin: Preparation and cytotoxic effect on tumor cells

Pereira, Antonio G.B.; Fajardo, André R.; Nocchi, Samara Requena; Nakamura, Celso V.; Rubira, Adley F.; Muniz, Edvani C.

doi:10.1016/j.carbpol.2013.06.013

Cited by 75 publications

(13 citation statements)

References 57 publications

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“…At simulated gastric fluid the fraction released of CUR was 100% and in a controlled manner, due to the sustained diffusion of CUR to the media and also due to the degradation of the polymer matrix. The CUR-loaded microspheres presented much higher activity against Caco-2 and HCT-116 tumor cell lines than free CUR 104 . Hasan et al 105 reported an approach of encapsulation a CUR by nanoliposome to achieve an improved bioavailability of a poorly absorbed hydrophobic compound and also demonstrated that liposomal preparations to deliver CUR increase its bioavailability.…”

Section: Biological Activities Of Various Curcuminoid Formulationsmentioning

confidence: 99%

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Amalraj¹,

Pius

Gopi

et al. 2017

Journal of Traditional and Complementary Medicine

708

413

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In recent years, several drugs have been developed deriving from traditional products and current drug research is actively investigating the possible therapeutic roles of many Ayruvedic and Traditional Indian medicinal therapies. Among those being investigated is Turmeric. Its most important active ingredient is curcuminoids. Curcuminoids are phenolic compounds commonly used as a spice, pigment and additive also utilized as a therapeutic agent used in several foods. Comprehensive research over the last century has revealed several important functions of curcuminoids. Various preclinical cell culture and animals studies suggest that curcuminoids have extensive biological activity as an antioxidant, neuroprotective, antitumor, anti-inflammatory, anti-acidogenic, radioprotective and arthritis. Different clinical trials also suggest a potential therapeutic role for curcuminoids in numerous chronic diseases such as colon cancer, lung cancer, breast cancer, inflammatory bowel diseases. The aim of this review is to summarize the chemistry, analog, metal complex, formulations of curcuminoids and their biological activities.

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Section: Biological Activities Of Various Curcuminoid Formulationsmentioning

confidence: 99%

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Amalraj¹,

Pius

Gopi

et al. 2017

Journal of Traditional and Complementary Medicine

708

413

View full text Add to dashboard Cite

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“…The positive implications of dietary therapies for improvement of the metabolic hallmarks of inflammation, dysregulated metabolism, genomic instability and immune system evasion should be kept in mind [250,251]. Clinicians choosing to use natural product supplements should attend to product quality and be familiar with advances in the formulation of poorly absorbed polyphenols and other phytochemicals [201–203]. …”

Section: Discussionmentioning

confidence: 99%

“…Alternatively, pharmacological doses (2–4 g/day) administered orally [199] may saturate the metabolic pathways of conjugation [200]. Efforts are being made, however, to improve bioavailability of these agents, such as microspheres [201], liposomes [202] and nanoparticles [203]. An additional complication is that individuals may vary in their absorption, distribution, metabolism and elimination of phytochemicals, based in some instances on genetic variability [204], dietary habits [205] and potentially on intestinal microbiota [206].…”

Section: Proposed Research Modelmentioning

confidence: 99%

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Block

Gyllenhaal

Lowe

et al. 2015

Seminars in Cancer Biology

240

191

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Targeted therapies and the consequent adoption of “personalized” oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are not reliant upon the same mechanisms as those which have been targeted). To address these limitations, an international task force of 180 scientists was assembled to explore the concept of a low-toxicity “broad-spectrum” therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspects of relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a wide range of high-priority targets (74 in total) that could be modified to improve patient outcomes. For these targets, corresponding low-toxicity therapeutic approaches were then suggested; many of which were phytochemicals. Proposed actions on each target and all of the approaches were further reviewed for known effects on other hallmark areas and the tumor microenvironment. Potential contrary or procarcinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixed evidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of the relationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. This novel approach has potential to help us address disease relapse, which is a substantial and longstanding problem, so a proposed agenda for future research is offered.

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“…In fact, curcumin hydrophobicity disables its vascular and oral administration which results in poor absorption and reduced bioavailability after its administration . In order to overcome these problems, it is necessary to develop an adequate releasing formulations (hydrogels, liposome, dendrimer, micro/nano particles) for delivery of curcumin which has been explored for long time . Among these delivering formulations, biodegradable polymeric particles have been widely used as carriers for curcumin delivery with improved therapeutic efficacy .…”

Section: Introductionmentioning

confidence: 99%

“…In order to overcome these problems, it is necessary to develop an adequate releasing formulations (hydrogels, liposome, dendrimer, micro/nano particles) for delivery of curcumin which has been explored for long time . Among these delivering formulations, biodegradable polymeric particles have been widely used as carriers for curcumin delivery with improved therapeutic efficacy . Some characteristics of starch like its hydrophilic nature, biocompatibility, biodegradability, and its low‐cost; makes it a promising candidate for drug delivery applications .…”

Section: Introductionmentioning

confidence: 99%

Curcumin-Loaded Starch Micro/Nano Particles for Biomedical Application: The Effects of Preparation Parameters on Release Profile

et al. 2019

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Although curcumin is highly cytotoxic against cancer cells, its hydrophobicity and fast degradation at physiological pH limit its effective practical application. To prevent such limitations, inexpensive curcumin‐loaded starch particles are synthesized in this research. Particles are prepared by water‐in‐oil (W/O) miniemulsion technique and an adsorption method is used for curcumin loading. Also, encapsulation efficiency (%EE) is improved by using pluronic F‐127 in the drug solution. Particles are characterized, swelling studies are performed, and MTT assays against human adipose mesenchymal stem cells (hAMSCs) and MG‐63 cells are utilized for investigations. Results indicate that crosslinker, surfactant, and stirring rate affect the swelling degree of bare particles as well as %EE and release profile of drug‐loaded particles. Moreover, swelling degree, %EE, and burst release are modeled by design of experiments via response surface method. Due to analysis of variance, the responses can be predicted by quadratic models within the design space. Also, cell viability studies depict that curcumin encapsulation improves its cytotoxic effect on MG‐63 cells due to its sustained release while it has no cytotoxic effect on hAMSCs. In addition, it can be concluded that curcumin sustained release plays a more crucial role on cell viability of cancer cells compared to %EE. Consequently, it can be stated that curcumin‐loaded starch particles have good potential as drug delivery systems for osteosarcoma therapy.

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Starch-based microspheres for sustained-release of curcumin: Preparation and cytotoxic effect on tumor cells

Cited by 75 publications

References 57 publications

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Curcumin-Loaded Starch Micro/Nano Particles for Biomedical Application: The Effects of Preparation Parameters on Release Profile

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