Tailoring the surface characteristics of electrophoretically deposited chitosan-based bioactive glass composite coatings on titanium implants via grit blasting

Avcu, Egemen; Avcu, Yasemin Yıldıran; Baştan, Fatih Erdem; Rehman, Muhammad Atiq Ur; Üstel, Fatih; Boccaccını, Aldo R.

doi:10.1016/j.porgcoat.2018.07.021

Cited by 47 publications

(37 citation statements)

References 67 publications

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“…However, there is a slight shift in the chitosan-related peaks to the lower wavenumbers in the FTIR spectra of chitosan/curcumin coatings. For example, the C-O band at 1054 cm −1 [47,48] shifted to 1025 cm −1 , the C-H band at 1401 cm −1 shifted to 1375 cm −1 , and the N-H band at 1530 cm −1 shifted to 1506 cm −1 [49,50]. The slight shift in the chitosan-related peaks in the FTIR spectra of chitosan/curcumin coatings indicated the possibility of bonding between chitosan and curcumin.…”

Section: Coating Of Chitosan/curcumin On 316l Ssmentioning

confidence: 96%

“…The characteristic peaks of chitosan were found in the multilayer as well as in chitosan/curcumin single coatings; the carbonyl functional group (C-O) of chitosan was found at 1080 cm −1 [47,48,51]. The broad band at about 1022 cm −1 may have appeared because of the overlap of the C-O bond in chitosan and the bond corresponding to network modifiers in the glass structure [25,49,51]. Furthermore, the peak found at 1408 cm -1 is assigned to the asymmetrical bending in C-H, and the peak at about 1570 cm −1 is attributed to N-H bonding vibration of chitosan [52,53].…”

Section: Ftir Analysismentioning

confidence: 99%

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Curcumin-Containing Orthopedic Implant Coatings Deposited on Poly-Ether-Ether-Ketone/Bioactive Glass/Hexagonal Boron Nitride Layers by Electrophoretic Deposition

et al. 2019

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Electrophoretic deposition (EPD) was used to produce a multilayer coatings system based on chitosan/curcumin coatings on poly-ether-ether-ketone (PEEK)/bioactive glass (BG)/hexagonal boron nitride (h-BN) layers (previously deposited by EPD on 316L stainless steel) to yield bioactive and antibacterial coatings intended for orthopedic implants. Initially, PEEK/BG/h-BN coatings developed on 316L stainless steel (SS) substrates were analyzed for wear studies. Then, the EPD of chitosan/curcumin was optimized on 316L SS for suspension stability, thickness, and homogeneity of the coatings. Subsequently, the optimized EPD parameters were applied to produce chitosan/curcumin coatings on the PEEK/BG/h-BN layers. The multilayered coatings produced by EPD were characterized in terms of composition, microstructure, drug release kinetics, antibacterial activity, and in vitro bioactivity. Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) confirmed the deposition of chitosan/curcumin on the multilayer coating system. The release of curcumin upon immersion of multilayer coatings in phosphate-buffered saline (PBS) was confirmed by ultraviolet/visible (UV/VIS) spectroscopic analysis. The antibacterial effect of chitosan/curcumin as the top coating was determined by turbidity tests (optical density measurements). Moreover, the multilayer coating system formed an apatite-like layer upon immersion in simulated body fluid (SBF), which is similar in composition to the hydroxyapatite component of bone, confirming the possibility of achieving close bonding between bone and the coating surface.

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Section: Coating Of Chitosan/curcumin On 316l Ssmentioning

confidence: 96%

Section: Ftir Analysismentioning

confidence: 99%

Curcumin-Containing Orthopedic Implant Coatings Deposited on Poly-Ether-Ether-Ketone/Bioactive Glass/Hexagonal Boron Nitride Layers by Electrophoretic Deposition

et al. 2019

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“…Currently used commercial titanium implants satisfy the required mechanical properties with a Young's modulus within the range of 100–120 GPa . Coating the implant surface with a mesoporous film is an attractive method to improve biocompatibility, as rougher surfaces promote bone and implant interlocking . Mesoporous materials have an ordered, homogeneous distribution of interconnected pores whose diameters are in the 2–50 nm range .…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Mesoporous Titania Films with Embedded Gentamicin and Surface Modified with Bone Morphogenetic Protein 2 to Promote Osseointegration in Bone Implants

Escobar

Muzzio

Coy

et al. 2019

Adv Materials Inter

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Novel approaches are needed to avoid bacterial infections following implant surgery. Here the use of mesoporous titania films (MTFs) for gentamicin loading and delivery and the surface functionalization of MFTs with human recombinant bone morphogenetic protein 2 (hrBMP‐2) are discussed. Gentamicin is incorporated into the MTF pores by immersion of the porous materials in gentamicin solution while hrBMP‐2 is adsorbed on top of the MTF. Contact angle and X‐ray photoelectron spectroscopy measurements are performed to prove gentamicin loading and hrBMP‐2 functionalization. An initial burst release of gentamicin takes place in physiological media followed by a prolonged release that lasts weeks. Such a release profile is highly appealing for bone implants where a high concentration of antibiotics is necessary during implant surgery while a lower antibiotic concentration is needed until tissue is regenerated. The MTFs loaded with gentamicin and functionalized with hrBMP‐2 are effective against Staphylococcus aureus colonization, and the presence of hrBMP‐2 enhances MC3T3‐E1 preosteoblastic cell attachment, proliferation, and differentiation.

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“…As far as coating synthesis is concerned, ATR-FTIR spectroscopy is widely used to confirm coating formation on titanium [51][52][53][54][55][56][57][58]. For example, the hydroxyapatite/lignin composite coatings on titanium implants, developed by Erakovic et al, were also studied by means of ATR-FTIR.…”

Section: Attenuated Total Reflectance Fourier-transform Infrared Specmentioning

confidence: 99%

“…Most of the aforementioned works reported SEM analysis, together with the other characterizations, in order to gain insights into the morphology of titanium polymeric coatings obtained by electrochemical routes [34,51,[53][54][55][56][57][58][61][62][63]81].…”

Section: Scanning Electron Microscopy With Energy-dispersive X-ray Anmentioning

confidence: 99%

Surface Characterization of Electro-Assisted Titanium Implants: A Multi-Technique Approach

et al. 2020

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The understanding of chemical–physical, morphological, and mechanical properties of polymer coatings is a crucial preliminary step for further biological evaluation of the processes occurring on the coatings’ surface. Several studies have demonstrated how surface properties play a key role in the interactions between biomolecules (e.g., proteins, cells, extracellular matrix, and biological fluids) and titanium, such as chemical composition (investigated by means of XPS, TOF-SIMS, and ATR-FTIR), morphology (SEM–EDX), roughness (AFM), thickness (Ellipsometry), wettability (CA), solution–surface interactions (QCM-D), and mechanical features (hardness, elastic modulus, adhesion, and fatigue strength). In this review, we report an overview of the main analytical and mechanical methods commonly used to characterize polymer-based coatings deposited on titanium implants by electro-assisted techniques. A description of the relevance and shortcomings of each technique is described, in order to provide suitable information for the design and characterization of advanced coatings or for the optimization of the existing ones.

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Tailoring the surface characteristics of electrophoretically deposited chitosan-based bioactive glass composite coatings on titanium implants via grit blasting

Cited by 47 publications

References 67 publications

Curcumin-Containing Orthopedic Implant Coatings Deposited on Poly-Ether-Ether-Ketone/Bioactive Glass/Hexagonal Boron Nitride Layers by Electrophoretic Deposition

Curcumin-Containing Orthopedic Implant Coatings Deposited on Poly-Ether-Ether-Ketone/Bioactive Glass/Hexagonal Boron Nitride Layers by Electrophoretic Deposition

Antibacterial Mesoporous Titania Films with Embedded Gentamicin and Surface Modified with Bone Morphogenetic Protein 2 to Promote Osseointegration in Bone Implants

Surface Characterization of Electro-Assisted Titanium Implants: A Multi-Technique Approach

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