Tailoring Material Properties of Cardiac Matrix Hydrogels To Induce Endothelial Differentiation of Human Mesenchymal Stem Cells

Jeffords, Megan E.; Wu, Jinglei; Shah, Mickey; Hong, Yi; Zhang, Ge

doi:10.1021/acsami.5b03195

Cited by 100 publications

(135 citation statements)

References 45 publications

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“…Several electronic structure factors have been used as descriptors representing the OER efficiency, including features (energy, filling, and width) of the electronic states, [43,49,50] the metal-oxygen covalency, [51,52] and the number of electrons with specific symmetry (Figure 2b). [18,53] Such descriptors enable simple prediction of efficiency without rigorously calculating the four-step energies in the OER.…”

Section: Wwwadvenergymatdementioning

confidence: 99%

Recent Progress on Multimetal Oxide Catalysts for the Oxygen Evolution Reaction

Kim

et al. 2018

Advanced Energy Materials

664

498

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fossil fuels are being widely researched for the development of a sustainable energy system. Among the various candidates for green energy resources, hydrogen energy has been at the center of attention. [1,2] Hydrogen is both inexhaustible and environmentally friendly, because it can be produced from earth-abundant reactants such as water and methane and because no CO 2 or other toxic products are emitted during its conversion into other energy form such as electricity, respectively. Moreover, hydrogen can exhibit significantly larger energy density compared with other energy sources such as gasoline and coal. The most widely used method of hydrogen production today is steam reforming because of its low cost in the process. [3] Nevertheless, the release of carbon monoxide or carbon dioxide as byproducts in the steam reforming process diminishes the environmental merits of hydrogen energy. Thus, as a possible cleaner alternative, an electrolysis method that involves producing hydrogen by electrochemically splitting water has been extensively investigated. Using one of the most abundant resources, water, the production of hydrogen from it yields only oxygen as a byproduct.In the water electrolysis, the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) occur simultaneously, as described by the following equationsIn order for the reaction to proceed, a voltage of 1.23 V is theoretically required between an anode and a cathode. However, an overpotential (represented by the symbol η) should be additionally applied to account for the potential loss resulting from kinetic limitations occurring during the electrochemical reaction. The use of electrocatalysts can lower the overpotential by kinetically facilitating the water-splitting reaction either in HER or OER. Due to the nature of four-electron involving OER, it is generally believed that the OER is much more sluggish than the HER; thus, the development of efficient OER Hydrogen is a promising alternative fuel for efficient energy production and storage, with water splitting considered one of the most clean, environmentally friendly, and sustainable approaches to generate hydrogen. However, to meet industrial demands with electrolysis-generated hydrogen, the development of a low-cost and efficient catalyst for the oxygen evolution reaction (OER) is critical, while conventional catalysts are mostly based on precious metals. Many studies have thus focused on exploring new efficient nonprecious-metal catalytic systems and improving the understandings on the OER mechanism, resulting in the design of catalysts with superior activity compared with that of conventional catalysts. In particular, the use of multimetal rather than single-metal catalysts is demonstrated to yield remarkable performance improvement, as the metal composition in these catalysts can be tailored to modify the intrinsic properties affecting the OER. Herein, recent progress and accomplishments of multimetal catalytic systems, including several important groups of catalysts: layered h...

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Section: Wwwadvenergymatdementioning

confidence: 99%

Recent Progress on Multimetal Oxide Catalysts for the Oxygen Evolution Reaction

Kim

et al. 2018

Advanced Energy Materials

664

498

View full text Add to dashboard Cite

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“…The capability to reintegrate this knowledge with therapy is now beginning to take form. Jeffords and colleagues have developed cardiac matrix hydrogels using a genipin cross-linker to more accurately mimic the stiffness conditions favourable for endothelial revascularization of infarcted heart tissue [54, 91, 92]. Interestingly, the application of an acellular ECM substitute composed of high stiffness hyaluronic acid provided better cardiac function after myocardial infarction (MI).…”

Section: Regenerative Goalsmentioning

confidence: 99%

The extracellular microscape governs mesenchymal stem cell fate

Hadden

Choi

2016

J Biol Eng

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Each cell forever interacts with its extracellular matrix (ECM); a stem cell relies on this interaction to guide differentiation. The stiffness, nanotopography, protein composition, stress and strain inherent to any given ECM influences stem cell lineage commitment. This interaction is dynamic, multidimensional and reciprocally evolving through time, and from this concerted exchange the macroscopic tissues that comprise living organisms are formed. Mesenchymal stem cells can give rise to bone, cartilage, tendon and muscle; thus attempts to manipulate their differentiation must heed the physical properties of incredibly complex native microenvironments to realize regenerative goals.

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“…The mechanical properties and degradation of the myocardium ECM hydrogel can be mediated through chemical cross-linking. Jeffords et al 142 used a natural cross-linker, genipin, to stabilize the ECM hydrogel, thereby increasing the mechanical strength and reducing the degradation rate. They found that 1 mM genipin cross-linked ECM hydrogel promoted vascular differentiation of hMSCs with significant expression of mature endothelial cell marker vWF without the need for exogenous growth factor addition.…”

Section: Current Attempts In Establishing Early Functional Perfusmentioning

confidence: 99%

Establishing Early Functional Perfusion and Structure in Tissue Engineered Cardiac Constructs

Wang

Patnaik

Brazile

et al. 2015

Crit Rev Biomed Eng

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Myocardial infarction (MI) causes massive heart muscle death and remains a leading cause of death in the world. Cardiac tissue engineering aims to replace the infarcted tissues with functional engineered heart muscles or revitalize the infarcted heart by delivering cells, bioactive factors, and/or biomaterials. One major challenge of cardiac tissue engineering and regeneration is the establishment of functional perfusion and structure to achieve timely angiogenesis and effective vascularization, which are essential to the survival of thick implants and the integration of repaired tissue with host heart. In this paper, we review four major approaches to promoting angiogenesis and vascularization in cardiac tissue engineering and regeneration: delivery of pro-angiogenic factors/molecules, direct cell implantation/cell sheet grafting, fabrication of prevascularized cardiac constructs, and the use of bioreactors to promote angiogenesis and vascularization. We further provide a detailed review and discussion on the early perfusion design in nature-derived biomaterials, synthetic biodegradable polymers, tissue-derived acellular scaffolds/whole hearts, and hydrogel derived from extracellular matrix. A better understanding of the current approaches and their advantages, limitations, and hurdles could be useful for developing better materials for future clinical applications.

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Tailoring Material Properties of Cardiac Matrix Hydrogels To Induce Endothelial Differentiation of Human Mesenchymal Stem Cells

Cited by 100 publications

References 45 publications

Recent Progress on Multimetal Oxide Catalysts for the Oxygen Evolution Reaction

Recent Progress on Multimetal Oxide Catalysts for the Oxygen Evolution Reaction

The extracellular microscape governs mesenchymal stem cell fate

Establishing Early Functional Perfusion and Structure in Tissue Engineered Cardiac Constructs

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