Tailoring immediate release FDM 3D printed tablets using a quality by design (QbD) approach

Than, Yee Mon; Titapiwatanakun, Varin

doi:10.1016/j.ijpharm.2021.120402

Cited by 38 publications

(26 citation statements)

References 79 publications

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“…Due to its chemical characteristics, EE has been the most used in the development of 3D printed immediate drug release formulations. To improve the printability of EE filaments, mixtures with other polymers like hydroxypropyl cellulose [ 139 ], polyethylene oxide [ 136 ] and excipients like plasticizers [ 132 , 138 ] have been reported. Hydroxypropyl cellulose is an easily extrudable polymer, once its melt viscosity decreases during heating in the 3D printing process.…”

Section: 3d Printingmentioning

confidence: 99%

“…Good results have been shown when it is mixed with EE, in concentrations ranging from 30% to 35% of EE and 5% to 20% of hydroxypropyl cellulose. These filaments had adequate mechanical properties and are easy printability, providing immediate theophylline release after 3D printing as tablets [ 139 ]. Moreover, the addition of plasticizers, like triethyl citrate, was able to decrease the T g of the EE in filaments containing warfarin from 500 µg to 2500 µg, making their printing easier [ 132 ].…”

Section: 3d Printingmentioning

confidence: 99%

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Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

et al. 2021

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Eudragit® polymers are polymethacrylates highly used in pharmaceutics for the development of modified drug delivery systems. They are widely known due to their versatility with regards to chemical composition, solubility, and swelling properties. Moreover, Eudragit polymers are thermoplastic, and their use has been boosted in some production processes, such as hot melt extrusion (HME) and fused deposition modelling 3D printing, among other 3D printing techniques. Therefore, this review covers the studies using Eudragit polymers in the development of drug delivery systems produced by HME and 3D printing techniques over the last 10 years. Eudragit E has been the most used among them, mostly to formulate immediate release systems or as a taste-masker agent. On the other hand, Eudragit RS and Eudragit L100-55 have mainly been used to produce controlled and delayed release systems, respectively. The use of Eudragit polymers in these processes has frequently been devoted to producing solid dispersions and/or to prepare filaments to be 3D printed in different dosage forms. In this review, we highlight the countless possibilities offered by Eudragit polymers in HME and 3D printing, whether alone or in blends, discussing their prominence in the development of innovative modified drug release systems.

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Section: 3d Printingmentioning

confidence: 99%

Section: 3d Printingmentioning

confidence: 99%

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

et al. 2021

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“…They optimized formulations containing theophylline with the addition of sodium starch glycolate to improve the drug dissolution rate. As a result, they printed immediate-release tablets containing up to 60% of API [ 30 ]. Moreover, Hussain et al have proven the effectiveness of sodium starch glycolate and croscarmellose sodium in printlets containing captopril, made from hydroxypropyl cellulose [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

How to Obtain the Maximum Properties Flexibility of 3D Printed Ketoprofen Tablets Using Only One Drug-Loaded Filament?

et al. 2021

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The flexibility of dose and dosage forms makes 3D printing a very interesting tool for personalized medicine, with fused deposition modeling being the most promising and intensively developed method. In our research, we analyzed how various types of disintegrants and drug loading in poly(vinyl alcohol)-based filaments affect their mechanical properties and printability. We also assessed the effect of drug dosage and tablet spatial structure on the dissolution profiles. Given that the development of a method that allows the production of dosage forms with different properties from a single drug-loaded filament is desirable, we developed a method of printing ketoprofen tablets with different dose and dissolution profiles from a single feedstock filament. We optimized the filament preparation by hot-melt extrusion and characterized them. Then, we printed single, bi-, and tri-layer tablets varying with dose, infill density, internal structure, and composition. We analyzed the reproducibility of a spatial structure, phase, and degree of molecular order of ketoprofen in the tablets, and the dissolution profiles. We have printed tablets with immediate- and sustained-release characteristics using one drug-loaded filament, which demonstrates that a single filament can serve as a versatile source for the manufacturing of tablets exhibiting various release characteristics.

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“…With ML's intelligence, 3DP medicines could find the balance between mass manufacturing and extemporaneous preparation, producing bespoke formulations in small batches with validated non-destructive QC. Quality by design (QbD) is another aspect of QC that is promoted by regulatory bodies, including the FDA and the European Medicines Agency (EMA), to improve the understanding of pharmaceutical products and the manufacturing process [50,51]. Certain aspects of the pharmaceutical workflow yield high multicollinearity in data that traditional predictive models find difficult to simulate [52]…”

Section: The Synergistic Power Of ML and Pharmaceutical 3dpmentioning

confidence: 99%

Disrupting 3D printing of medicines with machine learning

Elbadawi

McCoubrey

Gavins

et al. 2021

Trends in Pharmacological Sciences

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Tailoring immediate release FDM 3D printed tablets using a quality by design (QbD) approach

Cited by 38 publications

References 79 publications

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

Eudragit®: A Versatile Family of Polymers for Hot Melt Extrusion and 3D Printing Processes in Pharmaceutics

How to Obtain the Maximum Properties Flexibility of 3D Printed Ketoprofen Tablets Using Only One Drug-Loaded Filament?

Disrupting 3D printing of medicines with machine learning

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