How to Obtain the Maximum Properties Flexibility of 3D Printed Ketoprofen Tablets Using Only One Drug-Loaded Filament?

Abstract

The flexibility of dose and dosage forms makes 3D printing a very interesting tool for personalized medicine, with fused deposition modeling being the most promising and intensively developed method. In our research, we analyzed how various types of disintegrants and drug loading in poly(vinyl alcohol)-based filaments affect their mechanical properties and printability. We also assessed the effect of drug dosage and tablet spatial structure on the dissolution profiles. Given that the development of a method that allows the production of dosage forms with different properties from a single drug-loaded filament is desirable, we developed a method of printing ketoprofen tablets with different dose and dissolution profiles from a single feedstock filament. We optimized the filament preparation by hot-melt extrusion and characterized them. Then, we printed single, bi-, and tri-layer tablets varying with dose, infill density, internal structure, and composition. We analyzed the reproducibility of a spatial structure, phase, and degree of molecular order of ketoprofen in the tablets, and the dissolution profiles. We have printed tablets with immediate- and sustained-release characteristics using one drug-loaded filament, which demonstrates that a single filament can serve as a versatile source for the manufacturing of tablets exhibiting various release characteristics.

Development of Diclofenac Sodium 3D Printed Cylindrical and Tubular-Shaped Tablets through Hot Melt Extrusion and Fused Deposition Modelling Techniques

“…Specifically, the use of PVPP led to an increase in the drug release rate, whereas it decreased for tablets containing CSSNa ( Figure 6 C,D). This is consistent with a previous study showing that CSSNa can indeed be less effective in enhancing the drug release from PVA-based printed tablets within a four-hour dissolution interval when compared to PVPP [ 38 ]. This behaviour can be attributed to differences in the disintegration mechanism between CSSNa and PVPP.…”

Fused Deposition Modeling as a Possible Approach for the Preparation of Orodispersible Tablets

“…We have shown in our previous work that the filaments with Young modulus values ranging from ca. 400 MPa up to more than 2100 MPa are printable in our set-up [22]. The DOM + M filament was 2-times more elastic in comparison to the filament without mannitol.…”

“…The thermograms of raw materials are presented in the Supplementary Materials. We used crospovidone (PVP CL, Kollidon ® CL) as a superdisintegrant in all formulations as we have previously proven its efficiency in 3D printing technology [22].…”

“…In our previous work, we analyzed the effectiveness of a 4% addition of superdisintegrants: sodium starch glycolate, crospovidone, and croscarmellose sodium on the ketoprofen dissolution rate from 3DP tablets. The fastest release was observed for formulations containing crospovidone [22]. The impact of disintegrants has also been analyzed by several other research groups [23][24][25].…”

Personalised 3D-Printed Mucoadhesive Gastroretentive Hydrophilic Matrices for Managing Overactive Bladder (OAB)

“…In addition, at low infill density there is less deposition of the material which results in the formation of more porous tablet leading to faster release of the drug. On the contrary, increase in infill density will increase deposition of the material which will result in less porous tablet with slow release of the drug [ 60 ]. Among all the formulation, the F2 formulation was chosen for in vivo studies as it showed the highest floating capacity with sustained release of the drug.…”