Tail lesions in C<sub>3</sub>H/He mice

Koopman, J. P.; Logt, J. T. M. Van Der; Mullink, J. W. M. A.; Heessen, F. W. A.; Stadhouders, A. M.; Kennis, H. M.; Gulden, W.

doi:10.1258/002367784780891235

Cited by 6 publications

(4 citation statements)

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“…2). The specific combination of histopathological changes observed in the BhϪ͞Ϫ tail, namely ballooning degeneration of the upper stratum spinosum and pallor, together with typical markers of rodent ringtail such as hyperkeratosic parakeratosis, neutrophilic infiltrate, and necrosis, have not been reported previously (26,33). Instead, this unique combination of histomorphological features in BhϪ͞Ϫ tail lesions was similar to descriptions of human skin lesions associated with pellagra, necrolytic migratory erythema (glucagonoma), and acrodermatitis enteropathica (34).…”

Section: Discussionsupporting

confidence: 70%

The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance

Schwartz

Homanics²,

Hoyt³

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

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The papain superfamily member bleomycin hydrolase (Blmh) is a neutral cysteine protease with structural similarity to a 20S proteasome. Bleomycin (BLM), a clinically used glycopeptide anticancer agent, is deaminated in vitro by Blmh. We used gene targeting to generate mice that lack Blmh and demonstrated that Blmh is the sole enzyme required for BLM deamination. Although some Blmh null mice were viable and reproduced, only about 65% of the expected number survived the neonatal period, revealing an important role for Blmh in neonatal survival. Mice lacking Blmh exhibited variably penetrant tail dermatitis that resembled rodent ringtail. The histopathology of the tail dermatitis was similar to skin lesions in humans with pellagra, necrolytic migratory erythema, and acrodermatitis enteropathica. Compared with controls, Blmh null mice were more sensitive to acute BLM lethality and developed pulmonary fibrosis more readily following BLM treatment. Thus, we have established that Blmh is an essential protectant against BLM-induced death and has an important role in neonatal survival and in maintaining epidermal integrity.

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Section: Discussionsupporting

confidence: 70%

The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance

Schwartz

Homanics²,

Hoyt³

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

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“…Here we present the prevalence rates found by use of a screening programme according to the recommendations of FELASA during the period 2000-2003 and compare them with the results of earlier studies from 1981-1984(van der Logt 1986-1993(van der Logt 1996 and rates recently described in other studies (Gilioli et al 1996, Zenner & Regnault 2000, Livingstone & Riley 2003.…”

mentioning

confidence: 58%

“…Table 1 shows the serological screening programme of the International Council of Laboratory Animal Science (ICLAS) reference centre for rodent viruses in Nijmegen on which the data from the 2000-2003 period are based. ELISA was performed as described previously (Koopman et al 1984) using a single serum dilution (1 in 50). Specification of the antigens used for the detection of sialodacryoadenitis/rat coronavirus (SDA/RCV), ectromelia virus, mouse rotavirus (EDIM) and adenovirus have been described by van der Logt (1996).…”

Section: Methodsmentioning

confidence: 99%

Prevalence of naturally occurring viral infections, Mycoplasma pulmonis and Clostridium piliforme in laboratory rodents in Western Europe screened from 2000 to 2003

Ven¹,

Philipse-Bergmann²,

Logt³

2006

Lab Anim

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In this report prevalence rates of rodent viruses in laboratory animals are presented based on routine serological screening of mouse and rat colonies from European institutes. The prevalences found during the period 2000-2003 are compared with those reported for 1981-1984 and 1990-1993. It is shown that some infections were eliminated from laboratory animal colonies (e.g. K-virus and polyomavirus) by taking preventative measures whereas other infections such as mouse hepatitis virus and parvoviruses remained at a high rate. Further decreases in prevalence rates in the last 10 years were found for infections such as pneumonia virus of mice, reovirus type 3, Sendai virus, sialodacryoadenitis/rat coronavirus and Mycoplasma pulmonis. The introduction of new detection methods showed that mouse parvovirus and rat parvovirus, both members of the Parvoviridae family, remain a major threat to laboratory mice and rats. Guinea pig cytomegalovirus and para-influenza virus appeared to be the most prevalent agents among laboratory guinea pigs. The importance of a standardized, up-to-date screening programme is discussed.

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“…Similar lesions have also been related to stress, with different strains of mice showing different sensitivities (Koopman et al 1984).…”

Section: Skin and Appendagesmentioning

confidence: 80%

Mouse

Taylor¹

2012

Background Lesions in Laboratory Animals

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Tail lesions in C₃H/He mice

Cited by 6 publications

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The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance

The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance

Prevalence of naturally occurring viral infections, Mycoplasma pulmonis and Clostridium piliforme in laboratory rodents in Western Europe screened from 2000 to 2003

Mouse

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Tail lesions in C3H/He mice

Cited by 6 publications

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The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance

The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance

Prevalence of naturally occurring viral infections, Mycoplasma pulmonis and Clostridium piliforme in laboratory rodents in Western Europe screened from 2000 to 2003

Mouse

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Tail lesions in C₃H/He mice