Osteoarthritis (OA) is the most prevalent form of arthritis, and the most commonly influenced appendicular joints are knees, hips and fi ngers. (1) The muscle atrophy, cartilage degradation, joint instability and synovial inflammation lead to compromised physical function and pain. (2) Tai Chi involves slow and gentle motions to be particularly suitable to arthritic individuals and is easy to persist since they are costeffective and commonly homebound.As an important part of traditional Chinese exercise (TCE), Tai Chi is a type of mind-body practice that consists of a series of graceful, fl owing movements combined with deep diaphragmatic breathing, relaxation and meditation. (3) With a history of over 400 years, Tai Chi has evolved into various styles and schools that share some basic principles. (4) The non-competitive and self-paced features of Tai Chi make it a unique, feasible way for people to nurture physical and mental well-being. Rigorous and objective evidence supported the mental and physical effi cacy of Tai Chi for patients with lower limb OA. (5)(6)(7)(8) The physical component promotes muscular strength, proprioception, flexibility, postural control, and gait performance, and the mind component improves psychological health and life satisfaction.Application of biopsychosocial model continues to be known as a useful way to understand the physical impairments, psychological distress and social factors for management of OA. (9) According to the World Health Organisation's International Classification of Functioning, Disability, and Health (ICF), body functions, activity and participation are important components of health condition. (10) The ICF core sets for the component "body functions" in OA include a list of categories such as muscle power functions, joint functions, sensation of pain and sleep functions. (10) Even if the domain "infl ammation" is not ICF based, it plays a critical role in the pathophysiological process of OA. The aims of this review are to present a biopsychosocial framework summarizing the health benefi ts of Tai Chi in lower limb OA patients and trying to disentangle the mechanisms that potentially underlie these favourable effects.