Tai Chi for Reducing Dual-task Gait Variability, a Potential Mediator of Fall Risk in Parkinson’s Disease: A Pilot Randomized Controlled Trial

Vergara‐Diaz, Gloria; Osypiuk, Kamila; Hausdorff, Jeffrey M.; Bonato, Paolo; Gow, Brian J.; Miranda, Jose; Sudarsky, Lewis; Tarsy, Daniel; Fox, Michael; Gardiner, Paula; Thomas, Cathi A.; Macklin, Eric A.; Wayne, Peter M.

doi:10.1177/2164956118775385

Cited by 47 publications

(80 citation statements)

References 49 publications

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“…Fifteen articles [25,26,28,29,31,[33][34][35][36][38][39][40][41][42]46] evaluated the effects of physical and mental exercise on PD motor function (Table 1). Among them, 13 articles [25,26,28,29,[34][35][36][38][39][40][41][42]46] used bradykinesia items in the motor section of the Unified Parkinson's Disease Rating Scale (UPDRSIII) to evaluate the effect of patients' motor function, and the remaining two used UPDRS [31] and MDRSPD [33]. An asymmetrical funnel plot was presented.…”

Section: Updrs (Unified Parkinson's Disease Rating Scal) Rating Resultsmentioning

confidence: 99%

“…Finally, after evaluating the full text of the remaining studies, we included 22 clinical trials (RCT+CCT). Nine studies were published in English [25][26][27]31,[34][35][36]38,39], and 13 in Chinese [28][29][30]32,33,37,[40][41][42][43][44][45][46], The research selection process is shown in Figure 1 and Figure S1. Our search strategy identified a total of 799 related references.…”

Section: Literature Searchmentioning

confidence: 99%

“…The control group included various interventions, such as stretching and conditioning exercises, walking, and health education. Only three studies [26,31,36] used a waitlist control to treat each exercise time for 60 min. Table 2 shows the Pedro literature quality assessment scores that met study conditions.…”

Section: Study Characteristicsmentioning

confidence: 99%

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The Impact of Mind-Body Exercises on Motor Function, Depressive Symptoms, and Quality of Life in Parkinson’s Disease: A Systematic Review and Meta-Analysis

Jin

Wang

Liu

et al. 2019

IJERPH

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Purpose: To systematically evaluate the effects of mind-body exercises (Tai Chi, Yoga, and Health Qigong) on motor function (UPDRS, Timed-Up-and-Go, Balance), depressive symptoms, and quality of life (QoL) of Parkinson’s patients (PD). Methods: Through computer system search and manual retrieval, PubMed, Web of Science, The Cochrane Library, CNKI, Wanfang Database, and CQVIP were used. Articles were retrieved up to the published date of June 30, 2019. Following the Cochrane Collaboration System Evaluation Manual (version 5.1.0), two researchers independently evaluated the quality and bias risk of each article, including 22 evaluated articles. The Pedro quality score of 6 points or more was found for 86% (19/22) of these studies, of which 21 were randomized controlled trials with a total of 1199 subjects; and the trial intervention time ranged from 4 to 24 weeks. Interventions in the control group included no-intervention controls, placebo, waiting-lists, routine care, and non-sports controls. Meta-analysis was performed on the literature using RevMan 5.3 statistical software, and heterogeneity analysis was performed using Stata 14.0 software. Results: (1) Mind-body exercises significantly improved motor function in PD patients, including UPDRS (SMD = −0.61, p < 0.001), TUG (SMD = −1.47, p < 0.001) and balance function (SMD = 0.79, p < 0.001). (2) Mind-body exercises also had significant effects on depression (SMD = −1.61, p = 0.002) and QoL (SMD = 0.66, p < 0.001). (3) Among the indicators, UPDRS (I2 = 81%) and depression (I2 = 91%) had higher heterogeneity; according to the results of the separate combined effect sizes of TUG (I2 = 29%), Balance (I2 = 16%) and QoL (I2 = 35%), it shows that the heterogeneity is small; (4) After meta-regression analysis of the age limit and other possible confounding factors, further subgroup analysis showed that the reason for the heterogeneity of UPDRS motor function may be related to the sex of PD patients and severity of the disease; the outcome of depression was heterogeneous. The reason for this may be the use of specific drugs in the experiment and the duration of intervention in the trial. Conclusion: (1) Mind-body exercises were found to have significant improvements in motor function, depressive symptoms, and quality of life in patients with Parkinson’s disease, and can be used as an effective method for clinical exercise intervention in PD patients. (2) Future clinical intervention programs for PD patients need to fully consider specific factors such as gender, severity of disease, specific drug use, and intervention cycle to effectively control heterogeneity factors, so that the clinical exercise intervention program for PD patients is objective, scientific, and effective.

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Section: Updrs (Unified Parkinson's Disease Rating Scal) Rating Resultsmentioning

confidence: 99%

Section: Literature Searchmentioning

confidence: 99%

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The Impact of Mind-Body Exercises on Motor Function, Depressive Symptoms, and Quality of Life in Parkinson’s Disease: A Systematic Review and Meta-Analysis

Jin

Wang

Liu

et al. 2019

IJERPH

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“…No início, a DA compromete a formação hipocampal, memória de curto prazo, com posterior expansão para outras áreas, atingindo a orientação, a atenção, linguagem, capacidade para resolver problemas, habilidades motoras para executar as atividades da vida diária (AVDs), inclusive de higiene pessoal, passando, possivelmente, por todos os estágios, o que exige altos gastos financeiros da família e/ou do poder público 2 . Sabe-se que esta doença compromete também o controle postural, a marcha, a manipulação de objetos, entre outras atividades simples de uso diário, principalmente quando realizadas simultaneamente com uma tarefa cognitiva -Dupla Tarefa (DT) 5 .…”

Section: Saúde E Pesqui 2019 Jan-abr; 12(1): 197-202 -E-issn 2176-9206unclassified

Efeitos Da Prática De Exercício De Dupla Tarefa Em Idosos Com Doença De Alzheimer: Revisão Sistemática

et al. 2019

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O presente estudo objetivou revisar de forma sistemática a literatura atual para sumarizar o efeito de intervenções com dupla tarefa sobre sintomas da Doença de Alzheimer. Trata-se de uma revisão sistemática da literatura. Foram utilizadas as bases de dados PubMed, Scielo e Lilacs. Incluíram-se estudos em idosos com Doença de Alzheimer, em tratamento por meio da dupla tarefa. Os quatro estudos incluídos mostraram que as intervenções duraram de 04 a 12 meses, com frequência semanal de duas a três sessões de no mínimo 60 minutos. O tamanho da amostra variou de 10 a 210 idosos. Um dos estudos apresentou a dupla tarefa com enfoque no exercício funcional. Outros dois apresentaram a dupla tarefa junto de exercícios aeróbios, força, resistência, equilíbrio e coordenação motora. Por fim, o quarto grupo utilizou apenas os exercícios de dupla tarefa. Os estudos têm comprovado que o exercício de dupla tarefa pode amenizar e controlar as perdas motoras e cognitivas ocasionadas por esta doença.

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“…However, a critical appraisal of available evidence also reveals that despite the high number of studies in the eld, there is a paucity of comparative analyses of distinct intervention modalities in randomized controlled studies with prespeci ed outcome parameters (24,25). Currently, machine-supported or augmented, professionally supervised resistance training is a well-established, reliable and effective exercise intervention strategy to regain muscle mass and strength in the elderly (22,(26)(27)(28) and can be considered gold standard. However, real world feasibility and sustainability of such an intervention is limited by costs, accessibility, adherence, and the motivation of untrained seniors to familiarize with this type of exercise modality.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of simple exercise interventions for men with osteoporosis – a prospective randomized controlled trial

Genest¹,

Lindström²,

Scherer³

et al. 2020

Preprint

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Background: Aging is associated with progressive loss of musculoskeletal performance. Exercise interventions can improve physical function in the elderly but there is a paucity of comparative assessments in order to understand what specific goals can be achieved particularly with less demanding exercise interventions readily accessible for untrained men. Methods: Prospective randomized, controlled, single center trial to compare efficacy and feasibility of four distinct exercise interventions for 6 months in men at risk for osteoporosis aged 65-90 years. Primary endpoint was change in isometric one repetition maximum force trunk strength for extension (TSE) and flexion (TSF) compared to baseline, secondary endpoints covered key parameters of geriatric functional assessment, including Handgrip Strength (HS), Chair-Rise-Test (CRT) Usual Gait Speed (UGS) and Timed-Up-and-Go (TUG).Results: Altogether 47 men (mean age 77 +/-6.1years) were randomized to Resistance Training (RT, n=11), Whole Body Vibration Exercise (WBV, n=13), Qi Gong (QG, n=10) and wearing a Spinal Orthosis (SO, n=13). RT lead to significant improvements for TSE (p=0.009) and TSF (p=0.013). Vibration exercise caused sign. Progress in TSE (p=0.014) and CRT (p=0.005), the Spinal Orthosis improved CRT (p=0.003) and Gait Speed (p=0.027), while the QG Group did not attain any sig. developments. Subgroup analyses revealed most pronounced musculoskeletal progress in vulnerable patients (age ≥80years, pre-sarcopenia, multimorbidity ≥3chronic diseases). Irrespective of the type of exercise, participants ≥80years experienced significant gain in TSE (p=0.029) and CRT (p=0.017). Presarcopenic subjects (Skeletal muscle Index (SMI) ≤10.75 kg/m²) improved in TSE (p=0.003), CRT (p=0.001) and UGS (p=0.016). Multimorbid participants achieved sig. gains in TSE (p<0.001), TSF (p=0.002), UGS (p=0.036) and HS (p=0.046).Conclusions: Simple exercise interventions are feasible in elderly men with specific efficacy, i.e. improvements are attained in those tasks addressed with the training. Consequently, exercise strategies in elderly men should comprise multiple modalities to comprehensively cover various deficits. For vulnerable patients, any simple training appears beneficial.

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Tai Chi for Reducing Dual-task Gait Variability, a Potential Mediator of Fall Risk in Parkinson’s Disease: A Pilot Randomized Controlled Trial

Cited by 47 publications

References 49 publications

The Impact of Mind-Body Exercises on Motor Function, Depressive Symptoms, and Quality of Life in Parkinson’s Disease: A Systematic Review and Meta-Analysis

The Impact of Mind-Body Exercises on Motor Function, Depressive Symptoms, and Quality of Life in Parkinson’s Disease: A Systematic Review and Meta-Analysis

Efeitos Da Prática De Exercício De Dupla Tarefa Em Idosos Com Doença De Alzheimer: Revisão Sistemática

Efficacy and safety of simple exercise interventions for men with osteoporosis – a prospective randomized controlled trial

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