Tai Chi Chuan Exercise Decreases A1C Levels Along With Increase of Regulatory T-Cells and Decrease of Cytotoxic T-Cell Population in Type 2 Diabetic Patients

Yeh, Shu-Hui; Chuang, Hai‐Hua; Lin, Li‐Wei; Hsiao, Chiu‐Yueh; Wang, Pei‐Wen; Yang, Kuender D.

doi:10.2337/dc06-1507

Cited by 46 publications

(34 citation statements)

References 21 publications

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“…There was no mention of the medications taken by these subjects either. Though the statistically significant HbA 1c improvement reported by Yeh et al's study [16] was statistically significant, it was smaller than effects seen with other forms of robust exercise, and the absence of a control group precludes drawing definitive conclusions from this trial. The difference in results compared to our study may be due to the lack of a control group, the different TC style utilised, the increased frequency of training (3 versus 2 days/week), or the subject characteristics and diabetes duration.…”

Section: Discussionmentioning

confidence: 42%

“…Another study examining low-to-moderate intensity exercise in patients aged over 65 years with T2DM also found no change in HbA 1c after 16 weeks of aerobic, strength and stretching exercises, for 80 min, three times a week [15]. However a recent non-controlled study observed an absolute decrease in HbA 1c of 0.46% after a 12-week, thrice-weekly TC program, where the Cheng style 37 Forms was practiced 1 h per class [16]. Subjects in this study were younger, and did not have as long-standing diabetes as our cohort.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Tai Chi on glucose homeostasis and insulin sensitivity in older adults with type 2 diabetes: a randomised double-blind sham-exercise-controlled trial

et al. 2007

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Background a large proportion of adults with type 2 diabetes remain sedentary despite evidence of benefits from exercise for type 2 diabetes. Simplified Yang Tai Chi has been shown in one study to have no effect on insulin sensitivity in older adults. However, a modified Tai Chi form, Tai Chi for Diabetes (TCD) has recently been composed, claiming to improve diabetes control. Methods subjects were randomised to Tai Chi or sham exercise, twice a week for 16 weeks. Primary outcomes were insulin resistance 72 h post-exercise (HOMA2-IR), and long-term glucose control (HbA 1c ). Results thirty-eight subjects (65 ± 7.8 years, 79% women) were enrolled. Baseline BMI was 32.2 ± 6.3 kg/m 2 , 84% had osteoarthritis, 76% hypertension, and 34% cardiac disease. There was one dropout, no adverse events, and median compliance was 100 (0 − 100)%. There were no effects of time or group assignment on insulin resistance or HbA 1c ( −0.07 ± 0.4% Tai Chi versus 0.12 ± 0.3% Sham; P = 0.13) at 16 weeks. Improvement in HbA 1c was related to decreased body fat (r = 0.484, P = 0.004) and improvement in insulin resistance was related to decreased body fat (r = 0.37, P = 0.03) and central adiposity (r = 0.38, P = 0.02), as well as increased fat-free mass (r = −0.46, P = 0.005). Conclusions TCD did not improve glucose homeostasis or insulin sensitivity measured 72 h after the last bout of exercise. More intense forms of Tai Chi may be required to produce the body composition changes associated with metabolic benefits in type 2 diabetes.

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Section: Discussionmentioning

confidence: 42%

Section: Discussionmentioning

confidence: 99%

Effects of Tai Chi on glucose homeostasis and insulin sensitivity in older adults with type 2 diabetes: a randomised double-blind sham-exercise-controlled trial

et al. 2007

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“…The low-to-moderate intensity of TC exercise is expected to improve glucose metabolism, resulting in lower levels of HbA1c and insulin resistance. 17 Previous studies looking at the effects of TC exercise on glucose control in diabetic patients have produced conflicting results. The findings of several studies support the beneficial effects of TC exercise on glucose control, 20,23 but a randomized study with the TCD program found no significant improvement on either glucose homeostasis or insulin sensitivity.…”

Section: Discussionmentioning

confidence: 98%

“…A power analysis 16 revealed that a sample size of 52 was required based on effect size d = 0.7, a = 0.05 (one-side probability), and power (1 -b) = 0.80. The effect size was calculated based on the study by Yeh et al 17 to examine the effect of TC exercise on changes in HbA1c with a one-group design (mean difference score 0.8, standard deviation = 1.2).…”

Section: Study Populationmentioning

confidence: 99%

Effects of Tai Chi Exercise on Glucose Control, Neuropathy Scores, Balance, and Quality of Life in Patients with Type 2 Diabetes and Neuropathy

Ahn

Song

2012

The Journal of Alternative and Complementary Medicine

111

150

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Purpose: The aim of this study was to determine the effects of Tai Chi exercise on glucose control, neuropathy scores, balance, and quality of life in patients with type 2 diabetes and neuropathy. Methods: A pretest-posttest design with a nonequivalent control group was utilized to recruit 59 diabetic patients with neuropathy from an outpatient clinic of a university hospital. A standardized Tai Chi for diabetes program was provided, which comprised 1 hour of Tai Chi per session, twice a week for 12 weeks. Outcome variables were fasting blood glucose and glycosylated hemoglobin for glucose control, the Semmes-Weinstein 10-g monofilament examination scores and total symptom scores for neuropathy, single leg stance for balance, and the Korean version of the SF-36v2 for quality of life. Thirty-nine patients completed the posttest measures after the 12-week Tai Chi intervention, giving a 34% dropout rate. Results: The mean age of the participants was 64 years, and they had been diagnosed with type 2 diabetes for more than 12 years. The status was significantly better for the participants in the Tai Chi group (n = 20) than for their control (i.e., nonintervention) counterparts (n = 19) in terms of total symptom scores, glucose control, balance, and quality of life. Conclusion: Tai Chi improved glucose control, balance, neuropathic symptoms, and some dimensions of quality of life in diabetic patients with neuropathy. Further studies with larger samples and long-term follow-up are needed to confirm the effects of Tai Chi on the management of diabetic neuropathy, which may have an impact on fall prevention in this population.

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“…One study reported that 12 weeks of light intensity tai chi exercises enhanced regulatory T cell function and anti-inflammatory cytokine production (45). Another study showed that progressive, moderate intensity exercise has a beneficial effect on natural killer T cell numbers, up-regulates T-helper cell mediated immune functions, and reduces the risk of infection and autoimmune disease in elderly people (46).…”

Section: Discussionmentioning

confidence: 99%

Immune responses following McKenzie lumbar spine exercise in individuals with acute low back pain: A preliminary study

Al‐Obaidi

Mahmoud

2014

AMA

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Objective. This study explores the immune responses following 4 weeks of McKenzie lumbar spine exercise in individuals with acute low back pain (ALBP). Patients and methods. Fifteen patients with ALBP and 15 healthy individuals volunteered in this study. Ten ml of peripheral blood were obtained from each patient before and after exercise sessions, and from healthy individuals at the beginning of the study.

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Tai Chi Chuan Exercise Decreases A1C Levels Along With Increase of Regulatory T-Cells and Decrease of Cytotoxic T-Cell Population in Type 2 Diabetic Patients

Cited by 46 publications

References 21 publications

Effects of Tai Chi on glucose homeostasis and insulin sensitivity in older adults with type 2 diabetes: a randomised double-blind sham-exercise-controlled trial

Effects of Tai Chi on glucose homeostasis and insulin sensitivity in older adults with type 2 diabetes: a randomised double-blind sham-exercise-controlled trial

Effects of Tai Chi Exercise on Glucose Control, Neuropathy Scores, Balance, and Quality of Life in Patients with Type 2 Diabetes and Neuropathy

Immune responses following McKenzie lumbar spine exercise in individuals with acute low back pain: A preliminary study

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