Taenia crassiceps antigens induce a Th2 immune response and attenuate injuries experimentally induced by neurotoxoplasmosis in BALB/c mice

Souza, Amanda Juliana Soaris de; Milhomem, Anália Cirqueira; Rezende, Hanstter Hallison Alves; Matos-Silva, Hidelberto; Vinaud, Marina Clare; Oliveira, Milton Adriano Pelli de; Castro, Ana Maria de; Lino-Júnior, Ruy S.

doi:10.1016/j.parint.2017.10.001

Cited by 1 publication

(2 citation statements)

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“…Indeed, the ability of helminth products to modulate cytokine profile and control histological inflammation have been demonstrated in inflammatory diseases and even in T gondii infection. In a neurotoxoplasmosis model, the treatment with T crassiceps antigens decreased IFN‐γ and IL‐10 levels and enhanced IL‐4 production leading to attenuated brain injuries in treated BALB/c mice 43 . Intestinal pathology suppression caused by drug‐induced colitis was reduced in mice treated with Ancylostoma caninum excretory/secretory products 95 or Nippostrongylus brasiliensis extracellular vesicles, 38 and this effect was associated with high levels of IL‐10 and downregulation of the proinflammatory cytokines IFN‐γ, IL‐17 and IL‐6.…”

Section: Discussionmentioning

confidence: 99%

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Beneficial effects of Strongyloides venezuelensis antigen extract in acute experimental toxoplasmosis

Araújo

Cariaco

Almeida

et al. 2020

Parasite Immunology

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Background Toxoplasma gondii is a protozoan with worldwide distribution and triggers a strong Th1 immune response in infected susceptible hosts. On the contrary, most helminth infections are characterized by Th2 immune response and the use of helminth‐derived antigens to regulate immune response in inflammatory disorders has been broadly investigated. Objectives The aim of this study was to investigate whether treatment with Strongyloides venezuelensis antigen extract (SvAg) would alter immune response against T gondii. Methods C57BL/6 mice were orally infected with T gondii and treated with SvAg, and parasitological, histological and immunological parameters were investigated. Results It was observed that SvAg treatment improved survival rates of T gondii‐infected mice. At day 7 post‐infection, the parasite load was lower in the lung and small intestine of infected SvAg‐treated mice than untreated infected mice. Remarkably, SvAg‐treated mice infected with T gondii presented reduced inflammatory lesions in the small intestine than infected untreated mice and decreased intestinal and systemic levels of IFN‐γ, TNF‐α and IL‐6. In contrast, SvAg treatment increased T gondii‐specific IgA serum levels in infected mice. Conclusions S venezuelensis antigen extract has anti‐parasitic and anti‐inflammatory properties during T gondii infection suggesting as a possible alternative to parasite and inflammation control.

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Section: Discussionmentioning

confidence: 99%

“…Furthermore, helminths have the ability to downregulate Th1 response to microbial pathogens in coinfected hosts 28‐33 . Beyond helminth infection itself, treatment with helminth‐derived antigens regulates immune response in inflammatory disorders, 34‐40 including infectious diseases 41‐43 …”

Section: Introductionmentioning

confidence: 99%