Tadalafil 5 mg Once Daily Improves Lower Urinary Tract Symptoms and Erectile Dysfunction: A Systematic Review and Meta‐analysis

Wang, Yilin; Bao, Yiping; Liu, Jie; Duan, Lijun; Cui, Yuanshan

doi:10.1111/luts.12144

Cited by 37 publications

(24 citation statements)

References 45 publications

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“…According to the resistance of the organism and adequate antimicrobial therapy, the infection recovers relatively quickly. [3][4][5][6][7][8][9][10][11][12] In this study, there was no significant difference between patients of the first and second group regarding the number of episodes of symptomatic urinary infections per check-up. There was a (statistically significant) difference between the first and second groups when it came to the time of diagnosing these complications.…”

Section: Discussionmentioning

confidence: 85%

“…Subjective data on the reduction of bladder volume before and after voiding is more significant in case when is RUT larger. [3][4][5][6][7][8][9][10] In patients from the first group, the average RU value was highest at the first check-up and the lowest at the fifth check-up. There was no statistically significant difference between the checkups compared to the average RU in patients of the first group, but there was statistically significant difference in the average value of the RU in patients of the second group.…”

Section: Discussionmentioning

confidence: 99%

“…Haematuria did not occur in large numbers because the patients regularly used prescribed medication therapy with the proposed diet, thus reducing the possibility of congestion of adenoma and occurrence of significant hematuria. [4][5][6][7][8][9][10][11][12][13][14] Bladder wall thickening, occurrence of trabeculae and diverticulum are changes in the bladder that occur due to obstruction. In the analysis presented here, the occurrence of complications in the form of thickening of the detrusor was monitored.…”

Section: Discussionmentioning

confidence: 99%

“…Detrusor thickening was verified if the ultrasonographically measured detrusor thickness was over 5 mm. [4][5][6][7][8][9][10][11][12][13][14] Diverticulum of the bladder is a common complication in the late stage of BPH and it is caused by loosening of the stretched wall. In one study of 300 patients, diverticulum was found in 10 (3.4 %) patients and secondary diverticulosis in 38 (12.6 %) patients.…”

Section: Discussionmentioning

confidence: 99%

“…The patients in the present study did not have an AUR and/or RU over 300 mL, so this complication did not develop. [6][7][8][9][10][11][12][13][14][15][16][17] AUR is a very common complication of BPH. It is caused by a conglomerate: sphincter spasm, detrusor hyperdistension, congestion and prostate infarction.…”

Section: Discussionmentioning

confidence: 99%

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Frequency of common complications during treatment of patients with benign prostate hyperplasia

Krickovic¹,

Simatović²,

Lukić³

et al. 2020

Scripta Medica

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Background/Aim: Benign prostatic hyperplasia (BPH) is a very common disease in older men. BPH involves the presence of signs of hyperplasia of the stromal and epithelial elements in the prostate with consequent enlargement of its volume. The aim of this study is to analyse the frequency of typical complications in the treatment of patients with benign prostatic hyperplasia and the effect of medicamentous treatment. Method: Patients diagnosed BPH were included in the prospective, one-year study. They were divided into 2 groups. The first group (30 patients) consisted of those ones, whose prostate volume was equal to or over 50 cm 3 , while and the second group (30 patients) comprised the subjects with prostate volume less than 50 cm 3 . The complications of BHP analysed are residual urine (RU), symptomatic urinary infection, haematuria, thickening of the detrusor wall, diverticulum in the bladder, ureterohydronephrosis, renal failure, bladder stone and acute urinary retention (AUR). Results: The majority of patients in both groups were aged 60-69. There was a statistically significant difference in the average value of RU between the groups at the first, second and fifth check-ups (p < 0.05), as well as the complication of symptomatic urinary infection, since the same occurred earlier in the first group than in the second group (p < 0.05). There was no statistically significant difference in complications: haematuria, detrusor wall thickening and diverticulum (p > 0.05). Complications: ureterohydronephrosis, renal failure, bladder stone, and AUR were not diagnosed in patients in either group. Conclusion: Relevant medical therapy leads to a reduction of RU and reduces the risk of complications caused by its presence. Other complications of BPH were rare or absent in both groups, suggesting that appropriate and timely applied medical therapy affects the course of BPH and reduces the risk of complications and the need for surgical treatment. Benefit from medicamentous therapy is equally represented in both analysed groups of patients.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Frequency of common complications during treatment of patients with benign prostate hyperplasia

Krickovic¹,

Simatović²,

Lukić³

et al. 2020

Scripta Medica

View full text Add to dashboard Cite

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Add‐on effects of tadalafil in tamsulosin‐treated patients with small benign prostatic enlargement: A randomized, placebo‐controlled, double‐blind, crossover study

Negoro

Goto

Akamatsu

et al. 2019

Neurourology and Urodynamics

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Aim: To assess the add-on effects of tadalafil in patients with a relatively small benign prostatic enlargement (BPE) treated with tamsulosin. Methods: From September 2014 to July 2018, we prospectively studied patients (aged 50 years or more) attending our hospital who had received tamsulosin for small BPE (20-40 mL) for 4 weeks at least and still had residual lower urinary tract symptoms (LUTS) with total International Prostate Symptom Scores (IPSS) of at least 8 and IPSS-quality of life scores at least 3. We randomized eligible patients into two groups: one of which received tadalafil 5 mg once daily for 6 weeks, followed by placebo for 6 weeks, and the other of which received placebo followed by tadalafil in the same manner. The patients were reviewed at our outpatient clinic after 2, 6, 8, and 12 weeks.Results: There were 13 patients in the tadalafil-placebo and 13 in the placebotadalafil group. Their median ages (range) were 70 (65-85) and 73 (50-80) years, prostatic volumes (median) 30.0 (22.0-39.7) and 32.0 (20.1-39.5) mL, and total IPSS (median) 17 (10-27) and 16 (10-24), respectively. The primary endpoints, namely mean changes of total IPSS from baseline, were 1.85 on placebo and −3.42 on tadalafil; this difference is statistically significant (difference: −1.57; 95% confidence interval: −3.00, −0.69; P = .032). We encountered no adverse effects. Conclusions: Add-on of tadalafil for symptomatic patients with small BPE treated with tamsulosin appears to be effective and safe. K E Y W O R D S α-blocker, lower urinary tract symptoms, RCT, tadalafil

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Lower urinary tract symptoms: initial management in men

Brown

Burden

2021

Prescriber

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Tadalafil 5 mg Once Daily Improves Lower Urinary Tract Symptoms and Erectile Dysfunction: A Systematic Review and Meta‐analysis

Abstract: This meta-analysis indicates that tadalafil 5 mg once-daily to be an effective treatment for LUTS and ED with a low occurrence of side effects.

Cited by 37 publications

References 45 publications

Frequency of common complications during treatment of patients with benign prostate hyperplasia

Frequency of common complications during treatment of patients with benign prostate hyperplasia

Add‐on effects of tadalafil in tamsulosin‐treated patients with small benign prostatic enlargement: A randomized, placebo‐controlled, double‐blind, crossover study

Lower urinary tract symptoms: initial management in men

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