Tactile Stimulation Improves Cognition, Motor, and Anxiety-Like Behaviours and Attenuates the AD Pathology in Adult APP ^{NL-G-F/NL-G-F} mice

Abstract

Alzheimer Disease (AD) is one of the largest health crises in the world. There are, however, limited but expensive pharmaceutical interventions to treat AD and most of the treatment options are not for cure or prevention, but to slow down the progression of the disease. The aim of this study was to examine the effect of tactile stimulation on AD-like symptoms and pathology in APPNL-G-F/NL-G-F mice, a mouse model of AD. The results show that tactile stimulation improves the AD-like symptoms on tests of cognition, motor, and anxiety-like behaviours and these improvements are associated with reduced AD pathology in APP mice.

Tactile discrimination as a diagnostic indicator of cognitive decline in patients with mild cognitive impairment: A narrative review

“…Moreover, neonatal tactile stimulation improved cognitive, motor skills, and anxiety-like symptoms in both pregnancy-stressed and non-stressed adult APP mice, changes that were associated with reduced Aβ plaque formation [ 49 ]. The application of TS in adult APP mice reduced AD-like behavioral symptoms and pathology in adult APP mice [ 50 ].…”