Tacrolimus ointment in the treatment of occupationally induced chronic hand dermatitis

Schliemann, Sibylle; Kelterer, D.; Bauer, Andrea; John, Swen Malte; Skudlik, Christoph; Schindera, Ingo; Wehrmann, Wolfgang; Elsner, Peter

doi:10.1111/j.1600-0536.2007.01314.x

Cited by 49 publications

(37 citation statements)

References 37 publications

(37 reference statements)

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“…Additionally, a small fraction of chronic hand eczema patients experience burning or stinging, erythema, or worsening under treatment [48]. Concerns over potential photo-carcinogenicity have been raised because of established effects in systemic therapy in organ transplant recipients and animal data on topical preparations.…”

Section: Topical Calcineurin Inhibitors (Tcis)mentioning

confidence: 98%

“…Their most valuable advantage is their safety over long-term usage, without the induction of atrophy or interference with barrier repair. Their anti-inflammatory potency has been approximated to that of lower mid-strength corticosteroids, such as 0.1 % hydrocortisone butyrate or 0.1 % betamethasone-17-valerate [48,49]. There are several studies in chronic hand eczema [48,50] (reviewed in [51]) where TCIs showed good therapeutic effects worthy of further study in large RCTs.…”

Section: Topical Calcineurin Inhibitors (Tcis)mentioning

confidence: 98%

“…Their anti-inflammatory potency has been approximated to that of lower mid-strength corticosteroids, such as 0.1 % hydrocortisone butyrate or 0.1 % betamethasone-17-valerate [48,49]. There are several studies in chronic hand eczema [48,50] (reviewed in [51]) where TCIs showed good therapeutic effects worthy of further study in large RCTs. As TCIs may not penetrate well through hyperkeratosis, in some of the studies they were applied under occlusion; for example, twice daily with overnight occlusion [52].…”

Section: Topical Calcineurin Inhibitors (Tcis)mentioning

confidence: 98%

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Hand Dermatitis: A Review of Clinical Features, Prevention and Treatment

2015

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Hand dermatitis is a socially significant health problem. This review provides a discussion on the clinical features and patterns as well as the differential diagnosis of hand dermatitis, because these are essential for proper diagnosis in clinical practice. The morphology, however, is poorly related to the etiology in chronic cases. In all cases of chronic hand dermatitis, a full diagnostic examination should be undertaken and the etiology should be clarified and addressed in the treatment concept, instead of just moving directly from a morphological diagnosis to therapy. Preventive measures should be included in the treatment concept according to etiology. A stepwise approach for escalating therapy is advised, including basic topical therapy, topical corticosteroids, calcineurin inhibitors, as well as phototherapy and systemic therapy with corticosteroids, alitretinoin, cyclosporine, methotrexate, azathioprine, and others.

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Section: Topical Calcineurin Inhibitors (Tcis)mentioning

confidence: 98%

Section: Topical Calcineurin Inhibitors (Tcis)mentioning

confidence: 98%

Section: Topical Calcineurin Inhibitors (Tcis)mentioning

confidence: 98%

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Hand Dermatitis: A Review of Clinical Features, Prevention and Treatment

2015

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“…Die Kortikosteroidauswahl ist ansonsten zunächst abhän-gig vom aktuellen Befund, einer prästa-tionären Anwendungsphase und erfolgt gemäß den Empfehlungen der Leitlinie Management von Handekzemen [19]. Als Ersatz stehen bevorzugt Calcineurininhibitoren [25], in Fällen einer zusätzlichen Psoriasis auch Calcipotriol zur Verfü-gung. Als wesentlicher Nachteil von Calcineurininhibitoren wird der geforderte Verzicht einer adjuvanten Phototherapie erachtet.…”

Section: Therapieunclassified

Rehabilitation bei Berufsdermatosen

2010

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In recent years, the number of reports of suspicions of occupational diseases, received by the public statutory employer's liability insurance bodies, has remained constant. The recognition of occupational diseases under number 5101 BKV, however, has decreased considerably. This is more than likely due to improved prevention management concepts by the public statutory employer's liability insurance bodies. Nevertheless there are still severe occupational skin diseases that are resistant to or relapse under therapy, thus threatening discontinuation of the occupation. For these cases, an interdisciplinary inpatient treatment as a tertiary individual prevention measure was introduced. This consists of a three-week inpatient period followed by a three-week outpatient sick leave for further stabilization of the skin condition. During the inpatient stay intensive dermatological diagnosis and treatment are accompanied by in-depth health education seminars and psychological interventions. The selection of individually suitable skin protection measures and their practical trial in a workplace simulation model with an ergotherapist are of particular importance. Evaluations of this program showed that two-thirds of the participants with the defined risk of having to give up their occupation were able to continue with their occupation on a long-term basis.

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“…Seine antiinflammatorische Wirkung wird den der moderat potenten topischen Steroide gleichgestellt [13]. Erst kürzlich wurde in einer prospektiven, of fenen, multizentrischen Studie mit 29 Pa tienten, die an einem milden bis modera ten beruflich bedingten Handekzem lit ten, gezeigt, dass die lokale Anwendung von Tacrolimus bei 44% der Patienten zu einer Heilung führte [14]. Tacrolimus wurde dabei in einer Konzentration von 0,1% über 4 Wochen 2mal täglich ange wandt.…”

Section: Ciclosporin Als Systemische Tacrolimus Als Topische Therapiunclassified

New and rarley used treatment options for refractory hand eczema

et al. 2008

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Hand eczema (HE) is one of the most frequent skin diseases. HE has a wide spectrum, with variable etiology, severity, and morphology. It often displays a chronically relapsing course with a poor prognosis, and has a high impact on the quality of life. Although different treatment options exist, the management of patients with chronic HE is often unsatisfactory. We highlight new and rarely used approaches to treat chronic HE uncluding local UVA-1-phototherapy, retinoids including the new oral retinoid alitretinoin, and calcineurin inhibitors.

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Tacrolimus ointment in the treatment of occupationally induced chronic hand dermatitis

Abstract: Topical tacrolimus might be an efficacious treatment option for chronic OHD. Blinded and randomized controlled studies are necessary to confirm the results of this pilot study.

Cited by 49 publications

References 37 publications

Hand Dermatitis: A Review of Clinical Features, Prevention and Treatment

Hand Dermatitis: A Review of Clinical Features, Prevention and Treatment

Rehabilitation bei Berufsdermatosen

New and rarley used treatment options for refractory hand eczema

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