Tacrolimus-Induced Rosacea-Like Dermatitis: A Clinical Analysis of 16 Cases Associated with Tacrolimus Ointment Application

Abstract

Background: Recently, reports have indicated that the continuous use of topical calcineurin inhibitors such as tacrolimus may induce rosacea-like dermatitis (RD). Objective and Methods: To assess clinical features of RD associated with tacrolimus, 44 cases of patients diagnosed with RD between 2005 and 2010 at our hospital were retrospectively reviewed. Results: In total, 22 cases were caused by topical steroid use, 8 by topical tacrolimus use, and 8 by consecutive treatment with topical steroids and tacrolimus. Clinical presentation was basically similar among the 3 groups, although the nose was less frequently affected and pustules were rarely observed in the latter 2 sets of cases. Demodex mites were often found in smears of skin lesions from patients with RD caused by steroids and tacrolimus. Treatment with topical metronidazole was effective in most RD patients. Conclusion: Topical tacrolimus is becoming an important cause of RD along with topical steroids.

Mutant HSP70 Reverses Autoimmune Depigmentation in Vitiligo

“…Ablation of autoimmunity is the most commonly prescribed approach, through the use of systemic or topical corticosteroids or topical application of calcineurin inhibitors (tacrolimus, pimecrolimus), often supplemented by ultraviolet (UV) phototherapy (3). Treatment responses are frequently inadequate, and complications from steroid therapy or calcineurin inhibition can occur (4). Melanocyte-protective pseudocatalase treatment does not appear to offer superior efficacy over UV treatment alone (5).…”

Neutrophilic Sebaceous Adenitis With Intralobular Demodex Mites

“…5 Although often seen in nondiseased follicles, a pathogenic role has been implicated in a number of skin conditions where Demodex mites are found in greater numbers (demodicosis). 16,17 Two Demodex mite species are known to occupy pilosebaceous follicles in humans. 16,17 Two Demodex mite species are known to occupy pilosebaceous follicles in humans.…”

Cutaneous and ocular forms of rosacea

“…Rosacea-szerű bőrtünetek gyógyszerek mellékhatásaként is jelentkezhetnek (5. ábra) (11). Az irodalomban pimecrolimus, tacrolimus, tirozin-kináz gátlók, tumor necrosis factor-alfa gátlók, ribavirin, phosphodiesterase-5 gátlók, nikotinsav, magas dó-zisú B6 és B12 vitamin, valamint interferon-alfa adását követően találha-tunk erre vonatkozólag eset ismer te té -seket.…”