Tacrolimus for Primary Liver Transplantation: 12 to 15 Years Actual Follow-Up With Safety Profile

Long-term Probability of and Mortality From De Novo Malignancy After Liver Transplantation

“…De novo malignancy occurs more commonly after liver transplantation than in the general population 1, 2. Despite the fact that many of the malignancies described are skin cancers with an excellent prognosis, the overall mortality rate from de novo malignancy in this patient population is high 1, 3–5.…”

Osteosarcoma of the jaw in children and young adults

“…Several complications post‐LTx have been described,5 including several different types of neurological,6, 7 cardiovascular,8 respiratory,9–11 and gastrointestinal complications,12 acute and chronic renal failure/impairment13–17; arterial/venous complications,5, 18–20 biliary complications,21, 22 and posttransplant lymphoproliferative disorder/de novo cancers 23–25. Additional complications associated with infections, including bacterial, viral, and fungal infections,26–31 incisional hernias,32 bleeding,33 metabolic disorders,31, 34–38 impaired quality of life,31 and erectile dysfunction39 have also been described. However, the area of numbness below the subcostal incision has not been studied.…”

Beyond five years: Long-term follow-up in pediatric liver transplantation

“…Retransplantation performed due to chronic rejection and secondary biliary cirrhosis was reported to account for a drop in patient and graft survival between 10 and 12 years after transplantation. A recent study from Pittsburgh followed 166 children maintained with tacrolimus immunosuppression for a mean of 13.4 years (11.7-15 years) and reported an 81% patient survival rate, significantly higher than the 54% 12-year actuarial survival reported in tacrolimus-supported adult transplant recipients [7]. Encouraging 10-year survival rates of 66% were reported in children transplanted for hepatoblastoma, based on the United Network for Organ Sharing (UNOS) database (1987)(1988)(1989)(1990)(1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004), and even in 43 children transplanted for hepatocellular carcinoma, with 58% of recipients surviving 10 years [8].…”