Osteosarcoma of the jaw in children and young adults

Huh, Winston W.; Holsinger, F. Christopher; Levy, A.R.; Palla, F.; Anderson, Peter M.

doi:10.1002/hed.21850

Cited by 42 publications

(27 citation statements)

References 57 publications

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“…There are only a few retrospective studies discussing the clinical and diagnostic features and treatment options of JOS due to the rarity of the disease [4,7,8].…”

Section: Discussionmentioning

confidence: 99%

Osteosarcomas of jaw: Experience of a single centre

Argon¹,

Doğanavşargıl²,

Yıldırım³

et al. 2014

Journal of Plastic Surgery and Hand Surgery

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Although osteosarcoma is the most common primary malignant tumour of bone, osteosarcomas of jaw are rare. In osteosarcomas of jaw, evaluating the clinicopathological factors affecting the prognosis is not easy because of different approaches to diagnosis, treatment, and follow-up. This study reviewed 14 cases of JOS that were diagnosed between 1990-2010, in terms of age, gender, site, clinical history, histopathologic type and histopathologic grade, treatment, and prognosis. Median age was 35 years, while male:female ratio was 1.8:1. Eight tumours were located in the mandible. Osteoblastic differentiation was the predominant feature in seven cases followed by chondroid osteosarcoma (four cases), fibroblastic osteosarcoma, low-grade (parosteal) osteosarcoma associated with fibrous dysplasia, and postradiation osteosarcoma (one cases each). During follow-up, recurrence was seen in four patients at least once and they all died. In conclusion, early diagnosis and complete resection seems to be effective in prognosis. Therefore, clinicians and pathologists should be aware of its characteristics and main differential diagnosis to avoid late recognition.

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“…There are only a few retrospective studies discussing the clinical and diagnostic features and treatment options of JOS due to the rarity of the disease [4,7,8].…”

Section: Discussionmentioning

confidence: 99%

Osteosarcomas of jaw: Experience of a single centre

Argon¹,

Doğanavşargıl²,

Yıldırım³

et al. 2014

Journal of Plastic Surgery and Hand Surgery

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“…Thirteen studies that reported specific treatment methods and survival data for individual patients were identified. Table shows the baseline characteristics of these 13 included studies . In total, 205 patients were identified from the articles included, and 21 cases without surgical resection were excluded.…”

Section: Methodsmentioning

confidence: 99%

“…Table 1 shows the baseline characteristics of these 13 included studies. [11][12][13][14][15][16][17][18][19][20][21][22][23] In total, 205 patients were identified from the articles included, and 21 cases without surgical resection were excluded. The total population consisted of 184 patients.…”

Section: Data Extraction and Verificationmentioning

confidence: 99%

An individual patient data meta‐analysis on the effect of chemotherapy on survival in patients with craniofacial osteosarcoma

et al. 2019

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Chemotherapy improves the survival of patients with long bone osteosarcomas. However, the benefits of chemotherapy in the treatment of craniofacial osteosarcoma (CFOS) are still controversial. We searched PubMed and EMBASE from February 1997 to December 2016 to identify studies on CFOS. The individual patient data of these studies were pooled into a meta‐analysis. Univariate and multivariate survival analyses were performed. Thirteen studies with a total of 184 patients met our inclusion criteria. Positive resection margin was a poor prognostic factor for CFOS in the univariate and multivariate survival analyses. Chemotherapy improved overall survival (OS) and disease‐specific survival (DSS) in patients with CFOS who had tumors in the maxilla, positive resection margins, or high‐grade tumors. Patients with local tumor recurrence had better OS and DSS when treated with chemotherapy. Chemotherapy improves survival in patients with CFOS with adverse factors, such as tumors with positive margins, high‐grade tumors, and recurrent tumors.

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“…Most occur in the mandible. In children, they generally show an osteoblastic morphology and tend to be large and of high grade [ 54 ]. In spite of these features, they have a better outcome than extremity osteosarcomas [ 54 ].…”

Section: Sarcomas Of the Oral Cavity/salivary Glandsmentioning

confidence: 97%