Tackling endothelium remodeling in cardiovascular disease

Guľašová, Zuzana; Guerreiro, Susana G.; Link, Rene; Soares, Raquel; Tomečková, Vladimı́ra

doi:10.1002/jcb.29379

Cited by 7 publications

(4 citation statements)

References 54 publications

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“…The next two pathways in Figure 5B (valine, leucine, and isoleucine biosynthesis and valine, leucine and isoleucine degradation) were involved in the metabolism of branched-chain amino acids (BCAA). Zuzana et al considered that dysmetabolism of BCAA may promote VC by influencing endothelial cell remodeling ( 44 ), although there is lack of evidence for this possibility.…”

Section: Discussionmentioning

confidence: 99%

Altered serum metabolome associated with vascular calcification developed from CKD and the critical pathways

Tan

Kang

et al. 2023

Front. Cardiovasc. Med.

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IntroductionVascular calcification (VC) is more likely to be detected in the chronic kidney disease (CKD) population. The mechanism of VC development from CKD is different from that for simple VC and has always been a major research area. The aim of this study was to detect alterations in the metabolome during development of VC in CKD and to identify the critical metabolic pathways and metabolites involved in its pathogenesis.MethodsRats in the model group were given an adenine gavage combined with a high-phosphorus diet to imitate VC in CKD. The aorta calcium content was measured and used to divide the model group into a VC group and non-vascular calcification group (non-VC group). The control group was fed a normal rat diet and given a saline gavage. Ultra-high-performance liquid chromatography-mass spectrometry (UHPLC-MS) was used to determine the altered serum metabolome in the control, VC, and non-VC groups. The identified metabolites were mapped into the Kyoto Encyclopedia of Genes and Genomes (KEGG) database (https://www.genome.jp/kegg/) for pathway and network analyses.ResultThere were 14 metabolites that changed significantly in the VC group, with three metabolic pathways playing critical roles in the pathogenesis of VC in CKD: steroid hormone biosynthesis; valine, leucine and isoleucine biosynthesis; and pantothenate and CoA biosynthesis.ConclusionOur results indicated changes in the expression of steroid sulfatase and estrogen sulfotransferase, and down-regulation of the in situ synthesis of estrogens in the VC group. In conclusion, the serum metabolome alters significantly during the pathogenesis of VC in CKD. The key pathways, metabolites, and enzymes we identified are worth further study and may become a promising therapeutic target for the treatment of VC in CKD.

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Section: Discussionmentioning

confidence: 99%

Altered serum metabolome associated with vascular calcification developed from CKD and the critical pathways

Tan

Kang

et al. 2023

Front. Cardiovasc. Med.

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“…Vascular calcification is a marker of atherosclerosis 21 . In calcified atherosclerotic lesions, VSMCs express a variety of osteogenic differentiation markers 22 , similar to the osteogenic mineralization process 23 . VC is caused by the imbalance of vascular wall mineralization promoters 24 and inhibitors and is a serious health problem with serious clinical consequences 25 .…”

Section: Baseline Characteristics Of the Study Population Are Shown Inmentioning

confidence: 99%

Correlativity between osteocalcin and coronary artery calcification in middle-aged and elderly population

Zhang

2020

Preprint

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Background and Objective: With the increase of aging, osteoporosis and cardiovascular diseases are common diseases in middle-aged and elderly people. The purpose of this study is to explore the correlation between osteocalcin and coronary calcification.Methods: A total of 150 middle-aged and elderly physical examination subjects who had undergone coronary artery CT angiography (CTA) were selected as the research objects. The calcification score of the coronary artery was calculated according to the Agatston (AS) integral method, and the total score was divided into the coronary artery calcification group and the non-calcification group. The indexes of N-terminal midfragment of osteocalcin (N-MID), routine biochemical indexes and basic conditions of each patient were recorded.Results: In the comparison of general data between the non-calcification group and the calcification group, the differences in age(P＜0.001), pressure difference (P = 0.01)and low density lipoprotein cholesterol (LDL-C)(P＜0.001)were statistically significant, the differences in smoking history (P＜0.001)and drinking history (P＜0.001)were statistically significant, and the differences in N-MID (P＜0.001)were statistically significant. Coronary artery calcification score (CACS) was correlated with age, pressure difference, LDL-C, N-MID, smoking history and drinking history. The four variables, age, LDL, N-MID, and smoking history, have certain effects on coronary artery calcification (CAC).Conclusions: In middle-aged and elderly people undergoing physical examination, N-MID is correlated with CAC and can be used as a predictive indicator.

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“…Regular physical activity improves different aspects: vascular endothelium function, glucose tolerance, lipid profile, exercise capacity, stroke volume, and cardiac output. Moreover, regular physical activity normalizes blood pressure, heart rate, regulates peripheral vascular resistance and blood flow distribution [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Expression of the Endothelin-1 Gene and Its Type a Receptor including Physical Activity among Patients with Acute Myocardial Infarction

Dąbek

Piotrkowicz

Głogowska-Ligus

et al. 2022

IJERPH

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Cardiovascular diseases are the most common causes of death, in both Poland and the world. Their development and progression are largely influenced by the lifestyle with the presence/occurrence of classic, modifiable risk factors. Among them, low physical activity plays a significant role. The aim of the study was to evaluate the expression of the endothelin-1 gene and its type A receptor, taking into account physical activity (International Physical Activity Questionnaire—IPAQ) among patients with acute myocardial infarction. A total of 234 patients with acute myocardial infarction were examined, including 167 patients undergoing early post-hospital cardiac rehabilitation and 67 not participating in it. All of them were assessed with the IPAQ questionnaire and the quantitative real-time polymerase reaction method (QRT-PCR). Physical activity in the group of patients after early post-hospital cardiac rehabilitation increased after rehabilitation. Transcriptional activity of the endothelin-1 (ET-1) gene in both studied group of patients increased significantly, but in a group of patients not participating in early post-hospital cardiac rehabilitation more than in a group of patients participating in it. In our study, the expression of ET-1 was also significantly higher in the group of patients with acute myocardial infarction with ST-segment elevation, without diabetes, with lipid disorders, smoking, with normal body weight. Expression of the ENDRA (Endothelin receptor A) gene increased with age. These results prove the beneficial effect of rehabilitation and may indicate another pathomechanism of pro-atherogenic activity of above-mentioned factors.

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Tackling endothelium remodeling in cardiovascular disease

Cited by 7 publications

References 54 publications

Altered serum metabolome associated with vascular calcification developed from CKD and the critical pathways

Altered serum metabolome associated with vascular calcification developed from CKD and the critical pathways

Correlativity between osteocalcin and coronary artery calcification in middle-aged and elderly population

Expression of the Endothelin-1 Gene and Its Type a Receptor including Physical Activity among Patients with Acute Myocardial Infarction

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