Correlativity between osteocalcin and coronary artery calcification in middle-aged and elderly population

Abstract

Background and Objective: With the increase of aging, osteoporosis and cardiovascular diseases are common diseases in middle-aged and elderly people. The purpose of this study is to explore the correlation between osteocalcin and coronary calcification.Methods: A total of 150 middle-aged and elderly physical examination subjects who had undergone coronary artery CT angiography (CTA) were selected as the research objects. The calcification score of the coronary artery was calculated according to the Agatston (AS) integral method, and the total score was divided into the coronary artery calcification group and the non-calcification group. The indexes of N-terminal midfragment of osteocalcin (N-MID), routine biochemical indexes and basic conditions of each patient were recorded.Results: In the comparison of general data between the non-calcification group and the calcification group, the differences in age(P＜0.001), pressure difference (P = 0.01)and low density lipoprotein cholesterol (LDL-C)(P＜0.001)were statistically significant, the differences in smoking history (P＜0.001)and drinking history (P＜0.001)were statistically significant, and the differences in N-MID (P＜0.001)were statistically significant. Coronary artery calcification score (CACS) was correlated with age, pressure difference, LDL-C, N-MID, smoking history and drinking history. The four variables, age, LDL, N-MID, and smoking history, have certain effects on coronary artery calcification (CAC).Conclusions: In middle-aged and elderly people undergoing physical examination, N-MID is correlated with CAC and can be used as a predictive indicator.

The Study on the Problems of Digitally Disadvantaged Groups in Using Online Medical Registration Public Numbers--Take Changsha Xiangya Hospital as an Example

“…protection measures to eliminate the concerns of digitally disadvantaged groups. Specific solutions include: adding a key to get the cell phone number plug-in for WeChat public number reservation to save the operation time of registration; adding 26-letter side sorting for department selection to make it easier to find; solving the public number searching problem; turning the search magnifying glass into dynamic to increase the visual effect; optimizing the public number interface design and aesthetics; switching the pop-up window button position; providing voice help or font enlargement adjustment within the online program; adding AI navigation, online consultation to check the general condition and departmental recommendations; additional human customer service to strengthen the doctorpatient contact, and increase the online consultation function to facilitate users [6].…”

Flexible sensing-based knee joint flexion monitoring system

“…Knee osteoarthritis (KOA) is chronic arthritis characterized by degenerative lesions of knee cartilage and secondary osteophytes, and is one of the most common joint diseases, mainly manifested as knee pain and inability to bend the knee. According to the World Health Organization, there are approximately 355 million patients with osteoarthritis around the world, and the incidence increases with age, ranging from 10% to 17% in people aged 40 years, 50% in people aged 60 years, and up to 80% in people aged 75 years or older [1] . The number of patients with KOA in China has reached 133 million, accounting for 25.76% of the global incidence of osteoarthritis [2] .…”