Tacaribe Virus, a New Agent Isolated from Artibeus Bats and Mosquitoes in Trinidad, West Indies *

Downs, W. G.; Anderson, Charles R.; Spence, L.; Aitken, T. H. G.; Greenhall, A H

doi:10.4269/ajtmh.1963.12.640

Cited by 149 publications

(101 citation statements)

References 0 publications

Supporting

Mentioning

100

Contrasting

Order By: Relevance

“…Taken together, these data show that TCRV-induced apoptotic signalling can be observed in a variety of different mammalian cell types and does not seem to be dependent on the IFN competence of the cells. Based on recent findings, which suggest that the natural reservoir hosts of TCRV are ticks and bats (Downs et al, 1963;Sayler et al, 2014), it is necessary to extend the present analyses of primate cells to cells from the natural hosts. This will give valuable insights into how the host switch of TCRV changed the response of the infected cell in view of regulation of apoptosis.…”

Section: Discussionmentioning

confidence: 99%

The New World arenavirus Tacaribe virus induces caspase-dependent apoptosis in infected cells

Wolff

Groseth

Meyer

et al. 2016

Journal of General Virology

View full text Add to dashboard Cite

The Arenaviridae is a diverse and growing family of viruses that already includes more than 25 distinct species. While some of these viruses have a significant impact on public health, others appear to be non-pathogenic. At present little is known about the host cell responses to infection with different arenaviruses, particularly those found in the New World; however, apoptosis is known to play an important role in controlling infection of many viruses. Here we show that infection with Tacaribe virus (TCRV), which is widely considered the prototype for non-pathogenic arenaviruses, leads to stronger induction of apoptosis than does infection with its human-pathogenic relative Junín virus. TCRV-induced apoptosis occurred in several cell types during late stages of infection and was shown to be caspase-dependent, involving the activation of caspases 3, 7, 8 and 9. Further, UV-inactivated TCRV did not induce apoptosis, indicating that the activation of this process is dependent on active viral replication/transcription. Interestingly, when apoptosis was inhibited, growth of TCRV was not enhanced, indicating that apoptosis does not have a direct negative effect on TCRV infection in vitro. Taken together, our data identify and characterize an important virus-host cell interaction of the prototypic, non-pathogenic arenavirus TCRV, which provides important insight into the growing field of arenavirus research aimed at better understanding the diversity in responses to different arenavirus infections and their functional consequences.

show abstract

Section: Discussionmentioning

confidence: 99%

The New World arenavirus Tacaribe virus induces caspase-dependent apoptosis in infected cells

Wolff

Groseth

Meyer

et al. 2016

Journal of General Virology

View full text Add to dashboard Cite

show abstract

“…Nevertheless, the study of Cogswell-Hawkinson et al (2012) does not support the hypothesis that A. jamaicensis is a natural reservoir host for TCRV, because the injection of high doses resulted in significant and fatal disease including pneumonia, pathological changes in liver and spleen and brain lesions. One study (Downs et al 1963) however revealed close correspondence between a strain isolated from a mosquito pool and one isolated from a bat. Unfortunately, the pool consisted of 18 mosquito species, so that no precise information about the possible vector can be given.…”

Section: Flaviviridae: Flavivirusmentioning

confidence: 99%

“…Diseases caused by the Tacaribe virus complex of the new world are Argentine haemorrhagic fever, Brazilian haemorrhagic fever, Venezuelan haemorrhagic fever and another yet unnamed haemorrhagic fever, induced by Junín, Sabiá, Guanarito, Machupo and Chapare viruses (Carballal et al 1987;Cogswell-Hawkinson et al 2012;Tesh et al 1994). In contrast to the other arenaviruses, which have all been isolated from rodents, Tacaribe virus was originally isolated from two bat species: great fruit-eating bats (Artibeus lituratus) and Jamaican fruit bats (A. jamaicensis) (Downs et al 1963;Price 1978). Furthermore, Price (1978) was able to detect antibodies against TCRV in the little yellow-shouldered bat (Sturnira lilium), Heller's broad-nosed bat (Platyrrhinus helleri) and in the vampire bat (Desmodus rotundus).…”

Section: Flaviviridae: Flavivirusmentioning

confidence: 99%

Bats as Potential Reservoir Hosts for Vector-Borne Diseases

Melaun

Werblow

Busch

et al. 2013

Bats (Chiroptera) as Vectors of Diseases and Parasites

View full text Add to dashboard Cite

show abstract

“…Around the same time, Rivers and McNair Scott demonstrated that LCMV is the cause of an aseptic meningitis in humans that today is called lymphocytic choriomeningitis [93,114,115]. In 1956, a novel agent later called Tacaribe virus (TCRV) was isolated from Jamaican fruit-eating bats (Artibeus jamaicensis trinitatis) in Trinidad and Tobago, but the virus was not associated with overt human disease [52] (anecdotal reports suggest a single human infection that resulted in a mild febrile illness). In 1959, Junín virus (JUNV), maintained in nature by drylands lauchas (Calomys musculinus), was identified as the cause of Junín/Argentinian hemorrhagic fever [105,106].…”

Section: Past Developments In Arenavirus Taxonomymentioning

confidence: 99%

Past, present, and future of arenavirus taxonomy

et al. 2015

View full text Add to dashboard Cite

Until recently, members of the monogeneric family Arenaviridae (arenaviruses) have been known to infect only muroid rodents and, in one case, possibly phyllostomid bats. The paradigm of arenaviruses exclusively infecting small mammals shifted dramatically when several groups independently published the detection and isolation of a divergent group of arenaviruses in captive alethinophidian snakes. Preliminary phylogenetic analyses suggest that these reptilian arenaviruses constitute a sister clade to mammalian arenaviruses. Here, the members of the International Committee on Taxonomy of Viruses (ICTV) Arenaviridae Study Group, together with other experts, outline the taxonomic reorganization of the family Arenaviridae to accommodate reptilian arenaviruses and other recently discovered mammalian arenaviruses and to improve compliance with the Rules of the International Code of Virus Classification and Nomenclature (ICVCN). PAirwise Sequence Comparison (PASC) of arenavirus genomes and NP amino acid pairwise distances support the modification of the present classification. As a result, the current genus Arenavirus is replaced by two genera, Mammarenavirus and Reptarenavirus, which are established to accommodate mammalian and reptilian arenaviruses, respectively, in the same family. The current species landscape among mammalian arenaviruses is upheld, with two new species added for Lunk and Merino Walk viruses and minor corrections to the spelling of some names. The published snake arenaviruses are distributed among three new separate reptarenavirus species. Finally, a non-Latinized binomial species name scheme is adopted for all arenavirus species. In addition, the current virus abbreviations have been evaluated, and some changes are 123Arch Virol (2015) 160:1851-1874 DOI 10.1007/s00705-015-2418 introduced to unequivocally identify each virus in electronic databases, manuscripts, and oral proceedings.

show abstract

Tacaribe Virus, a New Agent Isolated from Artibeus Bats and Mosquitoes in Trinidad, West Indies *

Cited by 149 publications

References 0 publications

The New World arenavirus Tacaribe virus induces caspase-dependent apoptosis in infected cells

The New World arenavirus Tacaribe virus induces caspase-dependent apoptosis in infected cells

Bats as Potential Reservoir Hosts for Vector-Borne Diseases

Past, present, and future of arenavirus taxonomy

Contact Info

Product

Resources

About