Tabardillo, An American Variety of Typhus

Mooser, H.

doi:10.1093/infdis/44.3.186

Cited by 27 publications

(8 citation statements)

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“…The American sera, however, do not contain any group agglutinins for X 2, and a similar result has been published recently by Spencer and Maxcy (1930). Should this finding be confirmed by investigations on a larger scale, another peculiarity of the virus of endemic typhus of the United States would thus have been established, in addition to the property of producing conspicuous scrotal and testicular lesions in infected animals, which this virus (Maxcy, 1929 a, b, c;Pinkerton, 1929) shares with those of the Mexican Tabardillo " (Neill, 1917;Mooser, 1928Mooser, , 1929 and of Rocky Mountain spotted fever.…”

Section: Sera Fromsupporting

confidence: 64%

Serological Varieties of Typhus Fever

Félix

Rhodes

1931

J. Hyg.

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1. Fletcher and Lesslar's observations on two serological types of tropical typhus have been fully confirmed.2. The antigenic relationship between the indologenicB. proteusX 19 and the non-indologenic Kingsbury strain is of the same order as that obtaining between the X 19 and X 2 types ofB. proteusX.3. The Kingsbury strain is an antigenic variant derived from the original X 19 culture and represents another serological type ofB. proteusX. The symbol XK is suggested for this type.4. Sera from cases of classical European typhus and of endemic typhus of the United States of America and of Australia have been tested for the occurrence of main and group O agglutinins for the known types ofB. proteusX.5. H agglutination as source of error in the diagnosis of typhus cases is illustrated by some examples.6. Sera from cases of tsutsugamushi from Sumatra and Japan react with type XK like the Malayan cases of this disease described by Fletcher and co-workers.7. This latter reaction is of the order of group O agglutination. It is suggested that antigenically the virus of tsutsugamushi corresponds to another serological type ofB. proteusX which is yet unknown.8. The data published on the serum reactions in Rocky Mountain spotted fever and in the “fièvre exanthématique” of Marseilles are analysed. It is suggested that these two diseases represent further serological varieties of typhus.9. The significance hitherto attached to negative agglutination tests withB. proteusX and to negative cross-immunity tests obtained with some typhuslike diseases requires revision in the light of recent observations.

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Section: Sera Fromsupporting

confidence: 64%

Serological Varieties of Typhus Fever

Félix

Rhodes

1931

J. Hyg.

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“…The comparison with herpes is especially important since, in both herpes and typhus, brain material was used under identical conditions, It would seem from these experiments that the agent of typhus did not, in regard to filtration, fall into the class of the so-caUed "filterable" agents. Its occasional passage through filters which held back bacteria in our own work as in the isolated experiments of NicoUe and his associates, can be taken to indicate that the typhus agent, while larger than the filterable viruses, yet was smaller than a typical small bacterium--a supposition which would be consistent with the observed size of the Mooser bodies (7) (Rickettsia prowazeki seen in the tunica of guinea pigs). Moreover, cultural studies on all the filtrates carried over periods of from 2 to 3 weeks after filtration would indicate that the typhus virus was not bacterial and had no relationship to the occasionally observed diphtheroid organisms that can be cultivated, from time to time, from typhus tunicas.…”

Section: The Filtration Of Typhus Virusmentioning

confidence: 56%

Studies on Mexican Typhus Fever. I

Zinsser

Batchelder

1930

Journal of Experimental Medicine

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The following notes on experiments with the virus of typhus fever are presented in the briefest possible manner, since to a considerable extent they represent confirmations of previous work. Our results are published because, in a subject as difficult as this one, confirmation of important facts that have been observed a few times only and have in some cases been questioned, constitutes a necessary criterion for the planning of further investigation.

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“…Thus, the guinea pig is a long-standing host for experimental studies of typhus. One of the results of these early studies was the differentiation of the agent of epidemic typhus fever, Rickettsia prowazeki, from the agent of murine (endemic) typhus fever, Rickettsia mooseri (Rickettsia taphi) (16). Because R. mooseri produces a more severe disease in guinea pigs than R. prowazeki (36) (the converse of their relative virulence for humans), R. mooseri infection in this laboratory animal is often studied as a model of typhus infections.…”

mentioning

confidence: 99%

Mechanisms of immunity in typhus infection: some characteristics of Rickettsia mooseri infection of guinea pigs

1978

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Rickettsia mooseri infection has been studied in syngeneic guinea pigs inoculated intradermally with the objective of developing a model for the study of immune mechanisms. Characterization of infection included the following: a study of replication, dissemination, and clearance of rickettsiae; measurement of the antibody response with different rickettsial antigens and tests; and attempts to measure the cell-mediated immune response using the correlate of delayed-type hypersensitivity skin reactions. Following intradermal inoculation, rickettsiae replicate locally and then spread to the draining lymph nodes and subsequently cause systemic infection. Spread to draining lymph nodes occurred before the appearance of circulating antibody, whereas systemic infection occurred afterwards. Two distinct patterns of acquired resistance developed. The first was marked by a cessation of rickettsial growth within a given organ and the second by a clearance of rickettsiae. The duration of each of these phases differed markedly from one organ to another. Delayed-type hypersensitivity was not demonstrated by skin testing.

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Tabardillo, An American Variety of Typhus

Cited by 27 publications

References 0 publications

Serological Varieties of Typhus Fever

Serological Varieties of Typhus Fever

Studies on Mexican Typhus Fever. I

Mechanisms of immunity in typhus infection: some characteristics of Rickettsia mooseri infection of guinea pigs

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