Studies on Mexican Typhus Fever. I

Zinsser, Hans; Batchelder, A. P.

doi:10.1084/jem.51.6.847

Cited by 15 publications

(6 citation statements)

References 5 publications

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“…1. This, we believe, accounts for the occasional slight infectiousness of washed leucocytes recorded in a previous paper (7). It also suggested to us that possibly the destruction of Rickettsiae in the body was actively carried on by the mobile phagocytes, and that an inhibition of phagocytosis might give us better results.…”

supporting

confidence: 61%

Studies on Typhus Fever

Zinsser

1930

Journal of Experimental Medicine

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supporting

confidence: 61%

Studies on Typhus Fever

Zinsser

1930

Journal of Experimental Medicine

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“…Our attention was turned to serovaccination by an incidental observation made by one of us, with Batchelder, in 1930 (9). At that time, a guinea pig which had been used for neutralization tests of conva-lescent guinea pig serum against homologous (routine) virus and found fully protected, was reinoculated several weeks later, and failed to exhibit any symptoms of typhus.…”

Section: Serovaccinationmentioning

confidence: 99%

Further Studies on Typhus Fever

Zinsser

Macchiavello

1936

Journal of Experimental Medicine

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It appears justified to conclude from the studies of Weigl (1), and from our own work with Castaneda, that active immunization against typhus fever with killed Rickettsiae can be achieved, provided a sufficient accumulation of the organisms can be obtained for vaccine preparation. Such mass production of Rickettsiae is also an indispensable preliminary for the immunization of horses, donkeys, or goats in the preparation of sera for temporary prop.hyla~ds and for therapeutic application in man. 1 With the routine strains of typhus, as we have reported in preceding papers (2), such Rickettsia accumulation has been achieved by a number of methods, all of which depend upon the intraperitoneal infection of rats in which resistance had been reduced by a variety of methods. All such attempts, even the use of preliminary X-ray radiation of the animals (the most satisfactory of the methods employed), have completely failed when the European virus is used. Indeed, our persistent failures in this regard are one of the most convincing reasons for our belief, elsewhere set forth, that the agents of the routine and European infections--so closely related in many of their attributes--are nevertheless distinct and biologically fixed varieties, not permanently convertible one into the * Guggenheim Fellow.In this respect, the situation appears to be not unlike that revealed by recent investigations for virus immunization--namely, that for the production of any degree of immunity with killed virus, large quantities of the material are required. It is not impossible that this point of similarity between infectious agents otherwise so far apart in biological attributes may be related to the tendency for intracellular localization which characterizes the pathogenic behavior of both.

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“…Various attempts had previously been made by other workers (Kuczynski (2), Krontowski and Hach (3), Wolbach and Schlesinger (4), Rix (5), Zinsser and Batchelder (6) (cf. Zinsser and Castaneda (7))), to cultivate typhus fever rickettsiae.…”

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confidence: 99%