T2∗ MRI changes in the heart and liver of ex-thalassemic patients after hematopoietic stem cell transplantation

Hamidieh, Amir Ali; Tayebi, Sirous; Shamshiri, Ahmad Reza; Behfar, Maryam; Ghavamzadeh, Ardeshir

doi:10.1016/j.hemonc.2014.06.002

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…However, the hepatic T2* value was decreased, and hepatic iron deposition was aggravated. This finding is consistent with that reported by Amir Ali Hamideh et al, who showed cardiac and hepatic iron deposition changes after HSCT in thalassemia patients ( 32 ). After HSCT, thalassemia patients obtain effective erythropoiesis.…”

Section: Discussionsupporting

confidence: 93%

Relationship between Iron deposition and T lymphocytes in children with β-thalassemia with haematopoietic stem cell transplantation

Zhou

Luo²

2022

Front. Pediatr.

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Backgroundβ-Thalassemia cellular immunity is associated with iron overload. However, the relationship between varying degrees of iron deposition and T cell immune recovery after allogeneic haematopoietic stem cell transplantation(allo-HSCT) in children remain unclear.MethodsA retrospective analysis was performed on 84 children with β-Thalassemia undergoing sibling allo-HSCT. According to the degrees of hepatic iron deposition, patients were divided into four classes. T lymphocyte counts were measured. Hepatic iron deposition was assessed by T2* MRI. Epstein–Barr virus and cytomegalovirus infection rates and graft-vs.-host disease incidence were recorded.ResultsImmune recovery after allo-HSCT was compared between the two groups. Normal vs. mild group: CD4 cells were higher at 1, 3, and 6 months (P < 0.05), CD3 and CD8 cells were higher at 3 and 6 months, and 1 year in normal group (P < 0.05). Normal vs. moderate group: CD3 and CD4 cells were higher at 1, 3 and 6 months, and 1 year (P < 0.05), CD8 cells were higher at 1 and 3 months, and 1 year in normal group (P < 0.05). Normal vs. severe group: CD3, CD4 and CD8 cell at 1, 3 and 6 months, and 1 year in normal group (P < 0.05). Mild vs. moderate group: CD3, CD4 and CD8 cells were higher at 1 month in mild group (P < 0.05). Mild vs. severe group: CD4 cells were higher at 1, 3 and 6 month, and 1 year (P < 0.05), CD3 and CD8 cells were higher at 1 month in mild group (P < 0.05). Moderate vs. severe group: CD4 cells were higher at 3 months (P < 0.05), CD8 cells were higher at 6 months in moderate group (P < 0.05). The hepatic T2* values were positively correlated with CD3, CD4 and CD8 cells. The infection rates of Epstein-Barr virus and cytomegalovirus were significantly different among the groups (P < 0.05).ConclusionIron deposition affects immune recovery of T lymphocytes after allo-HSCT in children with β-thalassemia. The lower the levels of iron deposition, the greater the CD4 cell count.

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Section: Discussionsupporting

confidence: 93%

Relationship between Iron deposition and T lymphocytes in children with β-thalassemia with haematopoietic stem cell transplantation

Zhou

Luo²

2022

Front. Pediatr.

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“…Hepatic and myocardial T2* values before and 6 months after HCT were measured and analyzed. Results showed that there was not a statistically significant increase in myocardial T2* values after HCT, instead Hepatic T2* values significantly decreased after HCT showing an increase of the liver iron 35…”

Section: Free Iron Toxicity During the Early Transplant Phase (Beforementioning

confidence: 77%

Guest Editor: Raffaella Origa IRON TOXICITY AND HEMOPOIETIC CELL TRANSPLANTATION: TIME TO CHANGE THE PARADIGM.

Pilo¹,

Angelucci

2019

Mediterr J Hematol Infect Dis

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The issue of iron overload in hemopoietic cell transplantation has been first discussed in the field of transplantation for thalassemia. Thalassemia major is characterized by ineffective erythropoiesis and hemolysis leading to anemia in the majority of patients. Patients require regular blood transfusion therefore they develop iron overload causing organ damage and hematopoietic cell transplantation (HCT) is a consolidated reliably curative option. In this category of patients an important issue for transplant outcome is the iron burden before transplant and in the long-life post-transplant. Nevertheless, today the concept of the impact of iron overload / toxicity on the outcome of HCT) has been extended to other diseases characterized by periods of variable duration of transfusion dependence Recent preclinical data has shown how increased production of reactive oxygen species (ROS) resulting under iron overload condition, could impair the stem cells clonality capacity, proliferation and maturation. Also, microenvironment cells could be affected through this mechanism. For this reason, iron overload is becoming an important issue also in the engraftment period post-transplantThe aim of this review is to update consolidated knowledge about the role of iron overload/iron toxicity in the HCT setting in non-malignant and in malignant diseases introducing the concept of exposition of free toxic iron forms and related cellular damage in the different stage of transplant.

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“…Iron overload post HSCT has been associated with mainly long term complications including endocrinopathies, cardiac and liver dysfunction [43, 79,80]. The timing and method of iron overload assessment however is not defined in pediatrics post HSCT and centers develop their own strategies to detect and then treat.…”

Section: What Is the Optimal Treatment Approach For Transfusional Hemmentioning

confidence: 99%

Complex Transfusion Issues in Pediatric Hematopoietic Stem Cell Transplantation

Webb

Abraham

2016

Transfusion Medicine Reviews

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T2∗ MRI changes in the heart and liver of ex-thalassemic patients after hematopoietic stem cell transplantation

Cited by 5 publications

References 25 publications

Relationship between Iron deposition and T lymphocytes in children with β-thalassemia with haematopoietic stem cell transplantation

Relationship between Iron deposition and T lymphocytes in children with β-thalassemia with haematopoietic stem cell transplantation

Guest Editor: Raffaella Origa IRON TOXICITY AND HEMOPOIETIC CELL TRANSPLANTATION: TIME TO CHANGE THE PARADIGM.

Complex Transfusion Issues in Pediatric Hematopoietic Stem Cell Transplantation

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