T1-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis

Bhavesh, Riju; Lechuga‐Vieco, Ana Victoria; Ruíz-Cabello, Jesús; Herranz, Fernando

doi:10.3390/nano5041880

Cited by 20 publications

(23 citation statements)

References 22 publications

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“…The reaction is conducted at 100 • C for 10 min in the presence of hydrazine hydrate (reducing agent) and a surfactant, usually dextran or sodium citrate. In a first approach, a r 1 = 5.97 mM −1 s −1 at 1.5 T was obtained using (FITC)-dextran or dextran 6KDa as surfactant [108,109]. After these first approaches, better longitudinal relaxivities were observed using sodium citrate as surfactant.…”

Section: Microwave Assisted Synthesismentioning

confidence: 99%

“…In 2015, Bhavesh et al [108] proposed an extremely fast microwave synthesis of fluorescein-labelled dextran-coated extremely small IONPs for their use as a contrast agent for T 1 -weighted MRI. This method yielded very small NPs with hydrodynamic diameters of 21.5 nm and with a r 2 /r 1 ratio of 4.7 suitable for T 1 -MRI.…”

Section: Iron-based and Iron Oxide Nanoparticlesmentioning

confidence: 99%

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Iron Oxide Nanoparticles: An Alternative for Positive Contrast in Magnetic Resonance Imaging

et al. 2020

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Iron oxide nanoparticles have been extensively utilised as negative (T2) contrast agents in magnetic resonance imaging. In the past few years, researchers have also exploited their application as positive (T1) contrast agents to overcome the limitation of traditional Gd3+ contrast agents. To provide T1 contrast, these particles must present certain physicochemical properties with control over the size, morphology and surface of the particles. In this review, we summarise the reported T1 iron oxide nanoparticles and critically revise their properties, synthetic protocols and application, not only in MRI but also in multimodal imaging. In addition, we briefly summarise the most important nanoparticulate Gd and Mn agents to evaluate whether T1 iron oxide nanoparticles can reach Gd/Mn contrast capabilities.

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Section: Microwave Assisted Synthesismentioning

confidence: 99%

Section: Iron-based and Iron Oxide Nanoparticlesmentioning

confidence: 99%

Iron Oxide Nanoparticles: An Alternative for Positive Contrast in Magnetic Resonance Imaging

et al. 2020

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“…In these cases, the large negative contrast promoted by superparamagnetic iron oxide is not the best option. Because of that, in the last years there has been an intense development of extremely small (2-3 nm core size), superparamagnetic, IONPs as T 1 contrast agents [42,43]. In this case, the effect observed here is the shortening of longitudinal relaxation time (T 1 ).…”

Section: Iron Oxide Nanoparticles For Imagingmentioning

confidence: 95%

“…This T 1 -based (bright or positive) contrast is usually of more practical use for physicians when compared with its T 2 counterpart. In one of our works, we illustrated this possibility using a microwave assisted onepot synthesis of extremely small, FITC-CM dextran (4 kDa) capped iron oxide nanoparticles (fdIONP) for T 1 -based MRI contrast [42]. The particles were biocompatible, showed a long circulatory half-life and multimodal imaging ability due to the presence of FITC, especially for histological validation (figure 3) [11].…”

Section: Iron Oxide Nanoparticles For Imagingmentioning

confidence: 99%

Recent advances in the preparation and application of multifunctional iron oxide and liposome-based nanosystems for multimodal diagnosis and therapy

et al. 2016

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Nowadays, thanks to the successful discoveries in the biomedical field achieved in the last two decades, a deeper understanding about the complexity of mechanistic aspects of different pathological processes has been obtained. As a consequence, even the standard therapeutic protocols have undergone a vast redesign. In fact, the awareness about the necessity to progress towards a combined multitherapy in order to potentially increase the final healing chances has become a reality. One of the crucial elements of this novel approach is that large amounts of detailed information are highly needed and in vivo imaging techniques represent one of the most powerful tools to visualize and monitor the pathological state of the patient. To this scope, due to their unique features, nanostructured materials have emerged as attractive elements for the development of multifunctional tools for diagnosis and therapy. Hence, in this review, the most recent and relevant advances achieved by applying multifunctional nanostructures in multimodal theranosis of different diseases will be discussed. In more detail, the preparation and application of single multifunctional nano-radiotracers based on iron oxides and enabling PET/MRI dual imaging will be firstly detailed. After that, especially considering their highly promising clinical potential, the preparation and application of multifunctional liposomes useful for multimodal imaging and therapy will be reviewed. In both cases, a special focus will be set on the application of such a multifunctional nanocarriers in cancer as well as cardiovascular diseases.

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“…This method [154] In a recent study, FITC-dextran coated iron oxide nanoparticles were synthesized by the hydrazine mediated reduction of iron (III) chloride salts in the presence of dextran under continuous stirring and microwave irradiation. [155] Subsequently, a gel filtration chromatography was used to perform the purification of the sample and removing unreacted iron salts and the excess of hydrazine. MNPs with small size (21.5 nm) and an excellent reproducibility were synthesized.…”

Section: Microwave Assisted Synthesismentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

193

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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T1-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis

Cited by 20 publications

References 22 publications

Iron Oxide Nanoparticles: An Alternative for Positive Contrast in Magnetic Resonance Imaging

Iron Oxide Nanoparticles: An Alternative for Positive Contrast in Magnetic Resonance Imaging

Recent advances in the preparation and application of multifunctional iron oxide and liposome-based nanosystems for multimodal diagnosis and therapy

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

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